Effects of Oil and Drug Concentrations on Droplets Size of Palm Oil Esters (POEs) Nanoemulsion

Sakeena, M. H. F.; Elrashid, S. M.; Munavvar, A. S.; Azmin, M. N.

doi:10.5650/jos.60.155

Cited by 40 publications

(22 citation statements)

References 15 publications

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“…Additionally, alcohol molecules may enter the inner phase, which causes the expansion of the interfacial film, leading to size increase and instability (39). Our findings also showed that going from low to high values of oil decreases the TR, most probably as a result of size increasing of the hydrophobic core and the whole particle (40,41). It can be argued that loading more oil molecules into the nanoemulsion particles makes them more polydispersed which pushes the system towards Oswald ripening (42).…”

Section: Discussionsupporting

confidence: 63%

Investigating the Parameters Affecting the Stability of Superparamagnetic Iron Oxide-Loaded Nanoemulsion Using Artificial Neural Networks

et al. 2012

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Abstract. Nanoemulsions are increasingly being investigated for their fascinating capability of loading both hydrophobic and hydrophilic molecules while their stability is still an issue, being affected by various factors. In this study, to evaluate the dominant factors affecting the stability of nanoemulsions, artificial neural networks (ANNs) were implemented. Nanoemulsions of almond oil in water containing oleic acidcoated superparamagnetic iron oxide nanoparticles were prepared using a mixture of Tween 80 and Span 80 as surfactant system and ethanol as a co-surfactant. The ratio of transparency of the samples at 30 min and 7 days after preparation was taken as an indication of the stability of samples. Four independent variables, namely, concentration of nanoparticle, surfactant, oil, and alcohol were investigated to find their relations with the dependent variable (i.e., transparency ratio). Using ANNs modeling, it was concluded that the stability is affected by all variables, with all variables showing reverse effect on the stability beyond an optimum amount.

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Section: Discussionsupporting

confidence: 63%

Investigating the Parameters Affecting the Stability of Superparamagnetic Iron Oxide-Loaded Nanoemulsion Using Artificial Neural Networks

et al. 2012

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“…Recently, some studies have suggested that an inflammatory microenvironment may facilitate carcinogenesis and tumor angiogenesis, furthermore, scientific literature describes a higher expression of cyclooxygenase (COX) in tumor tissues [3] which leads to the hypothesis that the use of NSAIDs may contribute to control tumor progression, thus, increasing the efficacy of cancer therapy. Ketoprofen (KP) is a potent inhibitor of the COX enzyme, the main source of prostaglandins, one of the mediators of the inflammatory process [4,5]. This drug was also reported as an inhibitor of cell growth in in vitro and in vivo models of glioma tumors [6].…”

Section: Introductionmentioning

confidence: 99%

Ketoprofen-loaded pomegranate seed oil nanoemulsion stabilized by pullulan: Selective antiglioma formulation for intravenous administration

Ferreira

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Gehrcke

et al. 2015

Colloids and Surfaces B: Biointerfaces

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“…The 2D simplex contour (Figure 2(b)) and 3D (Figure 2(c)) plots also confirm the significant effects of LO (%) (Factor A) and Lauroglycol-FCC (%) (Factor C) on globule size. The interaction effects displayed in these plots show that minimum values for globule size were observed at low values of Factor A, intermediate values of Factor B, and high values of Factor C. It has been established that higher oil content leads to larger globule size, and hence, the present observation regarding Factor A is acceptable (Sakeena et al, 2011). In addition, co-surfactants have been reported to reduce the interfacial tension of globules to values below that produced by a surfactant alone (Gurram et al, 2015).…”

Section: Globule Sizementioning

confidence: 66%

Oral gel loaded with penciclovir–lavender oil nanoemulsion to enhance bioavailability and alleviate pain associated with herpes labialis

et al. 2021

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Herpes labialis, caused by herpes simplex virus type 1, is usually characterized by painful skin or mucosal lesions. Penciclovir (PV) tablets are found to be effective against herpes labialis but suffer from poor oral bioavailability. This study aimed to combine the benefits of PV and lavender oil (LO), which exhibits anesthetic activity, in the form of a self-nanoemulsifying drug delivery system (SNEDDS) for the treatment of herpes labialis. Toward this purpose, LO (oil), Labrasol:Labrafil M1944 CS in the ratio of 6:4 (surfactant mixture), and Lauroglycol-FCC (co-surfactant, selected based on the solubility of PV) were evaluated as the independent factors using a distance quadratic mixture design. The formulation was optimized for the minimum globule size and maximum stability index and was determined to contain 14% LO, 40.5% Labrasol:Labrafil 1944 (6:4), and 45.5% Lauroglycol-FCC. The optimized PV-LO-SNEDDS was embedded in chitosan hydrogel and the resulting formulations coded by (O3) were prepared and evaluated. The rheological studies demonstrated a combined pseudoplastic and thixotropic behavior with the highest flux of PV permeation across sheep buccal mucosa. Compared to a marketed 1% PV cream, the O3 formulation exhibited a significantly higher and sustained PV release, nearly twice the PV permeability, and a relative bioavailability of 180%. Overall, results confirm that the O3 formulation can provide an efficient delivery system for PV to reach oral mucosa and subsequent prolonged PV release. Thus, the PV-LO-SNEDDS embedded oral gel is promising and can be further evaluated in clinical settings to establish its therapeutic use in herpes labialis.

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Effects of Oil and Drug Concentrations on Droplets Size of Palm Oil Esters (POEs) Nanoemulsion

Cited by 40 publications

References 15 publications

Investigating the Parameters Affecting the Stability of Superparamagnetic Iron Oxide-Loaded Nanoemulsion Using Artificial Neural Networks

Investigating the Parameters Affecting the Stability of Superparamagnetic Iron Oxide-Loaded Nanoemulsion Using Artificial Neural Networks

Ketoprofen-loaded pomegranate seed oil nanoemulsion stabilized by pullulan: Selective antiglioma formulation for intravenous administration

Oral gel loaded with penciclovir–lavender oil nanoemulsion to enhance bioavailability and alleviate pain associated with herpes labialis

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