Ogon/Secreted Frizzled functions as a negative feedback regulator of Bmp signaling

Yabe, Taijiro; Shimizu, Takashi; Muraoka, Osamu; Bae, Young-Ki; Hirata, Tsutomu; Nojima, Hideaki; Kawakami, Koichi; Hirano, Toshio; Hibi, Masahiko

doi:10.1242/dev.00506

Cited by 102 publications

(153 citation statements)

References 56 publications

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“…Noggin, follistatin, and chordin, the first neural inducers that were identified (Hemmati-Brivanlou et al 1994;Sasai et al 1994Sasai et al , 1995, act by suppressing BMP signaling (Piccolo et al 1996;Zimmerman et al 1996;Fainsod et al 1997). Additional BMP antagonists secreted from the organizer include Cerberus, Gremlin, Dan, Drm, Coco, and Ogon/Sizzled (sFRP) (Wagner and Mullins 2002;Yabe et al 2003).…”

Section: Neural Inductionmentioning

confidence: 99%

TGF-β Family Signaling in Neural and Neuronal Differentiation, Development, and Function

Meyers

Kessler

2017

Cold Spring Harb Perspect Biol

129

107

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Section: Neural Inductionmentioning

confidence: 99%

TGF-β Family Signaling in Neural and Neuronal Differentiation, Development, and Function

Meyers

Kessler

2017

Cold Spring Harb Perspect Biol

129

107

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“…Sizzled, a secreted frizzled-related protein (sFRP) originally described as a Wnt signaling antagonist, has surprisingly been identified as the product of the ogon/mercedes locus, that acts as an inhibitor of BMP signaling in zebrafish dorsal-ventral patterning (Martyn and SchulteMerker, 2003;Yabe et al, 2003). It has recently been shown that Xenopus and zebrafish Sizzled can act by binding BMP1/TLD-like proteinases and inhibiting their chordinase activity (Lee et al, 2006) (Fig.…”

Section: Inhibitors Of Bmp1/tld-like Proteinasesmentioning

confidence: 99%

The bone morphogenetic protein 1/Tolloid-like metalloproteinases

2007

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A decade ago, bone morphogenetic protein 1 (BMP1) was shown to provide the activity necessary for proteolytic removal of the C-propeptides of procollagens I-III: precursors of the major fibrillar collagens. Subsequent studies have shown BMP1 to be the prototype of a small group of extracellular metalloproteinases that play manifold roles in regulating formation of the extracellular matrix (ECM). Soon after initial cloning of BMP1, genetic studies showed the related Drosophila proteinase Tolloid (TLD) to be necessary for formation of the dorsal-ventral axis in early embryogenesis. It is now clear that the BMP1/TLD-like proteinases, conserved in species ranging from Drosophila to humans, act in dorsal-ventral patterning via activation of transforming growth factor β (TGFβ)-like proteins BMP2, BMP4 (vertebrates) and decapentaplegic (arthropods). More recently, it has become apparent that the BMP1/TLD-like proteinases are key activators of a broader subset of the TGFβ superfamily of proteins, with implications that these proteinases may be key in orchestrating formation of ECM with growth factor activation and BMP signaling in morphogenetic processes.

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“…1B), consistent with the suggestion that wnt8 loss-of-function embryos do not provide a BMP-permissive environment. szl encodes a feedback inhibitor of BMP, thus its expression is a readout of BMP signaling activity (Martyn and Schulte-Merker, 2003;Yabe et al, 2003). szl is expressed in the ventral embryo before and during gastrulation and in the tailbud and ventral posterior epidermis at bud stage (Yabe et al, 2003).…”

Section: Increased Bmp Antagonism Leads To Reduced Bmp Signaling In Wmentioning

confidence: 99%

A direct role for Wnt8 in ventrolateral mesoderm patterning

Baker

Ramel

Lekven

2010

Developmental Dynamics

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Vertebrate dorsoventral patterning requires both Wnt8 and BMP signaling. Because of their multiple interactions, discerning roles attributable specifically to Wnt8 independent of BMP has been a challenge. For example, Wnt8 represses the dorsal organizer that negatively regulates ventral BMP signals, thus Wnt8 loss-of-function phenotypes may reflect the combined effects of reduced Wnt8 and BMP signaling. We have taken a loss-of-function approach in the zebrafish to generate embryos lacking expression of both Wnt8 and the BMP antagonist Chordin. wnt8;chordin loss-of-function embryos show rescued BMP signaling, thereby allowing us to identify Wnt8-specific requirements. Our analysis shows that Wnt8 is uniquely required to repress prechordal plate specification but not notochord, and that Wnt8 signaling is not essential for specification of tailbud progenitors but is required for normal expansion of posterior mesoderm cell populations. Thus, Wnt8 and BMP signaling have independent roles during vertebrate ventrolateral mesoderm development that can be identified through loss-of-function analysis. Developmental Dynamics 239:2828-2836,

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Ogon/Secreted Frizzled functions as a negative feedback regulator of Bmp signaling

Cited by 102 publications

References 56 publications

TGF-β Family Signaling in Neural and Neuronal Differentiation, Development, and Function

TGF-β Family Signaling in Neural and Neuronal Differentiation, Development, and Function

The bone morphogenetic protein 1/Tolloid-like metalloproteinases

A direct role for Wnt8 in ventrolateral mesoderm patterning

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