Introduction:The term e-learning can be described as the usage of electronic devices along with or without the help of internet to conduct a learning environment where it can be beneficial for the student. Nowadays e-learning is being integrated in the tertiary education to provide a better learning environment for the student. The review presents the current practice of e-learning at the tertiary education level in Malaysia. Methodology: A database search of PubMed, Science Direct, and Google scholar was conducted using terms such as e-learning, web-based learning, online learning, virtual learning, mobile learning. Results and Discussion: E-learning is not a new trend of teaching and learning method in the Malaysian education system and already been implemented in some of the universities in Malaysia. In this review, perception of lectures and students on e-learning interventionwere described to understand how well e-learning is being accepted in the education system.Besides that, we also mention the barriersand impact of e-learning implementation on students and the institution itself. Implementation of e-learning in health science andpharmacy education had received mixed responses. More studies on e-learning implementation especially on pharmacy education are needed. Conclusion: By understanding the current e-learning practice in Malaysia universities, it will enable continuous improvement on the e-learning programme so that it can be beneficial to all.