Abstract-The impact of scaling the depth of the shallow trench isolation (STI) region, underneath the gate-to-drain overlap, on the STI drain-extended metal-oxide-semiconductor (DeMOS) mixed-signal performance and hot-carrier behavior is systematically investigated in this work. For the first time, we discuss a dual-STI process for input/output applications. Furthermore, the differences in the hot-carrier behavior of various drain-extended devices are studied under the ON-and OFF-states. We found that the non-STI DeMOS devices are quite prone to failure when compared with the STI DeMOS devices in both the ON-and OFF-states. We introduced a more accurate way of predicting hot-carrier degradation in these types of devices in the ON-state. We show that scaling the depth of the STI underneath the gate is the key for improving both the mixed-signal and hot-carrier reliability performances of these devices.Index Terms-Drain-extended metal-oxide-semiconductor (DeMOS), hot carrier, input/output (I/O), mixed signal, reliability, shallow trench isolation (STI).