Oestrogen‐progestogen Oral Contraceptives and Urinary Calcium Excretion

Goulding, Ailsa; McChesney, Ruth

doi:10.1111/j.1365-2265.1977.tb03328.x

Cited by 18 publications

(6 citation statements)

References 20 publications

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“…Hyperthyroid state was induced by daily sc injections of L-thyroxine (T4, 75 pg/lOOg body wt in 0.3 ml of 0.9% NaC1) for 10 days (25). Similar treatments have been shown to effectively alter thyroid state (24,26). Control and hypothyroid rats received daily sc injections (0.3 ml) of saline.…”

mentioning

confidence: 97%

The Effect of Altered Thyroid State on Prolactin Binding to Liver and 7,12-Dimethylbenz(a)anthracene-Induced Mammary Tumors in Rats

Smith

Hilf

Senior

1978

Experimental Biology and Medicine

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mentioning

confidence: 97%

The Effect of Altered Thyroid State on Prolactin Binding to Liver and 7,12-Dimethylbenz(a)anthracene-Induced Mammary Tumors in Rats

Smith

Hilf

Senior

1978

Experimental Biology and Medicine

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“…In future studies, it may be beneficial to allow a far longer period of acclimatisation to a balanced and adequate diet than was practical in this preliminary experiment. Peripheral blood profiles of pmgesterone and oestradiol follow similar patterns in the cycling mare to those seen in women (Ginther 1979;Prior 1990) where studies have shown that administration of oestrogen andor progestagens, during various stages of the reproductive cycle, can cause alterations in the %FE ratios of Ca and Mg (Goulding and McChesney 1977). Progesterone is generally considered to be a 'sodium-losing' steroid or an 'aldosterone antagonist' (Morimoto et al 1992) and it influences the metabolism of both sodium and potassium in women (Michaelakis et al 1971).…”

Section: Discussionmentioning

confidence: 60%

Influence of the oestrous cycle on electrolyte excretion in the mare

Kinslow

Harris

Gray

et al. 1995

Equine Veterinary Journal

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Summary Equine rhabdomyolysis syndrome (ERS) has been reported to occur more frequently around oestrus. Because electrolyte imbalances have been implicated in pathogenesis, this preliminary study was designed to investigate the possible influence of concentrations of reproductive hormones, progesterone and oestradiol‐17β upon the 24 h%FE values of certain electrolytes. Over a 35 day period, daily plasma progesterone concentrations were measured in 4 mature Thoroughbred mares and serum oestradiol‐17β concentrations in 3 of the mares. At various times during oestrus and dioestrus, 24 h urine collections were carried out and mean 24 h %FE values were determined, in each individual, for sodium (Na), potassium (K), chloride (CI), calcium (Ca), phosphate (PO4) and magnesium (Mg). Although the mares were maintained on a constant dietary intake of electrolytes, group mean %FE values showed cyclical trends which appeared to fluctuate in relation to the stage of the cycle. Large and relatively sudden increases in the volumetric urinary excretion of Na, Ca and Mg (mmol/24 h) were seen in samples collected during the period from 2 days preceding to 4 days following oestrus, compared to the rest of the cycle. Significant correlations were found, in one or more individual animals, between progesterone concentrations and 24 h %FE values for Na, K, Cl, Ca and PO4 and between serum oestradiol‐17β concentrations and Ca, Mg and Cl. This suggests that ovarian steroid hormones may exert an influence on urinary excretion of electrolytes in the mare. Such an influencecould be correlated, in certain individuals, to a significant effect on electrolyte status which, in turn, could potentially result in an increased risk of ERS at particular times of the oestrous cycle.

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“…Several authors have reported use of OCs by women of young adulthood through to perimenopause may have a beneficial effect on bone-mineral density (BMD) [99-102] through reducing short and long term calcium excretion [103][104][105]. However, again this has not been reported by all investigators with some suggesting age at first use [106], physical activity and race [107] might be major factors affecting this relationship.…”

Section: Calciummentioning

confidence: 99%

A Review of the Effects of Oral Contraceptives on Nutrient Status, with Especial Consideration to Folate in UK

Wakeman

2019

JAMMR

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Oral contraceptives (OCs) are widely used by a significant number of women, often commencing at early adolescence. Whilst most research has investigated the physiological effects of OCs, some studies have identified impacts upon nutritional status of certain vitamins and minerals. In this context, a report published by the World Health Organization (WHO) is relevant, since women who take OCs-especially in less well-developed countries might not always have adequate diet. Furthermore, women whose life style is unhealthy, those with malabsorption pathologies, or have genetic polymorphisms that affect vitamin metabolism might also be at risk of the negative impacts on an individual’s nutrient status. This literature review investigates the effects that oral contraceptives might have upon nutrient status. It identifies potential interactions with Vitamins A, B1, B2, B6, B12, C, and E and folic acid as well as magnesium, zinc, selenium, copper, co-enzyme Q10, and beta-carotene status. It then examines the possible consequences that induced depletion of folic acid might cause with especial focus on neural tubes defects in UK, where food supplementation with this vitamin is not yet mandatory. It suggests that in those using this form of contraception or hormone replacement therapy, it is valid to consider appropriate nutritional supplements as a complementary first line strategy in order to prevent possible vitamin and mineral deficiencies.

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Oestrogen‐progestogen Oral Contraceptives and Urinary Calcium Excretion

Cited by 18 publications

References 20 publications

The Effect of Altered Thyroid State on Prolactin Binding to Liver and 7,12-Dimethylbenz(a)anthracene-Induced Mammary Tumors in Rats

The Effect of Altered Thyroid State on Prolactin Binding to Liver and 7,12-Dimethylbenz(a)anthracene-Induced Mammary Tumors in Rats

Influence of the oestrous cycle on electrolyte excretion in the mare

A Review of the Effects of Oral Contraceptives on Nutrient Status, with Especial Consideration to Folate in UK

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