Oestrogen inhibits osteoclast formation induced by periodontal ligament fibroblasts

Abstract

Our data indicate that PLFs may promote osteoclastogenesis more strongly than GFs. 17β-E(2) inhibits the PLF-induced formation of osteoclast-like cells. Thus, the inhibitory effect of oestrogen on osteoclast formation appears to be cell type dependent.

Preliminary investigation on the molecular mechanisms underlying the correlation between VDR‐FokI genotype and periodontitis

“…Because osteoclastogenesis and bone resorption are mainly regulated by bone marrow stromal cells or osteoblasts, and hGFs and hPDLCs both display similarity to osteoblasts, it was believed that both hGFs and hPDLCs were involved in the regulation of periodontal bone metabolism, which was supported by the fact that both the cells could secrete OPG and RANKL in the present study. However, according to the present data, hPDLCs might be more active in inducing osteoclastogenesis than hGFs because hPDLCs synthesized less OPG, which was in line with other researchers’ data . Because the alveolar bone is always in the dynamic balance of bone formation and bone resorption, and hPDLCs are nearer to the alveolar bone than hGFs anatomically, it is reasonable that hPDLCs play a more active role than hGFs in alveolar bone remodeling.…”

Osteogenic differentiation of human ligament fibroblasts induced by conditioned medium of osteoclast-like cells

“…Hypoxia-induced ID-2 may contribute to joint destruction in RA patients by promoting synovial fibroblast-dependent osteoclastogenesis (10). Moreover, oestrogen can inhibit osteoclast formation induced by periodontal ligament fibroblasts (11). The current study suggests that there is interaction between osteoclasts and fibroblasts.…”

Effect of avulsion storage media on periodontal ligament fibroblast differentiation

“…On the other hand, PDL fibroblasts also have osteoclastic differentiation potential. Osteoblast cells originating from PDL fibroblasts synthesize receptor activator of nuclear factor kappa‐B ligand (RANKL), and it is a quite realiable indicator for osteoclastic differentiation …”