Oesophageal motor function before and after healing of oesophagitis.

Singh, Pradip; Adamopoulos, Adam; Taylor, Renwick; Colin‐Jones, D G

doi:10.1136/gut.33.12.1590

Cited by 97 publications

(50 citation statements)

References 16 publications

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“…However, relapse is almost the rule in children with GORD after repaired oesophageal atresia or GORDassociated with connective tissue disorders and neurological disease [37]. In these children, oesophageal motor abnormalities persist after healing of the oesophagitis [36] and resemble that in adults [46,60,112,113,115,120].…”

Section: Pathophysiologymentioning

confidence: 99%

A critical appraisal of current management practices for infant regurgitation - recommendations of a working party

Vandenplas

Belli²,

Benhamou

et al. 1997

European Journal of Pediatrics

126

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A critical appraisal of current management practices for infant regurgitation: recommendations of a working party Vandenplas, Y.; Belli, D.; Benhamou, P.; Cadramel, S.; Cezard, J.P.; Cucchiara, S.; Dupont, C.; Faure, C.; Gottrand, F.; Hassall, E.; Heymans, H.S.A.; Kneepkens, C.M.F.; Sandhu, B. Published in:European Journal of Pediatrics DOI:10.1007/s004310050613Link to publication Citation for published version (APA):Vandenplas, Y., Belli, D., Benhamou, P., Cadramel, S., Cezard, J. P., Cucchiara, S., ... Sandhu, B. (1997). A critical appraisal of current management practices for infant regurgitation: recommendations of a working party. European Journal of Pediatrics, 156, 343-357. DOI: 10.1007/s004310050613 General rightsIt is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulationsIf you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Abstract Regurgitation is a common manifestation in infants below the age of 1 year and a frequent reason of counselling of general practitioners and paediatricians. Current management starts with postural and dietary measures, followed by antacids and prokinetics. Recent issues such as an increased risk of sudden infant death in the prone sleeping position and persistent occult gastrooesophageal reflux in a subset of infants receiving milk thickeners or thickened ''anti-regurgitation formula'' challenge the established approach. Therefore, the clinical practices for management of infant regurgitation have been critically evaluated with respect to their efficacy, safety and practical implications.

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Section: Pathophysiologymentioning

confidence: 99%

A critical appraisal of current management practices for infant regurgitation - recommendations of a working party

Vandenplas

Belli²,

Benhamou

et al. 1997

European Journal of Pediatrics

126

View full text Add to dashboard Cite

show abstract

“…Currently, the most reliable data is that the abnormalities of oesophageal motor function in patients with reflux oesophagitis do not improve after complete healing of oesophagitis (Singh et al,1992). This suggests that oesophageal dysmotility is a primary phenomenon and not a consequence of injury and inflammation.…”

Section: Wwwintechopencommentioning

confidence: 95%

“…Gill et al have reported shorter durations of contraction in this condition (Gill et al,1986). On the other hand, Singh et al have found a longer durations of contraction in patients with GERD compared with the controls (Singh et al,1992). Oesophageal transit and acid clearance have also been shown to be slower in these patients (Singh et al,1992).…”

Section: Wwwintechopencommentioning

confidence: 97%

“…On the other hand, Singh et al have found a longer durations of contraction in patients with GERD compared with the controls (Singh et al,1992). Oesophageal transit and acid clearance have also been shown to be slower in these patients (Singh et al,1992). In agreement with those observations Timmer et al found, comparing oesophageal motility in patients with low grade oesophagitis with motility data obtained in a matched normal control group, reduced propagation velocity and duration of peristaltic contractions, with www.intechopen.com increase in the number of non transmitted contractions in patients with grade I and II oesophagitis.…”

Section: Wwwintechopencommentioning

confidence: 99%

“…Patients with reflux oesophagitis have reduced lower oesophageal sphincter pressures (figure 1), an increased incidence of failed peristalsis (figure 2), reduced distal peristaltic amplitudes, slower velocity of propagation and in some studies shorter duration of contractions (Timmer et al,1994). Two groups have reported that healing of oesophagitis does not improve impaired oesophageal motility (Katz et al,1986, Singh et al,1992. An extension of the clearance time has been reported in about 50% of patients with esophagitis (Kahrilas, 1986).…”

Section: Wwwintechopencommentioning

confidence: 99%

See 2 more Smart Citations

Esophageal Motility and Gastroesophageal Reflux

Grande¹,

Villa²,

Cadeddu³

2012

Gastroesophageal Reflux Disease

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Antireflux Surgery Enhances Gastric Emptying

Viljakka

Saali²,

Koskinen³

et al. 1999

Arch Surg

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To evaluate the influence of antireflux surgery on gastric emptying.Design: Nonrandomized controlled trial 3 months before and after surgical intervention.Setting: Secondary and tertiary referral center.Patients and Control Subjects: Twenty consecutive patients (7 women, 13 men), mean age 49.2 years, with symptomatic, objectively confirmed gastroesophageal reflux disease and 10 healthy control subjects (3 women, 7 men), mean age 37.3 years. Intervention: Laparoscopic or open Nissen fundoplication (in 1 case Toupet 180°posterior hemifundoplication).Main Outcome Measures: Gastric emptying scintigraphy, using solid food, in control subjects and patients 3 months before and 3 months after the operation; time to halving of the maximal activity and the activity remaining at 60, 100, and 120 minutes.Results: Preoperative symptoms included pyrosis in 19 of 20 patients and regurgitation in 18. Three months postoperatively, 19 patients were symptom-free. The mean time to halving of the maximal activity decreased from 113 to 78 minutes (P = .001). Delayed gastric emptying was found postoperatively in 3 patients, compared with preoperative values, using activity at 60, 100, 120 minutes and the mean time to halving of the maximal activity as the variables. Compared with control subjects, gastric emptying was slower in patients preoperatively and faster postoperatively, but the difference was not statistically significant. Conclusion:Gastric emptying is enhanced after antireflux surgery, along with cessation of symptoms and healing of esophagitis.

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Oesophageal motor function before and after healing of oesophagitis.

Cited by 97 publications

References 16 publications

A critical appraisal of current management practices for infant regurgitation - recommendations of a working party

A critical appraisal of current management practices for infant regurgitation - recommendations of a working party

Esophageal Motility and Gastroesophageal Reflux

Antireflux Surgery Enhances Gastric Emptying

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