Oesophageal dysmotility in systemic sclerosis: comparison of HRCT and scintigraphy

Pitrez, Eduardo Hennemann; Bredemeier, Markus; Xavier, Ricardo Machado; Capobianco, Karina Gatz; Restelli, Vicente Gregório; Vieira, M V; Ludwig, Dieter; Brenol, João Carlos Tavares; Furtado, Álvaro Porto Alegre; Fonseca, Leila S.; Gutfilen, Bianca

doi:10.1259/bjr/17000205

Cited by 37 publications

(38 citation statements)

References 22 publications

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“…It is well known that the esophagus is dilated in systemic sclerosis (Bhalla et al 1993;Pitrez et al 2006;Vonk et al 2008;Patiwetwitoon et al 2012), but its precise measurements and association with lung disease had not been done before. The finding of retained food and liquid also indicates esophageal dysfunction.…”

Section: Discussionmentioning

confidence: 99%

“…While several studies reported the prevalence of esophageal dilation on chest CT scans for systemic sclerosis patients, these studies used empirical cutoff values to define esophageal dilation without regard to normal standards (Bhalla et al 1993;Pitrez et al 2006;Vonk et al 2008;Patiwetwitoon et al 2012).…”

Section: Introductionmentioning

confidence: 99%

“…It has been suggested that esophageal dysfunction and aspiration may play a role in pathogenesis of interstitial lung disease in systemic sclerosis and other lung diseases (el-Serag and Sonnenberg 1997; Tobin et al 1998;Marie et al 2001;Savarino et al 2009;Christmann et al 2010). Esophageal dilation on CT scan correlates well with esophageal dysfunction (Pitrez et al 2006;Vonk et al 2008). The CT image of esophagus, if correlated with function, has several practical advantages over conventional methods to evaluate esophageal dysfunction: availability, noninvasiveness, easy repeatability, and little need of patient cooperation.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Computed Tomography of the Esophagus in Scleroderma and Lung Disease

Takekoshi

Arami

Sheppard

et al. 2015

Tohoku J. Exp. Med.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Computed Tomography of the Esophagus in Scleroderma and Lung Disease

Takekoshi

Arami

Sheppard

et al. 2015

Tohoku J. Exp. Med.

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“…Routine diagnostics should include identifying specific symptoms in the patient' s history, abdominal ultrasound, upper and lower GI endocopy, an H2 breath test and even fecal calprotectin [59]. Esophageal dilatation, as seen with non-invasive HRCT, can function as a good predictor for esophagus dismotility and is superior to scintigraphy [60]. According to EULAR therapeutical recommendations, protonpump inhibitors (PPI) should be given for the prevention of gastic complications (GERD, ulcers, GAVE).…”

Section: Interstitial Lung Diseasementioning

confidence: 99%

Recent Advances in Systemic Scleroderma in Childhood

Constantin¹,

Zoltan²,

Foeldvari³

et al. 2014

Ann Paediatr Rheum

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“…[2][3][4][5][6][7][8][9] As an indicator of dysmotility in both early and advanced disease, a study has demonstrated that esophageal scintigraphy has a higher sensitivity than that of manometry and barium swallows [3], although new manometric techniques have been developed currently. However, the relationship between nuclear esophageal transit studies and reflux esophagitis has not been defined yet.…”

Section: Introductionmentioning

confidence: 99%

Esophageal transit scintigraphy and structured questionnaire in patients with systemic sclerosis with endoscopically proven reflux esophagitis

et al. 2009

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Objectives: Esophageal complication is common in patients with systemic sclerosis (SSc). The relationship between gastroesophageal reflux (GER) symptoms and dysmotility was examined in endoscopically confirmed patients with suspected of having reflux esophagitis. Methods: A total of 32 patients with limited and diffuse type SSc (lSSc, dSSc) were examined based on a structured questionnaire score (QS) of GER symptoms, retention fraction of esophageal scintigraphy at 90 seconds (R90) and gastric emptying time. Results: The QS was significantly higher in the reflux esophagitis group than in the nonesophagitis group (5.4 ± 3.5, 1.4 ± 2.9, p=0.003). When the non-esophagitis group was further divided into lSSc and dSSc groups, R90 was higher in the reflux esophagitis group (31% ± 18%) and the non-esophagitis group with dSSc (34% ± 32%) than in the non-esophagitis group with lSSc (8% ± 3%, p=0.02). Both high R90≥15% and QS≥4 indicated reflux esophagitis. Conversely both normal R90 and QS indicated no reflux esophagitis. Conclusion: A combination of esophageal scintigraphy and structured questionnaire demonstrated different aspects of esophageal dysfunction, namely dysmotility and GER. Patients with high QS and dysmotility may be indicated for further evaluation including endoscopic examination and medical treatment.

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Oesophageal dysmotility in systemic sclerosis: comparison of HRCT and scintigraphy

Cited by 37 publications

References 22 publications

Computed Tomography of the Esophagus in Scleroderma and Lung Disease

Computed Tomography of the Esophagus in Scleroderma and Lung Disease

Recent Advances in Systemic Scleroderma in Childhood

Esophageal transit scintigraphy and structured questionnaire in patients with systemic sclerosis with endoscopically proven reflux esophagitis

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