Oesophageal atresia and associated anomalies.

Chittmittrapap, Soottiporn; Spitz, Lewis; Kiely, Edward M.; Brereton, R.J.

doi:10.1136/adc.64.3.364

Cited by 169 publications

(99 citation statements)

References 19 publications

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“…identified 55%of his detectable malformations with 99% specificity and a false positive result of only 0.1 % in routine ultrasonography examinations. 10 Forty percent of our cases of EA had associated anomalies, a result similar to that reported by Chittmittrapap,5 and Spitz. Ultrasound diagnosis of EA was made at about 24 weeks of gestational age and was followed up by serial ultrasound antenatally.…”

Section: Discussionsupporting

confidence: 88%

Five Year Experience in Prenatal Ultrasound Diagnosis of Esophageal Atresia in Saudi Arabia

et al. 2003

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Background: Esophageal atresia (EA), with or without tracheoesophageal fistula (TOF) is one of themost correctable fetal anomalies if diagnosed antenatally by serial ultrasound. We retrospectivelyevaluated antenatal diagnoses by ultrasound of EA with or without TOF at our institution in SaudiArabia. Patients and Methods:We examined the records of mothers and infants with EA with or without TOFwho were booked early and delivered at our institution during 1994 to 1998. Fetal diagnosis wasbased on level II serial ultrasound using a high-resolution ultrasound machine (n=78). Results: In the 5-year period, there were 58 491 live births, with 1345 congenital abnormalities (2.3%)and 78 cases of EA with or without TOF (0.13%) diagnosed antenatally. The survival rate was 68% forwomen with vaginal deliveries and 60% for women with caesarean deliveries, so caesarean deliverydid not improve outcome. The Apgar score was 7 or greater at 5 minutes in 65 cases (83.5%), whichemphasizes the problems such patients develop after delivery. Death was caused by anomalies otherthan EA that were incompatible with life, or in the post-operative period, by septicemia, renal failure orcot death. Conclusions: Our study suggests that early antenatal booking, serial ultrasound and early antenataldiagnosis improves outcome in EA with or without TOF.

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Section: Discussionsupporting

confidence: 88%

Five Year Experience in Prenatal Ultrasound Diagnosis of Esophageal Atresia in Saudi Arabia

et al. 2003

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“…In four centres (Hainaut, Paris, Marseille, and Glasgow) 10 isolated cases were prenatally diagnosed where the outcome of pregnancy was a livebirth, 14-5% of all isolated cases in these centres.…”

Section: Prenatal Diagnosis and Induced Abortionmentioning

confidence: 99%

The epidemiology of tracheo-oesophageal fistula and oesophageal atresia in Europe. EUROCAT Working Group.

Depaepe

Dolk

Lechat

1993

Archives of Disease in Childhood

194

138

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“…It is usually associated with a tracheo-oesophageal fistula (TOF) [1,2] and affects approximately one in 2,500 live births [3]. The embryology of OA is incompletely understood [4], and over half these infants have associated anomalies [3,5]. The malformation itself and surgical trauma result in impaired oesophageal motility, a dysmotility predisposing to gastro-oesophageal reflux (GOR) and its complications [6,7].…”

mentioning

confidence: 99%

Repaired oesophageal atresia: respiratory morbidity and pulmonary function in adults

Sistonen¹,

Malmberg²,

Malmström³

et al. 2010

European Respiratory Journal

117

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Although after oesophageal atresia (OA) repair in infancy, respiratory problems are common, their natural history remains unclear. We assessed morbidity, pulmonary function (PF), and bronchial hyperresponsiveness (BHR) in adults with repaired OA respiratory.588 patients who underwent surgery for OA during 1947-1985 were identified and those 262 who were alive and had their native oesophagus were included. Respiratory symptoms and respiratory symptom-related quality of life (RSRQoL) were assessed by questionnaire and interview, and the patients underwent spirometry, a histamine challenge test, and an exhaled nitric oxide test. For the questionnaires, we added 287 carefully matched general populationderived controls.Among the 101 (58 male) patients, median age 36 yrs (range 22-56 yrs), respiratory morbidity was significantly increased compared to controls. Patients had more respiratory symptoms and infections, as well as asthma and allergies, and more often impaired RSRQoL (p,0.001 for all). PF tests revealed restrictive ventilatory defect in 21 (21%) patients, obstructive ventilatroy defect in 21 (21%) patients, and both in 36 (36%) patients. A total of 41 (41%) had BHR, and in 15 (15%), it was consistent with asthma. The most significant risk factors for restrictive ventilatory defect were thoracotomy-induced rib fusions (OR 3.4, 95% CI 1.3-8.7; p50.01) and oesophageal epithelial metaplasia (OR 3.0, 95% CI 1.0-8.9; p50.05).After repair of OA, respiratory-related morbidity, restrictive ventilatory defect and BHR extended into adulthood. Nearly half the patients had BHR and over half had a restrictive ventilatory defect. Thoracotomy-induced rib fusions and gastro-oesophageal reflux-associated oesophageal epithelial metaplasia were the strongest risk factors for restrictive ventilatory defect.

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Oesophageal atresia and associated anomalies.

Cited by 169 publications

References 19 publications

Five Year Experience in Prenatal Ultrasound Diagnosis of Esophageal Atresia in Saudi Arabia

Five Year Experience in Prenatal Ultrasound Diagnosis of Esophageal Atresia in Saudi Arabia

The epidemiology of tracheo-oesophageal fistula and oesophageal atresia in Europe. EUROCAT Working Group.

Repaired oesophageal atresia: respiratory morbidity and pulmonary function in adults

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