The epidemiology of tracheo-oesophageal fistula and oesophageal atresia in Europe. EUROCAT Working Group.

Depaepe, A; Dolk, Helen; Lechat, M. F.

doi:10.1136/adc.68.6.743

Cited by 194 publications

(165 citation statements)

References 8 publications

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“…35 This could be indicative of a cohort effect as the older mothers in this study and the younger mothers in the earlier European study were born in the 1960s. The increased risk of encephalocele among older mothers seems also to be counter to previous findings.…”

Section: Discussionmentioning

confidence: 87%

“…Older mothers have an increased risk of stillbirth and early miscarriage 38,39 and it is possible that this applies particularly to more vulnerable malformed fetuses. The increased risk of multiple births to mothers [35][36][37][38][39] years and the increased risk of congenital anomalies among multiple births (5% of our NCA cases were multiple births) also need further investigation in relation to older maternal age risks.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Maternal Age-Specific Risk of Nonchromosomal Anomalies

Loane

Dolk

Morris

2009

Obstetrical &Amp; Gynecological Survey

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Objectives To determine the excess risk of non-chromosomal congenital anomaly (NCA) among teenage mothers and older mothers.Design and setting Population-based prevalence study using data from EUROCAT congenital anomaly registers in 23 regions of Europe in 15 countries, covering a total of 1.75 million births from 2000 to 2004.Participants A total of 38 958 cases of NCA that were live births, fetal deaths with gestational age ‡20 weeks or terminations of pregnancy following prenatal diagnosis of a congenital anomaly.Main outcome measures Prevalence of NCA according to maternal age, and relative risk (RR) of NCA and 84 standard NCA subgroups compared with mothers aged 25-29. ResultsThe crude prevalence of all NCA was 26.5 per 1000 births in teenage mothers (<20 years), 23.8 for mothers 20-24 years, 22.5 for mothers 25-29 years, 21.5 for mothers 30-34 years, 21.4 for mothers 35-39 years and 22.6 for mothers 40-44 years. The RR adjusted for country for teenage mothers was 1.11 (95% CI 1.06-1.17); 0.99 (95% CI 0.96-1.02) for mothers 35-39; and 1.01 (95% CI 0.95-1.07) for mothers 40-44. The pattern of maternal age-related risk varied significantly between countries: France, Ireland and Portugal had higher RR for teenage mothers, Germany and Poland had higher RR for older mothers. The maternal age-specific RR varied for different NCAs. Teenage mothers were at a significantly greater risk (P < 0.01) of gastroschisis, maternal infection syndromes, tricuspid atresia, anencephalus, nervous system and digestive system anomalies while older mothers were at a significantly greater risk (P < 0.01) of fetal alcohol syndrome, encephalocele, oesophageal atresia and thanatophoric dwarfism.Conclusions Clinical and public health interventions are needed to reduce environmental risk factors for NCA, giving special attention to young mothers among whom some risk factors are more prevalent. Reassurance can be given to older mothers that their age in itself does not confer extra risk for NCA.

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Maternal Age-Specific Risk of Nonchromosomal Anomalies

Loane

Dolk

Morris

2009

Obstetrical &Amp; Gynecological Survey

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“…Moreover, the distal esophagus commonly connects to the trachea constituting a tracheoesophageal fistula (TEF) [1]. It is a relatively common congenital malformation occurring in 1:3000-4500 live births [2][3][4]. The etiology of this anomaly is likely to be multifactorial.…”

Section: Introductionmentioning

confidence: 99%

“…The procedure involves fistula ligation and esophageal anastomosis [6]. The standard approach is a right posterolateral, muscle-sparing thoracotomy in the 4th intercostal space [2][3][4][5][6][7]. The extrapleural approach is preferred by most of pediatric surgeons because the possible substantial anastomotic leak will not be complicated by empyema but mostly ends as anesophagocutaneous fistula, which usually closes in 1-2 weeks.…”

Section: Introductionmentioning

confidence: 99%

Balloon Dissection for Extra Pleural Approach in Tracheoesophageal Fistula Repair; A Novel Technique

Elqader¹,

Ghnnam²

2017

IJCTS

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Abstract:Objective: The extra-pleural approach for the tracheoesophageal fistula is preferred by most of pediatric surgeons because the possible substantial anastomotic leak will end in a fistula rather than an empyema. The problem with this technique that it is time consuming for pleural separation and liable for pleural tears. We studied a new method for using of Foley's catheter balloon to push the pleura away from the chest wall in an easier manner and shorter time. Method: A 25 neonate with tracheoesophageal fistula was managed with the extra-pleural approach using the Foley's catheter balloon as a method of pleural separation. Results: The mean time for pleural dissection was 4.5 m (266.4 sec) with a range of 2 m, 47 sec (167 sec) -6 m, 18 sec (378 sec). Only 4 minor pleural tears were encountered (16%) that passed smoothly. 4 Anastomotic leaks occurred that were managed conservatively and 2 mild Anastomotic strictures (8%) occurred and were managed conservatively. Conclusion: Balloon dissection is a valuable addition to management of esophageal atresia. It accomplishes pleural separation from the rib cage in short time and easy manner with nearly 0% incidence of significant pleural tears. Moreover, it improves the outcome of possible postoperative anastomotic leak without adding to the patient's morbidity or the hospital cost.

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“…In all, 206 pairs are described in the literature up until now; however, information on zygosity is less thorough. [9][10][11][12][13][14][15][16] Orford et al 15 stated that at least 80% of reported EA twins are same-sex pairs. In total, 22 out of these 206 twin pairs are concordant for the EA phenotype.…”

Section: Introductionmentioning

confidence: 99%

Copy number detection in discordant monozygotic twins of Congenital Diaphragmatic Hernia (CDH) and Esophageal Atresia (EA) cohorts

et al. 2011

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The occurrence of phenotypic differences between monozygotic (MZ) twins is commonly attributed to environmental factors, assuming that MZ twins have a complete identical genetic make-up. Yet, recently several lines of evidence showed that both genetic and epigenetic factors could have a role in phenotypic discordance after all. A high occurrence of copy number variation (CNV) differences was observed within MZ twin pairs discordant for Parkinson's disease, thereby stressing on the importance of post-zygotic mutations as disease-predisposing events. In this study, the prevalence of discrepant CNVs was analyzed in discordant MZ twins of the Esophageal Atresia (EA) and Congenital Diaphragmatic Hernia (CDH) cohort in the Netherlands. Blood-derived DNA from 11 pairs (7 EA and 4 CDH) was screened using high-resolution SNP arrays. Results showed an identical copy number profile in each twin pair. Mosaic chromosome gain or losses could not be detected either with a detection threshold of 20%. Some of the germ-line structural events demonstrated in five out of eleven twin pairs could function as a susceptible genetic background. For example, the 177-Kb loss of chromosome 10q26 in CDH pair-3 harbors the TCF7L2 gene (Tcf4 protein), which is implicated in the regulation of muscle fiber type development and maturation. In conclusion, discrepant CNVs are not a common cause of twin discordancy in these investigated congenital anomaly cohorts.

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The epidemiology of tracheo-oesophageal fistula and oesophageal atresia in Europe. EUROCAT Working Group.

Abstract: The total prevalence rate of tracheooesophageal fistula and oesophageal atresia in 15

Cited by 194 publications

References 8 publications

Maternal Age-Specific Risk of Nonchromosomal Anomalies

Maternal Age-Specific Risk of Nonchromosomal Anomalies

Balloon Dissection for Extra Pleural Approach in Tracheoesophageal Fistula Repair; A Novel Technique

Copy number detection in discordant monozygotic twins of Congenital Diaphragmatic Hernia (CDH) and Esophageal Atresia (EA) cohorts

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