Odoratin 7-O-β-D-glucopyranoside from Bowdichia virgilioides

Velozo, Leosvaldo S. M.; Silva, Bernadete P. da; Bernardo, Robson Roney; Parente, José Paz

doi:10.1016/s0031-9422(99)00459-8

Cited by 25 publications

(14 citation statements)

References 15 publications

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“…Previous study suggest that a compound of Bowdichia virgilioides named odoratin 7-O-␤-d-glucopyranoside may be a potential therapeutic agent in inflammatory/immunoregulatory disorders (Velozo et al, 1999), supporting the traditional use of Bowdichia virgilioides in Brazilian traditional medicine.…”

Section: Introductionmentioning

confidence: 89%

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Antinociceptive and anti-inflammatory activities of Bowdichia virgilioides (sucupira)

Thomazzi

Silva

Silveira

et al. 2010

Journal of Ethnopharmacology

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Section: Introductionmentioning

confidence: 89%

“…Previous chemical investigation of this plant has revealed the presence of flavonoids (Velozo et al, 1999), anthocyanin (Mell, 1929), benzofuranoids (Melo et al, 2001), essential oil (Arriaga et al, 1998), triterpenoids (Melo et al, 2001), resins (Machado, 1936), and alkaloids (Torrenegra et al, 1989).…”

Section: Introductionmentioning

confidence: 99%

Antinociceptive and anti-inflammatory activities of Bowdichia virgilioides (sucupira)

Thomazzi

Silva

Silveira

et al. 2010

Journal of Ethnopharmacology

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“…Phytochemical studies carried out on the bark and root materials have revealed the presence of tannins and lupeol (Calle et al 1983), alkaloids and terpenoids (Torrenegra et al 1985, Marinho et al 1994, volatile constituents and flavonoids (Arriaga et al 1998, Veloso et al 1999 and dihydrobenzofuran (Melo et al 2001). There were also reports of a novel alkaloid named bowdichine and two new isoflavonoids from the stem bark of this plant (Barbosa-Filho et al 2004, Juck et al 2006.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory effect of the ethanolic extract from Bowdichia virgilioides H.B.K stem bark

Barros

Rao

Silva

et al. 2010

An. Acad. Bras. Ciênc.

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Bowdichia virgilioides H.B.K stem bark (Fabaceae), locally known as "sucupira-preta", is a reputed folk-remedy to treat some inflammatory disorders. To validate its traditional claim, the ethanolic extract from B. virgilioides was evaluated in several animal models of inflammation and nociception. The extract at oral doses of 100 to 1000 mg/kg body weight caused a significant inhibition of carrageenan-induced hind paw oedema, suppression of exudate volume and leukocyte immigration in rat pleurisy induced by carrageenan, and reduction of granuloma weights in the model of subcutaneous granulomas promoted by cotton pellets. In addition, the plant extract significantly inhibited the vascular permeability increase induced by intraperitoneal acetic acid. It also showed marked antinociceptive effect in acetic acid-induced writhing test and in the second phase of formalin test in mice. These findings evidence the anti-inflammatory potential of Bowdichia virgilioides bark and supports its traditional use in inflammatory conditions.

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“…Various bioactivities, including antimalarial (Deharo et al, 2001), hypoglycemic (Barbosa-Filho et al, 2005) and inhibitor of the enzyme acetylcholinesterase (Barbosa-Filho et al, 2006), of crude extracts from this plant were reported. Previous chemical investigation resulted in the isolation of fl avonoids (Velozo et al, 1999a;Velozo et al, 1999b;Arriaga et al, 2000;Juck et al, 2006), benzofuranoids (Melo et al, 2001), essential oil (Arriaga et al, 1998), triterpenoids (Torrenegra et al, 1985;Marinho et al, 1994;Melo et al, 2001) and alkaloids (Torrenegra et al, 1985;Torrenegra et al, 1989;Marinho et al, 1994;Barbosa-Filho et al, 2004). This work describes the antimicrobial activity of the essential oil of Bowdichia virgilioides.…”

Section: Introductionmentioning

confidence: 92%