Odor perception in patients with mood disorders

Lombion-Pouthier, Sandrine; Vandel, Pierre; Nezelof, Sylvie; Haffen, Emmanuel; Millot, Jean-Louis

doi:10.1016/j.jad.2005.11.012

Cited by 149 publications

(176 citation statements)

References 28 publications

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“…Although the presence of active substance use has been associated with olfactory impairment (Rupp et al, 2003), there is no reason to suspect that a remote past history of substance abuse without dependence would impair olfactory abilities. The same applies to a past history of non-psychotic mood disturbance (Lombion-Pouthier et al, 2006). It should also be emphasized that only a minority of the unaffected family members in this study actually had histories of either mood disturbance or substance abuse.…”

Section: Discussionmentioning

confidence: 61%

Olfactory physiological impairment in first-degree relatives of schizophrenia patients

Turetsky

Kohler

Gur

et al. 2008

Schizophrenia Research

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Background-Efforts to characterize genetic vulnerability to schizophrenia are increasingly focused on the identification of endophenotypes -neurobiological abnormalities that are evident in individuals at risk. Behavioral studies have demonstrated olfactory impairments in odor detection and identification in unaffected 1 st -degree relatives of schizophrenia patients, suggesting that abnormalities in this simple sensory system may serve as candidate endophenotypes. It is unclear, however, whether these behavioral abnormalities reflect basic olfactory sensory processing deficits or nonspecific disruptions of attention and cognition.Method-Unirhinal chemosensory olfactory evoked potentials were acquired from 14 unaffected 1 st -degree relatives of schizophrenia patients and 20 healthy individuals with equivalent age and gender distributions, using 3 different concentrations of hydrogen sulfide. Subjects were also assessed behaviorally for ability to detect and identify odors.Results-Family members exhibited left nostril olfactory detection impairments and bilateral olfactory identification abnormalities. They had reduced evoked potential response amplitudes for the initial N1 component in the left nostril. The subsequent P2 evoked potential response was reduced bilaterally. The pattern and magnitude of family member deficits were comparable to those previously observed for schizophrenia patients.Conclusion-1 st -degree relatives of schizophrenia patients exhibit specific neurophysiological impairments in early olfactory sensory processing. The presence of these neurophysiological abnormalities in both schizophrenia patients and their unaffected 1 st -degree relatives suggests that these represent genetically mediated vulnerability markers or endophenotypes of the illness.

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Section: Discussionmentioning

confidence: 61%

Olfactory physiological impairment in first-degree relatives of schizophrenia patients

Turetsky

Kohler

Gur

et al. 2008

Schizophrenia Research

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“…The BDI used in the Greek study contains several somatic items 24 and thus has been criticized as a tool for the measurement of late-life depression. 25,26 Moreover, although some authors reported alterations in olfactory threshold in depressed psychiatric patients, [11][12][13][14] olfactory threshold was not assessed in the two studies on nonclinical older adults. 23,24 The primary purpose of the present study was to search for correlations between depressive symptoms measured by the Geriatric Depression Scale (GDS-15) and olfactory function (threshold and identification abilities) in non-clinical older adults.…”

mentioning

confidence: 97%

“…10,11,15,[18][19][20] Similarly, intensity ratings of various odors did not differ between psychiatric inpatients with depressive episode and control subjects. 11,12,17 In some of these studies, 12 positive correlations were found between olfactory deficits and the self-rated intensity of depressive symptoms assessed by the Beck Depression Inventory (BDI). 21 In contrast, olfactory measures were not correlated with the clinician-rated severity of depression measured with the Hamilton Depression Rating Scale (HAM-D).…”

mentioning

confidence: 99%

Depressive symptoms and olfactory function in older adults

Ścińska

Wróbel

Korkosz

et al. 2008

Psychiatry Clin Neurosci

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Aims: Neuroimaging studies suggest a significant overlap between brain regions involved in the regulation of olfaction and mood. The aim of the present study was to search for correlations between depressive symptomatology measured by the 15-item Geriatric Depression Scale (GDS) and olfactory function assessed with Sniffin' Sticks in non-demented older adults (aged 53-79 years).Methods: Taste detection thresholds were also measured by means of electrogustometry on the anterior tongue. Results:No correlation was found between the GDS scores (range: 0-12) and olfactory thresholds or olfactory identification scores. Similarly, there was no relationship between depressive symptoms and electrogustometric thresholds. Subjects (n = 25) scoring Ն5 on the GDS were classified as 'depressed' and all other individuals (n = 60) were classified as 'nondepressed'. The two groups did not differ in terms of the olfactory measures and electrogustometric threshold. Conclusion:Depressive symptoms are not associated with any major olfactory deficit in non-clinical older adults.

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“…No difference between the hedonic scores of MDD patients and controls was observed by three studies (Thomas et al, 2002;Swiecicki et al, 2009;Clepce et al, 2010). Other studies have found that MDD patients over-evaluate the pleasantness of odorants compared to controls (Lombion-Pouthier et al, 2006;Cumming et al, 2011).…”

Section: Olfactory Hedonic Response and Depressionmentioning

confidence: 83%

“…Another possible explanation of the inconsistent findings of the studies mentioned above is that some calculated the hedonic scores by taking all odours irrespective of their hedonic valence, and/or only pleasant stimuli were used (Lombion-Pouthier et al, 2006;Clepce et al, 2010). Differences in methodological approaches, the inclusion of depression subtypes (e.g.…”

Section: Olfactory Hedonic Response and Depressionmentioning

confidence: 99%

Hedonic Olfactory Perception in Depression: Relationship between Self-Evaluation and Autonomic Response

Atanasova¹,

Gaillard²,

Minier³

et al. 2012

PSYCH

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This study aimed to improve the understanding of hedonic perception in depression using the olfactory modality. We evaluated physiological (heart rate measures) and hedonic responses (subjective rating scale) obtained from 30 unipolar depressed inpatients and 30 healthy controls. The stimuli were two odorants with contrasting hedonic valence, vanillin (pleasant) and butyric acid (foul-smelling), presented at three different concentrations and in nine binary mixtures. Compared to controls, the depressed subjects had significantly increased heart rate response to olfactory stimuli, regardless of valence. These observations were not related to the severity of depression. For both groups, a significant negative correlation was found between the explicit hedonic rating and the implicit instantaneous heart rate measure. Together these pilot findings suggest that unipolar depression is associated with stronger physiological reactions to odorants and a negative bias when processing olfactory stimuli. Further studies are required to confirm these observations in larger groups of depressed subjects.

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Odor perception in patients with mood disorders

Cited by 149 publications

References 28 publications

Olfactory physiological impairment in first-degree relatives of schizophrenia patients

Olfactory physiological impairment in first-degree relatives of schizophrenia patients

Depressive symptoms and olfactory function in older adults

Hedonic Olfactory Perception in Depression: Relationship between Self-Evaluation and Autonomic Response

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