Odor Discrimination Requires Proper Olfactory Fast Oscillations in Awake Mice

Lepousez, Gabriel; Lledo, Pierre−Marie

doi:10.1016/j.neuron.2013.07.025

Cited by 151 publications

(194 citation statements)

References 48 publications

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“…In addition, this hypothesis agrees with the prominent recruitment of neurons within the OT upon odor presentation (Carlson et al 2013;Payton et al 2012;Rampin et al 2012). Among the spectral bands that have received the most attention in terms of being shaped by odor and odor quality, are beta and gamma (Cenier et al 2008;Lepousez and Lledo 2013;Lowry and Kay 2007;Martin et al 2006Martin et al , 2007. We found that the OT is also characterized by considerable beta-band power and detectable, yet minor, gamma-band power.…”

Section: Discussionmentioning

confidence: 74%

Odor- and state-dependent olfactory tubercle local field potential dynamics in awake rats

Carlson

Dillione

Wesson

2014

Journal of Neurophysiology

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The olfactory tubercle (OT), a trilaminar structure located in the basal forebrain of mammals, is thought to play an important role in olfaction. While evidence has accumulated regarding the contributions of the OT to odor information processing, studies exploring the role of the OT in olfaction in awake animals remain unavailable. In the present study, we begin to address this void through multiday recordings of local field potential (LFP) activity within the OT of awake, freely exploring Long-Evans rats. We observed spontaneous OT LFP activity consisting of theta- (2-12 Hz), beta- (15-35 Hz) and gamma- (40-80 Hz) band activity, characteristic of previous reports of LFPs in other principle olfactory structures. Beta- and gamma-band powers were enhanced upon odor presentation. Simultaneous recordings of OT and upstream olfactory bulb (OB) LFPs revealed odor-evoked LFP power at statistically similar levels in both structures. Strong spectral coherence was observed between the OT and OB during both spontaneous and odor-evoked states. Furthermore, the OB theta rhythm more strongly cohered with the respiratory rhythm, and respiratory-coupled theta cycles in the OT occurred following theta cycles in the OB. Finally, we found that the animal's internal state modulated LFP activity in the OT. Together, these data provide initial insights into the network activity of the OT in the awake rat, including spontaneous rhythmicity, odor-evoked modulation, connectivity with upstream sensory input, and state-dependent modulation.

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Section: Discussionmentioning

confidence: 74%

Odor- and state-dependent olfactory tubercle local field potential dynamics in awake rats

Carlson

Dillione

Wesson

2014

Journal of Neurophysiology

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“…If an SP cell responds with only 1–2 spikes for each round of input, it is more likely to respond faithfully to subsequent inputs. Such coupling may be important for maintaining any temporal coding feature present in beta/gamma oscillations (Laurent et al, 2001; Schaefer et al, 2006; Lepousez and Lledo, 2013) or for allowing the cortex to engage in its own oscillations (Freeman, 1959) that are coherent with those in the bulb (Bressler, 1984; Neville and Haberly, 2003). …”

Section: Discussionmentioning

confidence: 99%

“…Would silencing specific GABAergic cells disrupt odor-evoked cortical oscillations that may be driven by oscillatory bulbar inputs? Also, what impact would disrupting these detection mechanisms have on odor discrimination, which is significantly impacted by fast bulbar oscillations (Lepousez and Lledo, 2013)?…”

Section: Discussionmentioning

confidence: 99%

Matching of feedback inhibition with excitation ensures fidelity of information flow in the anterior piriform cortex

et al. 2014

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Odor-evoked responses in mitral cells of the olfactory bulb are characterized by prolonged patterns of action potential (spike) activity. If downstream neurons are to respond to each spike in these patterns, the duration of the excitatory response to one spike should be limited, enabling cells to respond to subsequent spikes. To test for such mechanisms, we performed patch-clamp recordings in slices of the mouse anterior piriform cortex. Mitral cell axons in the lateral olfactory tract (LOT) were stimulated electrically at different intensities and with various frequency patterns to mimic changing input conditions that the piriform cortex likely encounters in vivo. We found with cell-attached measurements that superficial pyramidal (SP) cells in layer 2 consistently responded to LOT stimulation across conditions with a limited number (1–2) of spikes per stimulus pulse. The key synaptic feature accounting for the limited spike number appeared to be somatic inhibition derived from layer 3 fast-spiking cells. This inhibition tracked the timing of the first spike in SP cells across conditions, which naturally limited the spike number to 1–2. These response features to LOT stimulation were, moreover, not unique to SP cells, also occurring in a population of fluorescently labeled interneurons in glutamic acid decarboxylase 65-eGFP mice. That these different cortical cells respond to incoming inputs with 1–2 spikes per stimulus may be especially critical for relaying bulbar information contained in synchronized oscillations at beta (15–30 Hz) or gamma

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“…OB gamma oscillations are produced by interactions between mitral/tufted cells and granule cells. A recent study using pharmacological manipulation of GABA A receptors specifically eliminated OB gamma oscillations and demonstrated that gamma oscillations are required for odor discriminations in vivo [127]. Gamma oscillations coupling across brain areas are important for odor information transfer and learning process [128].…”

Section: Theta and Gamma Oscillationsmentioning

confidence: 99%

Construction of functional neuronal circuitry in the olfactory bulb

Imai

2014

Seminars in Cell & Developmental Biology

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Recent studies using molecular genetics, electrophysiology, in vivo imaging, and behavioral analyses have elucidated detailed connectivity and function of the mammalian olfactory circuits. The olfactory bulb is the first relay station of olfactory perception in the brain, but it is more than a simple relay: olfactory information is dynamically tuned by local olfactory bulb circuits and converted to spatiotemporal neural code for higher-order information processing. Because the olfactory bulb processes ∼1000 discrete input channels from different odorant receptors, it serves as a good model to study neuronal wiring specificity, from both functional and developmental aspects. This review summarizes our current understanding of the olfactory bulb circuitry from functional standpoint and discusses important future studies with particular focus on its development and plasticity.

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Odor Discrimination Requires Proper Olfactory Fast Oscillations in Awake Mice

Cited by 151 publications

References 48 publications

Odor- and state-dependent olfactory tubercle local field potential dynamics in awake rats

Odor- and state-dependent olfactory tubercle local field potential dynamics in awake rats

Matching of feedback inhibition with excitation ensures fidelity of information flow in the anterior piriform cortex

Construction of functional neuronal circuitry in the olfactory bulb

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