Construction of functional neuronal circuitry in the olfactory bulb

Imai, Takeshi

doi:10.1016/j.semcdb.2014.07.012

Cited by 70 publications

(67 citation statements)

References 144 publications

(172 reference statements)

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“…A recent review highlights the important role that the olfactory bulb plays in helping to understand not only olfaction but how the brain develops and functions in general (Imai, 2014). In the human brain the olfactory bulb is situated underneath the anterior frontal lobe, whereas in non-human primates it can be the most anterior part of the brain, protruding inferiorly and slightly beyond the frontal lobe.…”

Section: Discussionmentioning

confidence: 99%

The average baboon brain: MRI templates and tissue probability maps from 89 individuals

et al. 2016

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The baboon (Papio) brain is a remarkable model for investigating the brain. The current work aimed at creating a population-average baboon (Papio anubis) brain template and its left/right hemisphere symmetric version from a large sample of T1-weighted magnetic resonance images collected from 89 individuals. Averaging the prior probability maps output during the segmentation of each individual also produced the first baboon brain tissue probability maps for gray matter, white matter and cerebrospinal fluid. The templates and the tissue probability maps were created using state-of-the-art, freely available software tools and are being made freely and publicly available: http://www.nitrc.org/projects/haiko89/ or http://lpc.univ-amu.fr/spip.php?article589. It is hoped that these images will aid neuroimaging research of the baboon by, for example, providing a modern, high quality normalization target and accompanying standardized coordinate system as well as probabilistic priors that can be used during tissue segmentation.

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Section: Discussionmentioning

confidence: 99%

The average baboon brain: MRI templates and tissue probability maps from 89 individuals

et al. 2016

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“…32 However, although we targeted the mitral cell layer in the electrophysiological recordings described above, we could not verify that the neural activity originated specifically from the M/Ts. 32 However, although we targeted the mitral cell layer in the electrophysiological recordings described above, we could not verify that the neural activity originated specifically from the M/Ts.…”

Section: Leptin Inhibits Odor-evoked Calcium Responses In Both M/tsmentioning

confidence: 99%

“…Since leptin receptors are expressed extensively in the granule cell layer of the OB, 9 and since there are strong interactions between mitral cells and granule cells, 32 we further tested whether leptin modulates the odor-evoked population activity of granule cells in awake mice. Using similar methods to those described above, we recorded the population calcium signal from genetically labeled granule cells.…”

Section: F I G U R Ementioning

confidence: 99%

Leptin modulates olfactory discrimination and neural activity in the olfactory bulb

Sun

Ke-ke

et al. 2019

Acta Physiologica

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Aim Leptin is an important peptide hormone that regulates food intake and plays a crucial role in modulating olfactory function. Although a few previous studies have investigated the effect of leptin on odor perception and discrimination in rodents, research on the neural basis underlying the behavioral changes is lacking. Here we study how leptin affects behavioral performance during a go/no‐go task and how it modulates neural activity of mitral/tufted cells in the olfactory bulb, which plays an important role in odor information processing and representation. Methods A go/no‐go odor discrimination task was used in the behavioral test. For in vivo studies, single unit recordings, local field potential recordings and fiber photometry recordings were used. For in vitro studies, we performed patch clamp recordings in the slice of the olfactory bulb. Results Behaviorally, leptin affects performance and reaction time in a difficult odor‐discrimination task. Leptin decreases the spontaneous firing of single mitral/tufted cells, decreases the odor‐evoked beta and high gamma local field potential response, and has bidirectional effects on the odor‐evoked responses of single mitral/tufted cells. Leptin also inhibits the population calcium activity in genetically identified mitral/tufted cells and granule cells. Furthermore, in vitro slice recordings reveal that leptin inhibits mitral cell activity through direct modulation of the voltage‐sensitive potassium channel. Conclusions The behavioral reduction in odor discrimination observed after leptin administration is likely due to decreased neural activity in mitral/tufted cells, caused by modulation of potassium channels in these cells.

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“…Within the mammalian olfactory bulb, olfactory sensory neurons (OSNs) transmit information onto output mitral cells (MCs) and various subpopulations of tufted cells (TCs) that differ in location of their cell bodies and arborization (Macrides and Schneider, 1982;Orona et al, 1984;Schoenfeld et al, 1985;Antal et al, 2006;Imai, 2014). Recent physiological studies have suggested that MCs and TCs in fact have quite distinct odor-evoked responses.…”

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confidence: 99%

Three‐dimensional synaptic analyses of mitral cell and external tufted cell dendrites in rat olfactory bulb glomeruli

Bourne

Schoppa

2016

J of Comparative Neurology

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Recent studies have suggested that the two excitatory cell classes of the mammalian olfactory bulb, the mitral cells (MCs) and tufted cells (TCs), differ markedly in physiological responses. For example, TCs are more sensitive and broadly tuned to odors than MCs and also are much more sensitive to stimulation of olfactory sensory neurons (OSNs) in bulb slices. To examine the morphological bases for these differences, we performed quantitative ultrastructural analyses of glomeruli in rat olfactory bulb under conditions in which specific cells were labeled with biocytin and 3,3’-diaminobenzidine. Comparisons were made between MCs and external TCs (eTCs), which are a TC sub-type in the glomerular layer with large direct OSN signals and capable of mediating feedforward excitation of MCs. Three-dimensional analysis of labeled apical dendrites under an electron microscope revealed that MCs and eTCs in fact have similar densities of several chemical synapse types including OSN inputs. OSN synapses also were distributed similarly, favoring a distal localization on both cells. Analysis of unlabeled putative MC dendrites further revealed gap junctions distributed uniformly along the apical dendrite, and, on average, proximal with respect to OSN synapses. Our results suggest that the greater sensitivity of eTCs versus MCs is not due to OSN synapse number or absolute location but rather a conductance in the MC dendrite that is well-positioned to attenuate excitatory signals passing to the cell soma. Functionally, such a mechanism could enable rapid and dynamic control of OSN-driven action potential firing in MCs through changes in gap junction properties.

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Construction of functional neuronal circuitry in the olfactory bulb

Cited by 70 publications

References 144 publications

The average baboon brain: MRI templates and tissue probability maps from 89 individuals

The average baboon brain: MRI templates and tissue probability maps from 89 individuals

Leptin modulates olfactory discrimination and neural activity in the olfactory bulb

Three‐dimensional synaptic analyses of mitral cell and external tufted cell dendrites in rat olfactory bulb glomeruli

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