Odor-avoidance or odor-preference induced by amphetamine in the infant rat depending on the dose and testing modality

Revillo, D.A.; Fernández, Gloria; Castelló, Stefanía; Paglini, María Gabriela; Arias, Carlos F.

doi:10.1016/j.bbr.2012.03.018

Cited by 4 publications

(3 citation statements)

References 44 publications

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“…The names of the groups allude to the solution that these groups received during the preexposure phase. Immediately afterwards, an intraoral cannula (PE 10 polyethylene tubing, length: 5 cm, Clay Adams, Parsippany, NJ) was implanted into the right cheek of each pup from groups P‐Sac and P‐Sal, as described previously (Arias, Molina, & Spear, ; Arias et al, ; Revillo, Fernandez, Castello, Paglini, & Arias, ). Briefly, the flanged end of the cannula was shaped by exposure to a heat source (external diameter: 1.2 mm).…”

Section: Methodsmentioning

confidence: 99%

“…On the conditioning day, all subjects consumed saccharin for 10 min using the procedures described for the preexposure phase, and were then immediately administered an intraperitoneal injection of LiCl (.15 M, 1% of body weight). This LiCl dose was selected from previous studies with preweanling rats, and produces consistent conditioned taste aversion with only one conditioning trial during the third postnatal week (Revillo et al, ; Revillo, Fernandez, et al, ). After conditioning, pups were returned to their home‐cage.…”

Section: Methodsmentioning

confidence: 99%

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Context‐dependent latent inhibition in preweanling rats

Revillo

Gaztañaga

Aranda

et al. 2014

Developmental Psychobiology

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Preexposure to a conditioned stimulus (CS) usually weakens conditioning, an effect known as latent inhibition. Similar to other learning interference effects, latent inhibition has been characterized as context-dependent, which means that the magnitude of this effect can be attenuated by changing the context between the different phases of the procedure (e.g., preexposure and conditioning). Latent inhibition has been found with a variety of procedures in infant rats, but the few studies that examined the context-dependency of this phenomenon during this ontogenetic period found no context-change effect. The present study explored the context-dependency of latent inhibition during infancy using a conditioned taste aversion preparation and employing contexts enriched with distinctive odors to increase the possible efficacy of the context manipulation. Experiment 1 showed that three preexposures to the CS (saccharin) were sufficient to retard conditioning to the same CS, although this effect was also observed in a control group preexposed to an alternative taste stimulus (saline), in comparison with a non-preexposed control group. In Experiment 2a, the CS-preexposure effect was found to be specific to the preexposed CS when the number of preexposures was increased. This effect was revealed as context-dependent in Experiment 2b, since it was attenuated by changing the context between preexposure and conditioning. The present result is consistent with recent studies showing the context-dependency of extinction in preweanling rats, thus demonstrating these animals' capacity to learn about context early on in their development.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Context‐dependent latent inhibition in preweanling rats

Revillo

Gaztañaga

Aranda

et al. 2014

Developmental Psychobiology

View full text Add to dashboard Cite

show abstract

“…The animals usually learn this association very quickly, making it a time-saving and efficient research method, which may be why only few attempts have been made to develop tests for this purpose using positive experiences. In studies where positive conditioning of odours has been applied, they involved pairing with psychostimulant drugs [6–8], alcohol [9] or a food source [10–12]. However, using feed as the unconditioned stimulus is not always feasible in practice, is likely to be associated with an increasing level of satiety, and psychoactive drugs alter mood and cognition [7].…”

Section: Introductionmentioning

confidence: 99%

Odour conditioning of positive affective states: Rats can learn to associate an odour with being tickled

et al. 2019

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Most associative learning tests in rodents use negative stimuli, such as electric shocks. We investigated if young rats can learn to associate the presence of an odour with the experience of being tickled (i.e. using an experimenter’s hand to mimic rough-and-tumble play), shown to elicit 50 kHz ultrasonic vocalisations (USVs), which are indicative of positive affect. Male, pair-housed Wistar rats (N = 24) were all exposed to two neutral odours (A and B) presented in a perforated container on alternate days in a test arena. Following 60s of exposure, the rats were either tickled on days when odour A (n = 8) or odour B (n = 8) was present, or never tickled (n = 8). When tickled, rats produced significantly more 50 kHz USVs compared to the days when not being tickled, and compared to control rats. The level of anticipatory 50 kHz USVs in the 60s prior to tickling did not differ significantly between the tickled and control rats. As a retrieval test following the odour conditioning, rats were exposed successively in the same arena to three odours: an unknown neutral odour, extract of fox faeces, and either odours A or B. Compared to controls, 50 kHz USVs of tickled rats increased when exposed to the odour they had previously experienced when tickled, indicating that these rats had learned to associate the odour with the positive experience of being tickled. In a test with free access for 5 min to both arms of a T-maze, each containing one of the odours, rats tickled with odour A spent more time in the arm with this odour. This work is the first to test in a fully balanced design whether rats can learn to associate an odour with tickling, and indicates that positive odour conditioning has potential to be used as an alternative to negative conditioning tests.

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Repeated amphetamine injections alter behavior and induce a delayed behavioral sensitization modulated by reactivity to novelty: Similarities and differences with trauma consequences

Toledano

Gisquet-Verrier

2016

European Neuropsychopharmacology

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Odor-avoidance or odor-preference induced by amphetamine in the infant rat depending on the dose and testing modality

Cited by 4 publications

References 44 publications

Context‐dependent latent inhibition in preweanling rats

Context‐dependent latent inhibition in preweanling rats

Odour conditioning of positive affective states: Rats can learn to associate an odour with being tickled

Repeated amphetamine injections alter behavior and induce a delayed behavioral sensitization modulated by reactivity to novelty: Similarities and differences with trauma consequences

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