Repeated amphetamine injections alter behavior and induce a delayed behavioral sensitization modulated by reactivity to novelty: Similarities and differences with trauma consequences

Toledano, Daniel; Gisquet-Verrier, Pascale

doi:10.1016/j.euroneuro.2015.12.042

Cited by 6 publications

(3 citation statements)

References 39 publications

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“…More recently, we showed that trauma vulnerable rats further exhibited a noradrenergic sensitization. Increases of NA releases in these rats were obtained, not only in response to an amphetamine injection known to stimulate the noradrenergic system, but also after a short exposure to a trauma reminder cue (Le Dorze et al, 2018), a finding previously obtained in rats repeatedly exposed to amphetamine injections (Toledano and Gisquet-Verrier, 2016). These findings strongly suggest trauma or drug experience involved similar physiological disruptions, resulting from exposure to extreme conditions.…”

Section: Ptsd and Sud: Two Pathologies Based On Common Physiological supporting

confidence: 68%

“…We demonstrated that, similar to mice, rats repeatedly exposed to amphetamine injections, as well as SPS vulnerable rats, developed long lasting behavioral sensitization (Toledano et al, 2013; Toledano and Gisquet-Verrier, 2014, 2016; Le Dorze and Gisquet-Verrier, 2016b). More recently, we showed that trauma vulnerable rats further exhibited a noradrenergic sensitization.…”

Section: Ptsd and Sud: Two Pathologies Based On Common Physiological mentioning

confidence: 63%

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Post Traumatic Stress Disorder and Substance Use Disorder as Two Pathologies Affecting Memory Reactivation: Implications for New Therapeutic Approaches

Gisquet-Verrier

Dorze

2019

Front. Behav. Neurosci.

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In the present review, we provide evidence indicating that although post traumatic stress disorder (PTSD) and substance use disorder (SUD) are two distinct pathologies with very different impacts on people affected by these chronic illnesses, they share numerous common characteristics, present high rates of co-morbidity, and may result from common physiological dysfunctions. We propose that these pathologies result from hyper reactivity to reminders, and thus should be considered as two disorders of memory, treated as such. We review the different possibilities to intervene on pathological memories such as extinction therapy and reconsolidation blockade. We also introduce new therapeutic avenues directly indicate by our recent proposal to replace the consolidation/reconsolidation hypothesis by the integration concept. State dependency and emotional remodeling are two innovative treatments that have already provided encouraging results. In summary, this review shows that the discovery of reactivation-dependent memory malleability has open new therapeutic avenues based on the reprocessing of pathological memories, which constitute promising approaches to treat PTSD and SUD.

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Section: Ptsd and Sud: Two Pathologies Based On Common Physiological supporting

confidence: 68%

Section: Ptsd and Sud: Two Pathologies Based On Common Physiological mentioning

confidence: 63%

Post Traumatic Stress Disorder and Substance Use Disorder as Two Pathologies Affecting Memory Reactivation: Implications for New Therapeutic Approaches

Gisquet-Verrier

Dorze

2019

Front. Behav. Neurosci.

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“…To examine the effects of traumatic stress on BLA physiology of male and female rats, we utilized the single-prolonged stress (SPS) model of PTSD. Previously research has shown SPS model produces amplified acoustic startle response ( Khan and Liberzon, 2004 ), longer time spent immobile during forced swim ( Wu et al, 2016 ), and defensive reactions to and avoidance of trauma-related cues ( Toledano and Gisquet-Verrier, 2016 ). In relation to neuroendocrine responses, SPS produces overactive and abnormal HPA-axis feedback ( Liberzon et al, 1997 ).…”

Section: Introductionmentioning

confidence: 99%

Sex Differences in the Physiological Response to Ethanol of Rat Basolateral Amygdala Neurons Following Single-Prolonged Stress

Ornelas

Keele

2018

Front. Cell. Neurosci.

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Females are more likely to develop post-traumatic stress disorder (PTSD) than males. Also, symptoms of PTSD frequently precede alcohol abuse in females. Stressful, threat-related stimuli are evaluated by the amygdala, which is critical for establishing the emotional salience of environmental stimuli. Ethanol and stress have been shown to modify amygdala excitability, but effects of acute ethanol on neurons of the basolateral amygdala (BLA) in both males and females exposed to stress is unknown. The purpose of this study is to determine stress-induced changes in membrane properties of BLA neurons and to determine how ethanol modulates these changes in male and female rats. Whole-cell recordings were obtained from BLA neurons of both male and female rats exposed to single-prolonged stress (SPS). Neuronal excitability, quantified as the number of action potentials, was determined in current clamp mode by applying a series of depolarizing current steps. Hyperpolarization-activated current (Ih) was elicited in voltage clamp. Excitability and Ih amplitude were determined before and during the superfusion of ethanol (EtOH; 30 mM) in BLA neurons from SPS-treated male and female rats. SPS alone did not alter the firing properties of BLA neurons from either males or females. However, following SPS, BLA neurons from males and females respond differently to ethanol. Superfusion of EtOH (30 mM) inhibited spike firing in BLA neurons from rats exposed to SPS, and EtOH-induced inhibition was greater in females than in males exposed to stress. Also, EtOH (30 mM) selectively decreased Ih amplitude in BLA neurons from SPS-treated male rats from 171 ± 46 pA in (pre-EtOH) control to 53 ± 51 pA in the presence of EtOH (30 mM). EtOH did not reduce Ih in BLA neurons from SPS-treated females. Together, these suggest important sex differences in the physiological responses to EtOH in stress disorders such as PTSD, that have high comorbidity with alcohol use disorders.

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Behavioral and Noradrenergic Sensitizations in Vulnerable Traumatized Rats Suggest Common Bases with Substance Use Disorders

Dorze¹,

Tassin²,

Chauveau³

et al. 2018

Mol Neurobiol

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The aim of the present study was to strengthen our hypothesis of a common physiological basis for post-traumatic stress disorder (PTSD) and substance use disorders. This paper investigates the possibility that rats exposed to a PTSD model exhibit noradrenergic and behavioral sensitization, as observed following repeated drugs of abuse injections. First, rats received a single prolonged stress (SPS), combining three consecutive stressors. They were then tested, 2 weeks after the trauma for PTSD-like symptoms to discriminate between vulnerable and resilient rats. When microdialysis was performed in the prelimbic cortex (Experiment 1), larger increases of noradrenaline (NA) release in response to amphetamine were observed in vulnerable rats when compared to control and resilient animals. Experiment 2 showed that trauma-vulnerable rats exhibited increases in locomotor activity relative to controls, in response to an exposure to trauma-associated cues. These data demonstrate that a single trauma exposure induces in vulnerable animals both, a noradrenergic sensitization evidenced within the prelimbic cortex and behavioral sensitization obtained after a physiologic activation of the noradrenergic system. However, Experiment 3 showed that when NA system was activated by amphetamine (1 mg/kg), a decrease in behavioral sensitization was obtained in vulnerable rats. We proposed that this decreased locomotor activity results from an additional stress-induced increased reactivity of mesocortical dopaminergic neurons, known to counteract the consequences of cortical noradrenergic release in rats. These results support our hypothesis that noradrenergic sensitization represents a common physiological basis, involved both in PTSD and drug addiction and suggest new common therapeutic approaches for these pathologies.

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Repeated amphetamine injections alter behavior and induce a delayed behavioral sensitization modulated by reactivity to novelty: Similarities and differences with trauma consequences

Cited by 6 publications

References 39 publications

Post Traumatic Stress Disorder and Substance Use Disorder as Two Pathologies Affecting Memory Reactivation: Implications for New Therapeutic Approaches

Post Traumatic Stress Disorder and Substance Use Disorder as Two Pathologies Affecting Memory Reactivation: Implications for New Therapeutic Approaches

Sex Differences in the Physiological Response to Ethanol of Rat Basolateral Amygdala Neurons Following Single-Prolonged Stress

Behavioral and Noradrenergic Sensitizations in Vulnerable Traumatized Rats Suggest Common Bases with Substance Use Disorders

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