Odontogenic tumours: 240 cases diagnosed over 31years at a Brazilian university and a review of international literature

Servato, João Paulo Silva; Prieto-Oliveira, P.; Faria, Paulo Rogério de; Loyola, Adriano Mota; Cardoso, Sérgio Vitorino

doi:10.1016/j.ijom.2012.05.008

Cited by 68 publications

(97 citation statements)

References 38 publications

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“…Corroborating with other studies (12,(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30), in our sample, benign tumors were prevalent. This low frequency of malignant tumors is similar to those reported in others countries (7)(8)(9)(10)(11)(12)19), but it is different than those reported in China that present more than 5% of cases as malignant tumors (16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29).…”

Section: Discussionsupporting

confidence: 91%

“…This low frequency of malignant tumors is similar to those reported in others countries (7)(8)(9)(10)(11)(12)19), but it is different than those reported in China that present more than 5% of cases as malignant tumors (16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29). We have observed a greater incidence of OTs in the female gender, result also found by Gaitán-Cepeda et al (30).…”

Section: Discussionsupporting

confidence: 87%

“…Furthermore, incidence herein obtained was higher (4.8%) than that found in other regions, which ranged from 1.3% to 3% (12,(18)(19)(20). These findings demonstrate that OTs have variable incidence worldwide and may present regional differences in a country with a continental dimension as Brazil.…”

Section: Discussionmentioning

confidence: 44%

“…Several retrospective studies of OTs published previously to the latest WHO classification (5) reported AMB and ODO being the most common tumors (7,13,19,29). However, the inclusion of KCOT has not only produced an increase in the frequency and prevalence of OTs, but also has modified the order of distribution of these tumors, making KCOT one of the most common OTs (18)(19)(20)(21)(22)30). OTs are uncommon lesions in the studied population and are represented mainly by the KCOT, AMB and ODO.…”

Section: Discussionmentioning

confidence: 99%

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Retrospective Study of 272 Odontogenic Tumors in a Brazilian Population

Silva

Tenório

Melo

et al. 2014

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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Background: Odontogenic tumors (OTs) are considered important among oral lesions because of their clinicopathological heterogeneity, and variable biological behavior. This paper aims to determine the frequency and distribution of OTs, over a period of 10 years, at a public university in Northeastern Brazil and compare this data with previous reports. Material and Methods: We reviewed all cases of OTs from oral pathology laboratory of University of Pernambuco (UPE), from 2004 to 2014. Diagnoses were re-evaluated and the tumors were classified according to the latest (2005) World Health Organization Classification of Tumors. In addition, we searched in the English-language literature retrospective studies on OTs that used the same classification. Results: Within the total of 6028 oral biopsies, 289 (4.79%) were OTs. Of these, 287 (99.3%) were benign and 2 (0.7%) were malignant. The overall incidence was 31.1/million. Mandible-maxilla ratio was 2.5:1 and mean age 35 years. Keratocystic odontogenic tumor (KCOT) (34.6%) was the most frequent lesion, followed by ameloblastoma (AMB) (32.9%) and odontoma (ODO) (11.4%). Conclusions: OTs are uncommon neoplasms with geographic variation. Our clinicopathological features are according to literature. In the present study, KCOT was the most frequent one, showing that the new classification of OTs altered the distribution of these lesions and possibly made KCOT the most common OT observed in diagnostic services worldwide.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 44%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Retrospective Study of 272 Odontogenic Tumors in a Brazilian Population

Silva

Tenório

Melo

et al. 2014

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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“…Studies that employed the 1992 classification usually reported odontomas as the highest prevalent odontogenic tumor in USA, Italy, Chile and Estonia and second highest in Iran, Turkey and third highest in India. In studies using the 2005 WHO classification, odontoma is second highest in Mexico and third highest in China, Libya, Brazil and Egypt [3].…”

Section: Discussionmentioning

confidence: 99%

An Erupted Silent Tumour

Kudva

Chithra

Rao

et al. 2015

J. Maxillofac. Oral Surg.

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Odontomas are the most common odontogenic tumors of the oral cavity which are nonaggressive, hamartomatous in nature consisting of enamel, dentin and cementum. They are called as composite because they contain more than one type of tissue. They are generally asymptomatic, hence recognised on routine radiologic examination. The compound odontoma is composed of multiple small tooth like structures, whereas the complex odontoma consists of a conglomerate mass of enamel and dentine, which bears no anatomical similarity to the tooth. The eruption and infection of odontoma are uncommon, only few cases of erupted complex odontoma are reported in the literature. We report a case of silent erupting complex odontoma.

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Clinicopathological and cell proliferation evaluation of ameloblastomas and keratocystic odontogenic tumors: a 10 year retrospective study

Silva

Serpa

Santana

et al. 2016

Eur Arch Otorhinolaryngol

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Odontogenic tumors (OTs) are important lesions of the gnathic bones due to their clinicopathological heterogeneity and variable biological behavior; therefore, epidemiological studies are needed to outline the incidence and behavior of these tumors. To evaluate the incidence and epidemiological profile of ameloblastoma (AMB) and keratocystic odontogenic tumor (KCOT) from an oral pathology service, and correlate morphological findings of these tumors with the immunoexpression of a cellular proliferation marker (Ki-67), a retrospective study (2002-2012) was conducted to characterize demographic, clinical, radiological, and morphological data of AMBs and KCOTs. Then, a representative sample composed of 49 cases of each tumor was selected to perform immunohistochemical (IHC) analysis of Ki-67 through the streptavidin biotin peroxidase technique. For statistical analysis, we used Fisher's exact test (p < 0.05). A total of 279 OTs were found in the service, in which 91 (32.6%) were AMB and 98 (35 %) were KCOT. Most cases occurred in white women, and the average age of patients with AMB and KCOT was 32 and 33 years, respectively. The maxilla-mandible ratio was 1:6 and 1:3.6 for AMB and KCOT, respectively. Regarding IHC analysis, AMB and KCOT had similar levels of cellular proliferation. However, KCOTs with intense inflammation showed higher Ki-67 expression (p < 0.001). Recurrent cases had similar Ki-67 immunoexpression. The demographic profile of the studied tumors corroborates with data reported in the literature, and the levels of cellular proliferation were similar in both tumors, although the inflammation seems to induce a differential proliferative behavior in KCOT.

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Odontogenic tumours: 240 cases diagnosed over 31years at a Brazilian university and a review of international literature

Cited by 68 publications

References 38 publications

Retrospective Study of 272 Odontogenic Tumors in a Brazilian Population

Retrospective Study of 272 Odontogenic Tumors in a Brazilian Population

An Erupted Silent Tumour

Clinicopathological and cell proliferation evaluation of ameloblastomas and keratocystic odontogenic tumors: a 10 year retrospective study

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