Odontogenic myxofibroma of gingiva in a pediatric patient with tuberous sclerosis: A rare case report

Abstract

Tuberous sclerosis complex (TSC) is a rare multisystem genetic disease, with an estimated incidence of 1 in 6000–1 in 10,000. TSC is an autosomal dominant syndrome involving heart, kidneys, lungs, and skin. The classic triad of TSC is seizures, mental retardation, and angiofibromas; this triad occurs in only 29% of patients. The clinical diagnostic guidelines on TSC are prepared based on clinical features, radiographic findings. The most common oral manifestations of TSC are fibroma, gingival hyperplasia, and enamel hypoplasia. Odontogenic myxofibroma represents a rare slow-growing benign neoplasm found rarely in children below 10 years or adults over 50 years of age. The prevalence of myxoma is between 0.04% and 3.7%. Here, we are reporting a rare case of myxofibroma of gingiva in an 8-year-old female TSC patient.

Odontogenic fibromyxoma: A case report in myasthenia gravis patient and review of the literature

“…When the literature was searched for the incidence of odontogenic fibromyxoma, no single incidence rate was found. Myxomas constitutes approximately 1–17.7 % of all odontogenic tumors and odontogenic fibromyxomas represent a very small part of all myxomas and their prevalence varies from 0.04 % to 3.7 % [1] , [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] .…”

“…Recent studies are considered to originate from primitive mesenchymal structures and are thought to arise from bone, tooth germ, or odontogenic tissues such as dental papilla, dental follicle or periodontal ligament. For this reason, we can say that all myxomas seen in the jaws are of odontogenic origin [7] , [8] , [9] , [10] , [11] , [13] , [14] , [15] , [16] , [17] , [20] , [23] , [24] , [25] , [26] , [27] , [28] , [29] .…”

“…It was observed that it peaked in the third decade. [2] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [16] , [17] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] . It is rarely seen in adults over 50 and children under 10 years of age [1] , [8] , [9] , [10] , [11] , [14] , [20] , [21] , [23] , [25] .…”

“…Odontogenic fibromyxoma causes enlargement of the jaws, usually bicortical bony expansion and often completely perforation of the cortices and extension into the surrounding structures but it rarely crosses the midline of the jaw [4] , [8] , [10] , [13] , [17] , [21] , [25] , [27] . Smaller lesions are usually asymptomatic, while larger lesions are often aggressive with the possible destruction of the cortical bone.…”

“…Since 1950, in the jaw, only 63 cases of odontogenic fibromyxoma (including the present case) have been published in the English-language literature ( Table 1 ) [1] , [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] . This study aimed to describe a case of fibromyxoma in a patient with myasthenia gravis and to review previously reported cases.…”