Odontogenic keratocyst: Analysis of recurrence by AgNOR, p53 and MDM2 profiling

Chandrashekar, Chetana; Patel, Pratik; Thennavan, Aatish; Radhakrishnan, Raghu

doi:10.4103/jomfp.jomfp_129_19

Cited by 4 publications

(3 citation statements)

References 23 publications

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Section: Discussionmentioning

confidence: 99%

“…Chandrashekar et al ( 2020 ) analyzed recurrence of OKC by AgNOR and two other markers. OKC is a developmental odontogenic cyst which is considered as a benign cystic neoplasm but it can behave aggressively and it has a propensity to recur (Chandrashekar et al, 2020 ). This study stated that there is a significant difference between recurrent and nonrecurrent group and AgNOR expression is higher in recurrent lesions.…”

Section: Discussionmentioning

confidence: 99%

“…Silver staining of AgNORs is considered as the best and most cost‐effective marker to evaluate the proliferative behavior of a lesion. The cell proliferation rate is evaluated by rapidity of the cell cycle and AgNOR count per nucleus (Chandrashekar et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the relationship between the expression of AgNOR and Ki67 with the recurrence rate in central granulomatous giant cell lesions: A case‐control

Dareh,

Andisheh‐Tadbir,

Aghakouchakzadeh

2024

Clinical & Exp Dental Res

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ObjectivesGiant cell granuloma is a local nonneoplastic lesion that is divided into two categories, based on its site of occurrence: Central and peripheral giant cell granuloma. Central giant cell granuloma is an intraosseous lesion that has a tendency to recure even in surgically treated cases. Several studies have proven that there is an association between different lesions clinical behavior and their histological features. The aim of this study was to evaluate the expression of AgNOR and Ki67 in lesions with and without recurrency.Material and MethodsFiles and records of 35 patients who had been histologically diagnosed with central giant cell granuloma were investigated. Histological features were studied after performing AgNOR staining and Ki67 marker. The data were analyzed by chi‐square, Fisher, and T‐test.ResultsAcquired data indicated that the count of AgNOR staining and Ki67 marker was significantly higher in lesions with recurrency than the lesions with no recurrency. The same results were attained from Ki67 intensity.ConclusionThe current study indicated that AgNOR staining and Ki67 marker have prognostic value in predicting recurrency of central giant cell granuloma lesions.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of the relationship between the expression of AgNOR and Ki67 with the recurrence rate in central granulomatous giant cell lesions: A case‐control

Dareh,

Andisheh‐Tadbir,

Aghakouchakzadeh

2024

Clinical & Exp Dental Res

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Long-term investigation of minimally invasive alcohol-based therapy as the treatment of odontogenic keratocyst:A retrospective cohort study

Li,

Xie,

et al. 2024

Journal of Cranio-Maxillofacial Surgery

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Novel recurrence risk stratification of odontogenic keratocysts: A systematic review

Titinchi

2021

Oral Diseases

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The aim of this study was to identify all clinical, radiological, histopathological, and immunohistochemical features associated with recurrence of odontogenic keratocysts (OKCs) in the literature and formulate a recurrence risk stratification based on these findings. A search was performed in PubMed/Medline, Scopus, Web of Science, Google Scholar and Cochrane databases for clinical and laboratory studies reporting on clinico‐pathological features that led to OKC recurrences for the period 2000 to 2020. Twenty‐three studies were identified and analyzed qualitatively. A total of 2064 OKCs were included of which 439 OKCs were recurrent with a mean follow‐up period of 46.7 months. Significantly associated parameters with OKC recurrence included age (variable age categories), large (>4 cm), multilocular lesions with cortical perforation, association with dentition, presence of daughter cysts, and epithelial budding. Immunohistochemical markers including high Ki67 index and AgNOR count were also implicated. A recurrence risk stratification was formulated based on these findings. Although the level of evidence from the included studies was low, there was considerable evidence that the clinico‐pathological parameters identified were linked with higher OKC recurrence. The surgeon, radiologist, and pathologist should aim to identify these features when making a diagnosis so as to determine the appropriate management regime and prevent recurrences.

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Odontogenic keratocyst: Analysis of recurrence by AgNOR, p53 and MDM2 profiling

Cited by 4 publications

References 23 publications

Evaluation of the relationship between the expression of AgNOR and Ki67 with the recurrence rate in central granulomatous giant cell lesions: A case‐control

Evaluation of the relationship between the expression of AgNOR and Ki67 with the recurrence rate in central granulomatous giant cell lesions: A case‐control

Long-term investigation of minimally invasive alcohol-based therapy as the treatment of odontogenic keratocyst:A retrospective cohort study

Novel recurrence risk stratification of odontogenic keratocysts: A systematic review

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