Ocular Vestibular-Evoked Myogenic Potential Amplitudes Elicited at 4 kHz Optimize Detection of Superior Semicircular Canal Dehiscence

Tran, Emma; Swanson, Austin; Sharon, Jeffrey D.; Vaisbuch, Yona; Blevins, Nikolas H.; Fitzgerald, Matthew B.; Steenerson, Kristen

doi:10.3389/fneur.2020.00879

Cited by 12 publications

(13 citation statements)

References 48 publications

(59 reference statements)

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“…Studies of the 4000Hz test in SCD patients have used a variety of rise-times including some very long rise-times -even 4ms as used in the Lin et al study [20]). Tran et al [19] and Batuecas-Caletrio et al [14] both used 2ms and our data indicate that with such risetimes it is likely that there would be no detectable oVEMP n10 in some patients. We consider that the lower sensitivity and specificity values for the 4000Hz test may have been due in part to the fact that they did not use an optimum rise-time for the 4000Hz stimulus.…”

Section: Rise-time In Clinical Vemp Testingmentioning

confidence: 49%

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A Single Fast Test for Semicircular Canal Dehiscence – oVEMP n10 to 4000Hz – Depends on Stimulus Rise-time

Curthoys¹,

Burgess²,

Manzari³

et al. 2022

Preprint

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We have previously reported that a single test measuring oVEMP n10 to 4000Hz stimuli (either bone-conducted vibration (BCV) or air-conducted sound (ACS)) provides a definitive diagnosis of semicircular canal dehiscence (SCD) in 22 CT-verified patients with a sensitivity of 1.0 and specificity of 1.0. Such a single short screening test has great advantages of speed, minimizing testing time and the exposure of patients to stimulation. However some studies of the 4000Hz test for SCD have reported sensitivity and sensitivity values somewhat less that what we reported.

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Section: Rise-time In Clinical Vemp Testingmentioning

confidence: 49%

“…Others have confirmed the high specificity and sensitivity of high frequency stimuli to be a very effective way of identifying SCD [14,17,19]. However there have been some reports where the measured specificity and sensitivity of the 4000Hz test for SCD has been lower than what Manzari et al found [19,20].…”

Section: Introductionmentioning

confidence: 92%

A Single Fast Test for Semicircular Canal Dehiscence – oVEMP n10 to 4000Hz – Depends on Stimulus Rise-time

Curthoys¹,

Burgess²,

Manzari³

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Other authors have confirmed the high specificity and sensitivity of high frequency stimuli to be a highly effective way of identifying SCD [ 14 , 17 , 19 ]. However, there have been some reports where the measured specificity and sensitivity of the 4000 Hz test for SCD has been lower than what was found by Manzari et al [ 19 , 20 ].…”

Section: Introductionmentioning

confidence: 83%

A Single Fast Test for Semicircular Canal Dehiscence—oVEMP n10 to 4000 Hz—Depends on Stimulus Rise Time

Curthoys

Burgess

Manzari³

et al. 2022

Audiology Research

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As previously reported, a single test measuring oVEMP n10 to 4000 Hz stimuli (bone-conducted vibration (BCV) or air-conducted sound (ACS)) provides a definitive diagnosis of semicircular canal dehiscence (SCD) in 22 CT-verified patients, with a sensitivity of 1.0 and specificity of 1.0. This single short screening test has great advantages of speed, minimizing testing time, and the exposure of patients to stimulation. However, a few studies of the 4000 Hz test for SCD have reported sensitivity and specificity values which are slightly less than reported previously. We hypothesized that the rise time of the stimulus is important for detecting the oVEMP n10 to 4000 Hz, similarly to what we had shown for 500 and 750 Hz BCV. We measured oVEMP n10 in 15 patients with CT-verified SCD in response to 4000 Hz ACS or BCV stimuli with rise times of 0, 1, and 2 ms. As a result, increasing the rise time of the stimulus reduced the oVEMP n10 amplitude. This outcome is expected from the physiological evidence of guinea pig primary vestibular afferents, which are activated by sound or vibration. Therefore, for clinical VEMP testing, short rise times are optimal (preferably 0 ms).

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“…The exact diagnostic accuracy depends on the chosen stimulus parameters, control groups, and the normal values defined in a particular study (for details, see also 167 168 169 170 ). The diagnostic accuracy can be further increased by measuring oVEMPs at 4 kHz 171 172 . While usually no VEMPs can be elicited at this frequency in an intact inner ear, a positive response indicates an SCD with a diagnostic accuracy > 90% ( Fig.…”

Section: Episodic Vestibular Syndromesmentioning

confidence: 99%

“… 167 168 169 170 ). Die diagnostische Genauigkeit lässt sich weiter steigern durch die Messung der oVEMPs bei 4 kHz 171 172 . Während sich für das Innenohr mit intakter otischer Kapsel bei diesen Frequenzen normalerweise keine oVEMPs mehr auslösen lassen, spricht der Nachweis von oVEMP-Antworten bei 4 kHz mit einer diagnostischen Genauigkeit von ca.…”

Section: 222 Symptome Und Untersuchungsbefundeunclassified

Seltene Erkrankungen des vestibulären Labyrinths: von Zebras, Chamäleons und Wölfen im Schafspelz

Dlugaiczyk

2021

Laryngorhinootologie

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ZusammenfassungDie Differenzialdiagnose von Erkrankungen des vestibulären Labyrinths stellt eine grosse Herausforderung dar, da sich hinter dem sehr häufigen Leitsymptom «Schwindel» viele verschiedene und v. a. seltene Erkrankungen verbergen können. Der vorliegende Beitrag gibt einen Überblick über die für den HNO-Arzt wichtigen seltenen Erkrankungen des vestibulären Labyrinths ausgehend von ihrer klinischen Präsentation als akutes (AVS), episodisches (EVS) oder chronisches vestibuläres Syndrom (CVS). Der Schwerpunkt liegt dabei auf den EVS, sortiert nach ihrer Dauer und dem Vorhandensein von Triggern (Sekunden, ohne Trigger: Vestibularisparoxysmie, Tumarkin-Krise; Sekunden, lärm- und druckinduziert: Syndrome des «dritten Fensters»; Sekunden bis Minuten, positionsabhängig: seltene Varianten und Differenzialdiagnosen des benignen paroxysmalen Lagerungsschwindels; Stunden bis Tage, spontan: intralabyrinthäre Schwannome, Tumoren des endolymphatischen Sacks, Autoimmunerkrankungen des Innenohres). Des Weiteren werden seltene Differenzialdiagnosen eines AVS (Neuritis vestibularis inf., Otolithenfunktionsstörungen, vaskuläre Ursachen, akute bilaterale Vestibulopathie) und eines CVS (bilaterale Vestibulopathie) erläutert. Dabei werden insbesondere die entscheidenden diagnostischen Massnahmen für die Identifikation der einzelnen Krankheitsbilder und die Warnzeichen für potentiell gefährliche Ursachen (z. B. Labyrinthinfarkt/-blutung) dargelegt. Somit dient dieser Beitrag dem HNO-Arzt in Klinik und Praxis als eine Art «Vademecum» für die zügige Identifikation und zeitnahe Therapie seltener Erkrankungen des Gleichgewichtsorgans.

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Ocular Vestibular-Evoked Myogenic Potential Amplitudes Elicited at 4 kHz Optimize Detection of Superior Semicircular Canal Dehiscence

Cited by 12 publications

References 48 publications

A Single Fast Test for Semicircular Canal Dehiscence – oVEMP n10 to 4000Hz – Depends on Stimulus Rise-time

A Single Fast Test for Semicircular Canal Dehiscence – oVEMP n10 to 4000Hz – Depends on Stimulus Rise-time

A Single Fast Test for Semicircular Canal Dehiscence—oVEMP n10 to 4000 Hz—Depends on Stimulus Rise Time

Seltene Erkrankungen des vestibulären Labyrinths: von Zebras, Chamäleons und Wölfen im Schafspelz

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