Ocular surface squamous neoplasia

Lee, Graham; Hirst, Lawrence W.

doi:10.1016/s0039-6257(05)80054-2

Cited by 588 publications

(589 citation statements)

References 125 publications

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“…Squamous cell carcinoma although, the most frequently encountered conjunctival malignancy is still an uncommon tumour of the conjunctiva [1,6] . The exact cause is not known.…”

Section: Discussionmentioning

confidence: 99%

“…Squamous cell carcinoma of the conjunctiva is the most frequently encountered conjunctival malignancy [1] . It is characterised by low grade aggressiveness that seldom leads to intraocular or intraorbital invasion [2][3][4] .…”

Section: Introductionmentioning

confidence: 99%

“…It is characterised by low grade aggressiveness that seldom leads to intraocular or intraorbital invasion [2][3][4] . It is slowly growing and occurs more commonly in the tropics than in temperate regions [1] . This has been attributed to the high ambient ultraviolet radiation found in the tropics [5] .…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of HIV seropositivity among patients with squamous cell carcinoma of the conjunctiva

Osahon

Ukponmwan

Uhunmwangho

2011

Asian Pacific Journal of Tropical Biomedicine

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“…Squamous cell carcinoma although, the most frequently encountered conjunctival malignancy is still an uncommon tumour of the conjunctiva [1,6] . The exact cause is not known.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence of HIV seropositivity among patients with squamous cell carcinoma of the conjunctiva

Osahon

Ukponmwan

Uhunmwangho

2011

Asian Pacific Journal of Tropical Biomedicine

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“…They are more frequent in countries located near the equator, with increased exposure to UV-B light, which is considered one of the main etiologic factors for the pathogenesis of the disease. 3 Only limited information is known about the molecular alterations that drive tumorigenesis.…”

Section: Discussionmentioning

confidence: 99%

“…Another important risk factor is immunosuppression, often due to human immunodeficiency virus (HIV) infection. 3,4 The role of human papilloma virus (HPV) in the pathogenesis of conjunctival squamous cell carcinoma remains controversial. 5,6 The tumors are locally invasive, with intraocular and orbital involvement reported in 2-15% and 12-16% of cases, respectively.…”

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confidence: 99%

Altered gene expression in conjunctival squamous cell carcinoma

et al. 2016

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Conjunctival squamous cell carcinoma is a malignancy of the ocular surface. The molecular drivers responsible for the development and progression of this disease are not well understood. We therefore compared the transcriptional profiles of eight snap-frozen conjunctival squamous cell carcinomas and one in situ lesion with normal conjunctival specimens in order to identify diagnostic markers or therapeutic targets. RNA was analyzed using oligonucleotide microarrays, and a wide range of transcripts with altered expression identified, including many dysregulated in carcinomas arising at other sites. Among the upregulated genes, we observed more than 30-fold induction of the matrix metalloproteinases, MMP-9 and MMP-11, as well as a prominent increase in the mRNA level of a calcium-binding protein important for the intracellular calcium signaling, S100A2, which was induced over 20-fold in the tumor cohort. Clusterin was the most downregulated gene, with an approximately 180-fold reduction in the mRNA expression. These alterations were all confirmed by qPCR in the samples used for initial microarray analysis. In addition, immunohistochemical analysis confirmed the overexpression of MMP-11 and S100A2, as well as reductions in clusterin, in several independent in situ carcinomas of conjunctiva. These data identify a number of alterations, including upregulation of MMP-9, MMP-11, and S100A2, as well as downregulation of clusterin, associated with epithelial tumorigenesis in the ocular surface.

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Human Immunodeficiency Virus Infection, Bcl-2, p53 Protein, and Ki-67 Analysis in Ocular Surface Squamous Neoplasia

Mahomed

Chetty²

2002

Arch Ophthalmol

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Objectives:To determine the age and human immunodeficiency virus (HIV) status of patients with ocular surface squamous neoplasia (OSSN), and to analyze tumor proliferation, Bcl-2, and p53 oncoprotein expression in OSSN. Methods:Only patients with histologically proved neoplasia were included in this study. The HIV status was obtained only with informed consent. Monoclonal antibodies to p53 and Bcl-2 protein were used after microwave antigen retrieval to enhance immunohistochemical staining of the sections. Proliferation was assessed by means of Ki-67 antigen expression. Positive staining in each specimen was expressed as a percentage and graded accordingly.Results: Forty-one eyes in 40 black patients with a mean age of 37 years were found to have OSSN. Of the 41 le-sions, 35 represented in situ or invasive carcinoma. The remaining 6 had mild or moderately dysplastic lesions. Seventeen patients agreed to an HIV test and, of these, 12 (70.6%) were HIV positive. All 12 were younger than 50 years, and 11 had either carcinoma in situ or invasive lesions. Twenty-two of 40 lesions expressed significant (greater than 50% of neoplastic cells) p53 positivity, while Bcl-2 expression was detected in 10. Ki-67 expression was low, even in the HIV-positive lesions.Conclusions: At our institution, OSSN occurs in young patients, many of whom are HIV positive. Expression of p53 is a common finding, whereas Bcl-2 immunoexpression occurs in the minority of cases. Ki-67 analysis showed that OSSN is a slow-growing tumor, even in the presence of HIV infection.

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Ocular surface squamous neoplasia

Cited by 588 publications

References 125 publications

Prevalence of HIV seropositivity among patients with squamous cell carcinoma of the conjunctiva

Prevalence of HIV seropositivity among patients with squamous cell carcinoma of the conjunctiva

Altered gene expression in conjunctival squamous cell carcinoma

Human Immunodeficiency Virus Infection, Bcl-2, p53 Protein, and Ki-67 Analysis in Ocular Surface Squamous Neoplasia

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