Ocular Side Effects of Amiodarone

Mäntyjärvi, Maija; Tuppurainen, Kari; Ikäheimo, Kirsi

doi:10.1016/s0039-6257(97)00118-5

Cited by 137 publications

(113 citation statements)

References 34 publications

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“…Verticillate keratopathy is the most commonly associated ocular change, occurring in about 70~100% of patients receiving amiodarone. 10,11 It may induce symptoms of glare, halos, or blurred vision. 2,11 Patients taking moderate to high dose of amiodarone may experience anterior subcapsular cataract.…”

Section: Ocular Changementioning

confidence: 99%

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Amiodarone-Associated Optic Neuropathy: Clinical Review

Wang

Cheng

2016

Neuro-Ophthalmology

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Amiodarone, an antiarrhythmic agent, has been associated with visual loss secondary to optic neuropathy. The reported mean duration of amiodarone use before visual loss is about 9 months. Patients receiving amiodarone have a 2-fold increased risk of developing optic neuropathy, especially in males and possibly in patients with longer duration of treatment. Amiodarone-associated optic neuropathy is characterised by an insidious onset, slow progression, bilateral simultaneous visual loss, and protracted disc swelling. After discontinuing amiodarone use, visual acuity and visual field deficits tend to improve or stabilise in most patients, with about 20% of the patients getting worse. ARTICLE HISTORY

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Section: Ocular Changementioning

confidence: 99%

“…10,11 It may induce symptoms of glare, halos, or blurred vision. 2,11 Patients taking moderate to high dose of amiodarone may experience anterior subcapsular cataract. 12 Maculopathy has also been reported in amiodraone uses.…”

Section: Ocular Changementioning

confidence: 99%

Amiodarone-Associated Optic Neuropathy: Clinical Review

Wang

Cheng

2016

Neuro-Ophthalmology

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“…Although our patient had good visual acuity, these findings prompted a detailed history and examination as to the indication for Amiodarone. These deposits are reversible and can resolve with cessation of amiodarone [7].…”

Section: Discussionmentioning

confidence: 99%

Corneal Manifestations of Chronic Systemic Drug Therapy

Yip¹,

Sanjay²

2011

J Clinic Experiment Ophthalmol

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“…A amiodarona, um antiarrítmico efetivo no controle de arritmias ventriculares e supraventriculares têm muitos efeitos colaterais documentados como: descoloração da pele, aumento da sensibilidade à luz, hepatite, disfunção tireoideana, fibrose pulmonar, supressão da medula óssea e depósitos corneanos (1) . Outros efeitos colaterais oculares relacionados ao nervo óptico, retina, cristalino e pálpebras têm sido descritos (2) . A ceratopatia induzida por amiodarona foi primeiramente descrita em 1968 (3) , e definida como depósitos marrom-dourados, arranjados linearmente em formato arboriforme ou de flores (whorl-shaped).…”

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“…A ceratopatia induzida por amiodarona foi primeiramente descrita em 1968 (3) , e definida como depósitos marrom-dourados, arranjados linearmente em formato arboriforme ou de flores (whorl-shaped). Os microdepósitos corneanos são o achado mais comum nos pacientes tratados com amiodarona (2) e, geralmente, são bilaterais e simétricos (4)(5) . Estes depósitos não alteram a acuidade visual e geralmente desaparecem após 3 a 20 meses de descontinuação da droga (6)(7) .…”

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