Ocular release of timolol from molecularly imprinted soft contact lenses

Hiratani, Haruyuki; Fujiwara, Akihito; Tamiya, Yuka; Mizutani, Yuri; Alvarez‐Lorenzo, Carmen

doi:10.1016/j.biomaterials.2004.04.030

Cited by 256 publications

(141 citation statements)

References 18 publications

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“…Therefore, it seems feasible that MIPs could form highly specific rate limiting reservoirs releasing active compounds at well-defined rates. Early studies delivered promising results and showed that these affinity materials could be used for the controlled delivery of drugs 16,17 or pesticides. 18 Such MIP containers may have some applications in medical patches, therapeutic wound healing, and various types of industrial tapes and coatings possessing a modulated retaining function for active substances.…”

mentioning

confidence: 99%

Influence of Polymer Morphology on the Capacity of Molecularly Imprinted Resins to Release or to Retain their Template

et al. 2009

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This paper deals with the specific ability of molecularly imprinted polymers (MIPs) to release and/or to retain their template. MIPs for caffeine with various MIP:porogen volume ratios were prepared by a non-covalent route. Formation of a prepolymerization complex between the template and the functional monomer was confirmed by nuclear magnetic resonance and computer simulation. The MIP monoliths were successively grinded, sieved, and dried under vacuum. The morphology of the imprinted particles was investigated by scanning electron microscopy, swelling experiments and nitrogen adsorption. Typical release patterns of as-synthesised MIP particles in solvents can be decomposed in three fractions: initial release ( 0 ), slow release over several hours (Á Release ), permanent retention/encapsulation within the MIP (Á Reservoir ). The effect of MIP:porogen volume ratio (related to the MIP porosity) on the releasing/retaining profiles of the materials has been investigated. Finally, the results were critically compared with the available literature and the applicability of MIP reservoirs is briefly discussed.KEY WORDS: Molecular Imprinting / Polymer Morphology / Controlled Release / Polymer Reservoir / Self-Assembly / Molecular imprinting is an emerging technology, which allows the molecular design of polymeric materials containing highly specific receptor sites with an affinity for target compounds.1-3 Formation of a self-assembled pre-polymerization complex between a template molecule and functional monomers, followed by polymerization with a cross-linker in a porogenic solvent and the subsequent extraction of the template, produces a molecularly imprinted polymer (MIP) possessing specifically sized and shaped cavities capable of molecular recognition. 4,5 MIPs are generally highly crosslinked thermosets, and therefore porosity is a necessary feature of their morphology to allow permeability and transport of templates molecules to the bulk polymer phase.To date, a number of promising applications have been proposed for MIPs. For instance, imprinted polymers are used in chromatography as the stationary phase for separation and isolation of racemates.6,7 A related area is solid-phase extraction, where imprinted polymers are employed as a selective sorbent to concentrate the molecule of interest.8 MIPs are also used in immunoassays-type analyses as synthetic antibody 9 and in catalysis as enzyme mimics. 10,11 In the emerging field of biosensors, MIPs demonstrate a potential as the recognition element, although their performance and selectivity in aqueous systems is still a limiting factor. 12,13The application of desorption properties of MIPs is a relatively new area.14,15 Chromatographic data have shown that the MIP-template dissociation kinetics can be controlled by varying the local environment (MIP composition, solvent. . .). Therefore, it seems feasible that MIPs could form highly specific rate limiting reservoirs releasing active compounds at well-defined rates. Early studies delivered promising results and showe...

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confidence: 99%

Influence of Polymer Morphology on the Capacity of Molecularly Imprinted Resins to Release or to Retain their Template

et al. 2009

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“…For instance, Hiratani et al have significantly improved loading of timolol in an imprinted hydrogel with respect to a non-imprinted polymer for ophthalmic delivery from soft contact lenses [19]. However, because the drug is required as the template and, as a consequence, the gels are already loaded with the drug during preparation, practical use will be in the efficient reloadability of the delivery system.…”

Section: Drug Deliverymentioning

confidence: 99%

Molecular imprinting: A new tool for drug innovation

Nostrum

2005

Drug Discovery Today: Technologies

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“…A group of scientists formulated a nanodiamond (ND)-embedded contact lens having the ability of lysozyme-triggered release of drugs for persistent therapy [38], here Timolol maleate was used as a model drug and the results showed that ND-embedded lenses provided prolonged delivery of TM making them promising tools for ocular drug delivery [38]. Ibrahim et al in 2015 formulated and tested the biodegradable nanoparticles with natural bioadhesives for ophthalmic application of Brimonidine in glaucoma management.…”

Section: Opthamologymentioning

confidence: 99%

“…Number of studies have been reported in past few years related to the efficacy and safety of various nanoparticles like cholesteroltethered platinum II-based supramolecular nanoparticle [37][38][39][40][41], polymeric-ceramic nanocarriers (NCs) in order to achieve oral delivery of the anticancer neutraceutical iron-saturated bovine lactoferrin (Fe-bLf) protein) [42,43], novel alginate-enclosed chitosan-calcium phosphate-loaded iron-saturated bovine lactoferrin nanocarriers for oral delivery in colon cancer therapy etc. [44][45][46][47][48][49][50].…”

Section: Introductionmentioning

confidence: 99%