Ocular Pulse Amplitude in Patients with Asymmetric Primary Open-Angle Glaucoma

Kac, Marcelo Jarczun; Solari, Helena Parente; Velarde, Guillermo Coca; Brazuna, Rodrigo; Cardoso, Gilberto Perez; Ventura, Marcelo Palis

doi:10.3109/02713683.2011.584652

Cited by 14 publications

(14 citation statements)

References 13 publications

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“…11 In addition, a well proven dependence of OPA on IOP both in glaucoma patients and controls has been reported with dynamic contour tonometry. 35,36 Interestingly, higher OPA was reported in eyes with higher IOP and more advanced disease in a study assessing fellow eyes of POAG patients, 37 however, higher OPA also correlates with less severe glaucomatous damage after controlling for IOP. 38 No differences were found in OPA values in different IOP levels between patients and controls.…”

Section: Discussionmentioning

confidence: 99%

Ocular Rigidity, Outflow Facility, Ocular Pulse Amplitude, and Pulsatile Ocular Blood Flow in Open-Angle Glaucoma: A Manometric Study

Dastiridou

Tsironi

Tsilimbaris

et al. 2013

Invest. Ophthalmol. Vis. Sci.

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Section: Discussionmentioning

confidence: 99%

Ocular Rigidity, Outflow Facility, Ocular Pulse Amplitude, and Pulsatile Ocular Blood Flow in Open-Angle Glaucoma: A Manometric Study

Dastiridou

Tsironi

Tsilimbaris

et al. 2013

Invest. Ophthalmol. Vis. Sci.

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“…As discussed previously, some patients may present with asymmetric POAG (13)(14)(15)(16)(17) . This prospective study investigated whether the IOP variation profile could be related to patients' current functional status.…”

Section: Discussionmentioning

confidence: 92%

“…Although it is a bilateral disease, many studies have re ported on asymmetric primary open-angle glaucoma (POAG) (13)(14)(15)(16)(17) . Although several factors possibly related to functional asymmetry between POAG eyes have been investigated (13)(14)(15)(16) , such an asymmetry could be explained in part by differences in the IOP profile between eyes. Although similar treated IOP values are expected during office visits between both eyes of a patient with POAG, long-term IOP variation parameters (fluctuation and peak), and especially those derived from provocative tests, could differ between eyes and justify an asymmetry in functional status.…”

Section: Introductionmentioning

confidence: 99%

Lack of association between provocative test-based intraocular pressure parameters and functional loss in treated glaucoma patients

Scoralick¹,

Gracitelli²,

Dias³

et al. 2019

Arquivos Brasileiros De Oftalmologia

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To correlate provocative test-based intraocular pressure (IOP) variation parameters (fluctuation and peak) with functional status, and to compare these IOP parameters between treated eyes with asymmetric primary open-angle glaucoma (POAG). Methods: A prospective observational study including consecutively treated patients with primary open-angle glaucoma was performed. Subjects with ocular diseases other than glaucoma or previous incisional glaucoma surgery were excluded. The primary inclusion criteria were ≥3 visual field tests and ≥2 years of follow-up, without any changes on current medical regimen. Long-term intraocular pressure parameters were acquired via isolated intraocular pressure measurements from the patients' last 5 office visits. To evaluate provocative test-based intraocular pressure parameters, all patients were submitted to a water drinking test. Initially, the partial correlation coefficients between each intraocular pressure variation parameter and visual field mean deviation were calculated, adjusting for the baseline intraocular pressure and number of antiglaucoma medications. In addition, each intraocular pressure parameter was compared between eyes with better visual field mean deviation and fellow eyes with worse visual field mean deviation in patients with asymmetric visual field loss (defined as an inter-eye visual field mean deviation difference of at least 3 dB). Results: A total of 87 eyes (87 patients; mean age, 61.9 ± 12.5 years; 59.8% women) with primary open-angle glaucoma were included. The patients underwent a median of 5 visual field tests, with a mean follow-up of 4.3 ± 1.4 years. Neither long-term nor water-drinking test intraocular pressure variation parameters were significantly associated with visual field mean deviation values (p≥0.117). In the subgroup with asymmetric visual field loss (64 eyes of 32 patients; mean age, 65.0 ± 11.4 years), neither long-term water-drinking test intraocular pressure variation parameters differed significantly between eyes with better and worse visual field mean deviation (p≥0.400). Conclusion: Our results indicate that neither long-term intraocular pressure variation parameters nor stress test-derived intraocular pressure metrics, as assessed by the water-drinking test, appear to correlate with the visual field status or differ significantly between eyes with asymmetric visual field damage, suggesting that other factors may explain such functional asymmetry, and that the water-drinking test does not add significant information to these cases.

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“…The glaucomatous defect or progression of the two eyes of the same patient was usually unbalanced, [1][2][3] suggesting different risk factors between the two eyes are taking effect. It is well known that intraocular pressure (IOP) changes with the body position.…”

Section: Introductionmentioning

confidence: 99%

Association between lateral decubitus sleeping position and asymmetric visual field loss and its progression in primary open-angle glaucoma patients

Lin

Pan

Wang

et al. 2019

Preprint

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Background: To investigate the association between lateral decubitus sleeping position (LDSP) and asymmetric visual field (VF) loss and progression in primary open-angle glaucoma (POAG) patients. Methods: This was a prospective, cohort study. Sixty-eight POAG (53 normal tension glaucoma, NTG) patients with asymmetric VF loss were included from the Wenzhou Glaucoma Screening Program (WGSP) and followed up. A questionnaire was used to determine the LDSP. Asymmetric VF loss was defined as at least 2-dB difference in mean deviation (MD) between the 2 eyes at baseline. According to these values, the better eye and worse eye were defined. The number of those preferring the worse eye LDSP versus the better eye LDSP was compared. The number of progressive eyes with LDSP and fellow eyes of LDSP were also compared. Results: Forty-five (66.2%) POAG and 34 (64.2%) NTG patients preferred the LDSP. Of these, 24 (53.3%, p=0.66) and 16 (47.1%, p=0.73) preferred the worse eye LDSP, respectively. Twenty-six eyes of the 45 POAG patients with both asymmetric VF loss and LDSP were judged as progression until the last follow-up (24.7 ± 9.5 months). Among which, there were 12 (46.2%) eyes with LDSP and 14 (53.8%) fellow eyes of LDSP (p=0.70). Conclusions: Approximately two thirds of the POAG/NTG patients preferred the LDSP. However, we could not draw the conclusion that lateral decubitus sleeping position is associated with asymmetric VF loss or glaucoma progression. Keywords: primary open-angle glaucoma; normal tension glaucoma; preferred sleeping position; asymmetric visual field defect

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Ocular Pulse Amplitude in Patients with Asymmetric Primary Open-Angle Glaucoma

Abstract: Higher OPA values were found in eyes with higher IOP levels and advanced glaucoma's lesions in asymmetric hypertensive POAG patients. However, after the OPA correction by the IOP levels there was no more statistical difference between eyes.

Cited by 14 publications

References 13 publications

Ocular Rigidity, Outflow Facility, Ocular Pulse Amplitude, and Pulsatile Ocular Blood Flow in Open-Angle Glaucoma: A Manometric Study

Ocular Rigidity, Outflow Facility, Ocular Pulse Amplitude, and Pulsatile Ocular Blood Flow in Open-Angle Glaucoma: A Manometric Study

Lack of association between provocative test-based intraocular pressure parameters and functional loss in treated glaucoma patients

Association between lateral decubitus sleeping position and asymmetric visual field loss and its progression in primary open-angle glaucoma patients

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