Ocular pulse amplitude in patients with Graves' disease, A preliminary study

Alimgil, Murat Levent; Benian, Ömer; Esgin, Haluk; Erda, Sait

doi:10.1034/j.1600-0420.1999.770618.x

Cited by 13 publications

(4 citation statements)

References 8 publications

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“…Several studies have concluded an increase in retinal blood flow and retinal artery resistance and a reduction in the peak systolic velocity (PSV) and end diastolic velocity (EDV) of the central retinal artery in GO patients [24][25][26]. However, Alimgil et al [27] revealed that ocular blood flow was significantly decreased in GO patients and claimed that this was the consequence of increased venous pressure and choroidal vessel resistance due to elevated intraorbital pressure. Technical differences and variation in patient status, such as inactive or active TAO state or moderate-to-severe degree of GO, might at least partially explain the discrepancy [28].…”

Section: Discussionmentioning

confidence: 99%

Analysis of Foveal and Parafoveal Microvascular Density and Retinal Vessel Caliber Alteration in Inactive Graves’ Ophthalmopathy

Akpolat

Kurt

Yılmaz

et al. 2020

Journal of Ophthalmology

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Purpose. We aimed to evaluate foveal and parafoveal density using optical coherence tomography angiography and the alteration on the retinal vessel diameter in patients with inactive Graves’ ophthalmopathy compared to age-matched normal population. Materials and Methods. Patients with inactive Graves’ ophthalmopathy (study group) and healthy individuals (control group) were enrolled in the cross sectionally designed study. The optical coherence tomography angiography parameters and retinal vessel diameter measurements were assessed between the study and control groups. Foveal and parafoveal microvascular density in the retina was measured using optical coherence tomography angiography. Retinal artery and vein diameter and artery/vein ratio were assessed for retinal vessel caliber changes. Results. Patients with inactive Graves’ ophthalmopathy had higher values of intraocular pressure, proptosis, and axial length (P=0.001, P=0.002, and P=0.008, respectively). Temporal parafoveal vessel density was 48.93 ± 3.21 and 47.62 ± 2.59 in the study and control groups, respectively (P=0.017). Nasal parafoveal vessel density was 47.55 ± 3.01 and 46.46 ± 2.57 in the study and control groups, respectively (P=0.035). Foveal, superior, and inferior parafoveal vessel density values were similar in the study and control groups (P=0.268, P=0.107, and P=0.055, respectively). Patients in the study group had narrower retinal artery and vein diameters (P≤0.001 and P=0.033). Artery/vein ratio was significantly higher in the control group (P≤0.001). Conclusion. Optical coherence tomography angiography could be a novel and promising noninvasive diagnostic technique in patients with inactive Graves’ ophthalmopathy to detect foveal and parafoveal vessel density changes compared to healthy subjects. The decrease of retinal vessel diameter might be observed in patients with inactive graves ophthalmopathy.

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Section: Discussionmentioning

confidence: 99%

Analysis of Foveal and Parafoveal Microvascular Density and Retinal Vessel Caliber Alteration in Inactive Graves’ Ophthalmopathy

Akpolat

Kurt

Yılmaz

et al. 2020

Journal of Ophthalmology

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“…Alimgil et al (15) showed that OPA in patients with TAO with pronounced orbital involvement is significantly lower compared to patients with TAO with no ocular involvement. According to Alimgil et al, reduced OPA could be due to orbital edema and swelling, which can cause a relative decrease of arterial filling facility of the choroid, or the increase of intraorbital pressure may prevent the eye from pulsating mechanically.…”

Section: Discussionmentioning

confidence: 99%

Ocular Pulse Amplitude in Patients with Thyroid-associated Ophthalmopathy

Božić

Knežević

Risimic

et al. 2012

European Journal of Ophthalmology

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“…Changes in ocular blood flow may alter the functions of the retina and retinal pigment epithelium and may affect the prognosis of different ophthalmological disorders, including TED. Ocular hemodynamic changes have been reported in GO by several authors using different techniques, including Heidelberg retina flowmeter, ocular blood flow tonography, and oculodynamometry [23][24][25]. In general, the numerous factors may cause alterations in ocular blood flow in patients with Graves' disease.…”

Section: Ultrasound-based Imaging Evaluation Of Graves' Ophthalmopathymentioning

confidence: 99%

Graves’ Ophthalmopathy Imaging Evaluation

Kawa¹,

Machalińska²,

Wilk³

et al. 2014

Thyroid Disorders - Focus on Hyperthyroidism

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Graves ophthalmopathy GO , known as Graves orbitopathy or thyroid eye disease TED , is an autoimmune disorder and the main extrathyroidal expression of Graves' disease GD . GO occurs mainly, but not exclusively, in patients with Graves disease up to % of GD patients have clinically apparent ophthalmopathy . The major clinical risk factor for developing thyroid eye disease is smoking. Moreover, radioactive iodine used to treat hyperthyroidism can worsen GO. There is an age-specific and gender-related distribution of GO, and the annual incidence is . % for women and . % for men but this largely reflects the increased incidence of GD in women [ ]. In addition to GD, thyroid eye disease can also be seen in chronic autoimmune thyroiditis, albeit is far less common and occurs in % of these patients [ ]. "lthough the link between GD and GO is still not totally clear, the close association between onset of GD and the development of GO suggests that both disorders would have common pathogenic mechanisms [ ]. The ocular involvement of GD is explained by the expression of receptor for thyroid-stimulating hormone TSH-R present not only in the thyroid follicular cells but also in adipocytes, and fibroblasts located in the orbit, and lymphocytes infiltrating orbit tissues [ ]. Likewise, the signs and symptoms of GO occur due to inflammatory reaction and subsequent fibrosis of the orbital components, including orbital connective tissue, and the extraocular muscles [ ]. Inflammatory cell infiltration of extraocular muscles is associated with increased secretion of glycosaminoglycans and osmotic retention of water. The muscles become enlarged, sometimes up to eight times their normal size, and may compress the optic nerve. Subsequent degeneration of muscle fibers eventually leads to fibrosis, which exerts a tethering effect on the involved muscle resulting in the muscle dysfunction and ophthalmoplegia. Infiltration of interstitial tissues, orbital fat and lacrimal glands with lymphocytes, plasma cells, macrophages and mast cells along with accumulation of glycosaminoglycans and

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Ocular pulse amplitude in patients with Graves' disease, A preliminary study

Cited by 13 publications

References 8 publications

Analysis of Foveal and Parafoveal Microvascular Density and Retinal Vessel Caliber Alteration in Inactive Graves’ Ophthalmopathy

Analysis of Foveal and Parafoveal Microvascular Density and Retinal Vessel Caliber Alteration in Inactive Graves’ Ophthalmopathy

Ocular Pulse Amplitude in Patients with Thyroid-associated Ophthalmopathy

Graves’ Ophthalmopathy Imaging Evaluation

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