Ocular Pulse Amplitude in Patients with Thyroid-associated Ophthalmopathy

Božić, Marija; Knežević, Miloš; Risimic, Dijana; Cubrilo, K.

doi:10.5301/ejo.5000161

Cited by 5 publications

(1 citation statement)

References 12 publications

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“…[9][10][11][12] In MS, a reduction of ocular blood flow in retro-orbital vessels had been shown by Doppler ultrasonography (USG); however, until now OPA in MS patients has not been reported. [13][14][15] In this study, we aimed to measure OPA and to determine any changes in choroidal perfusion in patients with MS. Another objective of this study was to evaluate RNFL changes in MS patients and to find out whether a past history of optic neuritis (ON) attack affects OPA and RNFL.…”

Section: Introductionmentioning

confidence: 99%

Decreased Ocular Pulse Amplitude and Retinal Nerve Fibre Layer in Multiple Sclerosis

Çetin¹,

Erdoǧan

Acer³

et al. 2013

Neuro-Ophthalmology

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This study was conducted to assess ocular pulse amplitude and retinal nerve fibre layer in patients with multiple sclerosis and their correlation with disease duration and with severity. Retinal nerve fibre layer thickness was measured by Heidelberg Retinal Tomography II (HRT-II; Heidelberg Engineering, Dossenheim, Germany) and ocular pulse amplitude was measured by dynamic contour tonometry (Ziemer Ophthalmic Systems, Port, Switzerland) in 37 multiple sclerosis patients and 72 age-and gender-matched controls. Ocular pulse amplitude was significantly reduced and retinal nerve fibre layer was significantly thinner in temporal, superotemporal, and nasal sectors in patients with multiple sclerosis regardless of having an optic neuritis attack. The retinal nerve fibre layer was thinner in eyes with a previous optic neuritis attack compared with the eyes without an attack, but the difference was not significant. Ocular pulse amplitude showed a positive correlation with visual evoked potential amplitude and a negative correlation with visual evoked potential latency. Retinal nerve fibre layer thickness showed a significant negative correlation with the disease duration but not with visually evoked potential, disease severity, nor previous optic neuritis. These findings indicate that the process of degeneration starts in the early period of the disease, as our study group is composed of earlymiddle-stage multiple sclerosis patients, and is independent of relapses.

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