Ocular Profile of Patients with Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma

Yousuf, Snober

doi:10.18535/jmscr/v6i11.115

Cited by 1 publication

(2 citation statements)

References 13 publications

(14 reference statements)

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“…42,43 These alterations also explain the wide range of complications that occur in association with intraocular surgery in patients with pseudoexfoliation syndrome, including zonular dehiscence, vitreous loss with posterior capsule rupture, iris hemorrhage, corneal endothelial decompensation, postoperative inflammation, peaks of ocular hypertension, secondary cataract and dislocation of intraocular implants. 43,44 In summary, it could be roughly described, the pathophysiology of the pseudoexfoliation syndrome is associated with excessive production of micro elastic fibrillin components, enzymatic processes, overexpression of TGF-B1, a proteolytic imbalance between MMPs and TIMPs, inflammatory process, increased oxidative and cellular stress as well as an insufficient cellular response to stress, which is reflected in poor regulation of antioxidative enzymes. The exact chemical composition of the pseudoexfoliation material is still unknown.…”

Section: Relationship Between Pseudoexfoliation Syndrome and Angle-cl...mentioning

confidence: 99%

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The role of the pseudoexfoliative syndrome as a transitional entity to glaucoma

Orozco

Gutiérrez²,

Zepeda³

et al. 2022

Int Surg J

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The balance between the secretion of aqueous humor by the ciliary body and its drainage through 2 independent pathways, the trabecular meshwork and the uveoscleral outflow pathway; and this will determine the intraocular pressure, which is considered the determining factor for glaucoma. Glaucoma is an entity of great clinical importance, being the second cause of blindness worldwide. There are different explanations for the pathophysiology of the disease, as well as immunological and vascular factors that lead to an increase in intraocular pressure, causing all these factors to trigger the development of glaucoma. Pseudoexfoliation syndrome can be defined as a systemic pathology that is generated by the deposition of extracellular fibrillar material in different tissues, and which, depending on the affected person, can cause different subsequent entities. Glaucoma progression and its sequelae may be more related to higher intraocular pressures than to other mechanisms. Various studies relate oxidative stress to glaucomatous progression. As the composition of the material causing pseudoexfoliation is further studied, its influence on the eye can be better understood.

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Section: Relationship Between Pseudoexfoliation Syndrome and Angle-cl...mentioning

confidence: 99%

“…However, the pathological process is characterized by the chronic accumulation of an abnormal fibrillar matrix product, which is also the result of excessive production or insufficient elimination, making it pathognomonic. [43][44][45][46][47][48][49][50]…”

Section: Relationship Between Pseudoexfoliation Syndrome and Angle-cl...mentioning

confidence: 99%