Staghorn stones are large branching stones that fill part of the entire renal pelvis and calyces and can be complete or partial depending on the degree of occupation of the collecting system. Although kidney stones are more common in men, coral stones are reported less frequently in men than in women and are usually unilateral. Due to the significant morbidity and potential mortality attributed to staghorn stones, prompt evaluation and treatment are imperative. In general, the gold standard treatment for coral stones is surgical treatment to achieve a stone-free collecting system and preserve renal function.
The balance between the secretion of aqueous humor by the ciliary body and its drainage through 2 independent pathways, the trabecular meshwork and the uveoscleral outflow pathway; and this will determine the intraocular pressure, which is considered the determining factor for glaucoma. Glaucoma is an entity of great clinical importance, being the second cause of blindness worldwide. There are different explanations for the pathophysiology of the disease, as well as immunological and vascular factors that lead to an increase in intraocular pressure, causing all these factors to trigger the development of glaucoma. Pseudoexfoliation syndrome can be defined as a systemic pathology that is generated by the deposition of extracellular fibrillar material in different tissues, and which, depending on the affected person, can cause different subsequent entities. Glaucoma progression and its sequelae may be more related to higher intraocular pressures than to other mechanisms. Various studies relate oxidative stress to glaucomatous progression. As the composition of the material causing pseudoexfoliation is further studied, its influence on the eye can be better understood.
Among the most feared toxico-dermas is drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome, a rare drug dermatitis that occurs after acute exposure to drugs whose clinical impact is based on multiple organs (skin, liver, kidneys, lungs, heart) and cell lines (eosinophils and lymphocytes). It is an entity with high mortality if it is not identified early, its treatment consists of the immediate suspension of the responsible drug and the administration of steroids, these being the therapeutic protagonists. A 64-year-old male patient with clinical, biochemical and histopathological criteria compatible with DRESS syndrome. It is essential to suspect the clinical course of DRESS syndrome before the appearance of dermatosis with multisystem involvement associated with the use of drugs, emphasis is placed on its early identification and the establishment of timely treatment to modify its prognosis.
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