Ocular permeability, intraocular biodistribution of lipid nanocapsule formulation intended for retinal drug delivery

Enhancing paracellular and transcellular permeability using nanotechnological approaches for the treatment of brain and retinal diseases

“…Surprisingly, the literature on LNPs for ocular permeability and retinal drug delivery is very limited. The team of Schipper and Paquet-Durand used LNCs to deliver CN03, a cGMP analogue, for the treatment of retinal degeneration, 55 but the drug permeation through the cornea proved to be too low for further clinical considerations. However, INV application of 2 mg mL −1 of fluorescently labeled LNCs ( d = 48–72 nm, ζ = −0.3 to −11 mV) and liposomes showed promising improvements (Fig.…”