Enhancing paracellular and transcellular permeability using nanotechnological approaches for the treatment of brain and retinal diseases

Khalil, Asmaa; Barras, Alexandre; Boukherroub, Rabah; Tseng, Ching-Li; Devos, David; Burnouf, Thierry; Neuhaus, Winfried; Szunerits, Sabine

doi:10.1039/d3nh00306j

Cited by 6 publications

(3 citation statements)

References 185 publications

(228 reference statements)

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“…Under physiological conditions, substances can enter the brain through passive transport, including paracellular pathways and passive diffusion ( Figure 2 ). However, tight junctions between endothelial cells prevent 98% of the small molecules and all large molecules from entering the brain via paracellular pathways ( Khalil et al, 2023 ). Additionally, the semi-permeability of the BBB allows only oxygen, carbon dioxide, and water to enter through passive diffusion ( Khalil et al, 2023 ).…”

Section: The Delivery Mechanisms Of Nanoparticle Drug Delivery Systemsmentioning

confidence: 99%

“…However, tight junctions between endothelial cells prevent 98% of the small molecules and all large molecules from entering the brain via paracellular pathways ( Khalil et al, 2023 ). Additionally, the semi-permeability of the BBB allows only oxygen, carbon dioxide, and water to enter through passive diffusion ( Khalil et al, 2023 ). Overall, this method is unsuitable under normal physiological conditions.…”

Section: The Delivery Mechanisms Of Nanoparticle Drug Delivery Systemsmentioning

confidence: 99%

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Progress of nanoparticle drug delivery system for the treatment of glioma

Lai,

Wu,

Yang

et al. 2024

Front. Bioeng. Biotechnol.

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Gliomas are typical malignant brain tumours affecting a wide population worldwide. Operation, as the common treatment for gliomas, is always accompanied by postoperative drug chemotherapy, but cannot cure patients. The main challenges are chemotherapeutic drugs have low blood-brain barrier passage rate and a lot of serious adverse effects, meanwhile, they have difficulty targeting glioma issues. Nowadays, the emergence of nanoparticles (NPs) drug delivery systems (NDDS) has provided a new promising approach for the treatment of gliomas owing to their excellent biodegradability, high stability, good biocompatibility, low toxicity, and minimal adverse effects. Herein, we reviewed the types and delivery mechanisms of NPs currently used in gliomas, including passive and active brain targeting drug delivery. In particular, we primarily focused on various hopeful types of NPs (such as liposome, chitosan, ferritin, graphene oxide, silica nanoparticle, nanogel, neutrophil, and adeno-associated virus), and discussed their advantages, disadvantages, and progress in preclinical trials. Moreover, we outlined the clinical trials of NPs applied in gliomas. According to this review, we provide an outlook of the prospects of NDDS for treating gliomas and summarise some methods that can enhance the targeting specificity and safety of NPs, like surface modification and conjugating ligands and peptides. Although there are still some limitations of these NPs, NDDS will offer the potential for curing glioma patients.

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Section: The Delivery Mechanisms Of Nanoparticle Drug Delivery Systemsmentioning

confidence: 99%

Section: The Delivery Mechanisms Of Nanoparticle Drug Delivery Systemsmentioning

confidence: 99%

Progress of nanoparticle drug delivery system for the treatment of glioma

Lai,

Wu,

Yang

et al. 2024

Front. Bioeng. Biotechnol.

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“…The intestinal mucosal barrier comprises mechanical, chemical, immune, and biological barriers (19), with the mechanical and immune barriers being the most critical. The intestinal epithelial mechanical barrier is formed of epithelial cells, including structures like tight junctions, mucinous junctions, desmosomes, and interstitial junctions, among which tight junctions are pivotal in preventing epithelial cell bypass (20). Tight junction complexes consist of various transmembrane proteins, such as the claudin, occludin, and connexin family of proteins.…”

Section: Effects Of Intestinal Microorganisms On the Intestinal Mucos...mentioning

confidence: 99%

Review of yeast culture concerning the interactions between gut microbiota and young ruminant animals

Liu,

Yang,

Zhang

et al. 2024

Front. Vet. Sci.

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Microorganisms inhabit the gastrointestinal tract of ruminants and regulate body metabolism by maintaining intestinal health. The state of gastrointestinal health is influenced not only by the macro-level factors of optimal development and the physiological structure integrity but also by the delicate equilibrium between the intestinal flora and immune status at the micro-level. Abrupt weaning in young ruminants causes incomplete development of the intestinal tract resulting in an unstable and unformed microbiota. Abrupt weaning also induced damages to the microecological homeostasis of the intestinal tract, resulting in the intestinal infections and diseases, such as diarrhea. Recently, nutritional and functional yeast culture has been researched to tackle these problems. Herein, we summarized current known interactions between intestinal microorganisms and the body of young ruminants, then we discussed the regulatory effects of using yeast culture as a feed supplement. Yeast culture is a microecological preparation that contains yeast, enriched with yeast metabolites and other nutrient-active components, including β-glucan, mannan, digestive enzymes, amino acids, minerals, vitamins, and some other unknown growth factors. It stimulates the proliferation of intestinal mucosal epithelial cells and the reproduction of intestinal microorganisms by providing special nutrient substrates to support the intestinal function. Additionally, the β-glucan and mannan effectively stimulate intestinal mucosal immunity, promote immune response, activate macrophages, and increase acid phosphatase levels, thereby improving the body’s resistance to several disease. The incorporation of yeast culture into young ruminants’ diet significantly alleviated the damage caused by weaning stress to the gastrointestinal tract which also acts an effective strategy to promote the balance of intestinal flora, development of intestinal tissue, and establishment of mucosal immune system. Our review provides a theoretical basis for the application of yeast culture in the diet of young ruminants.

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Ophthalmic Tethered Gold Yarnball‐Mediated Retained Drug Delivery for Eye Fundus Disease Treatment

Chou,

Yang,

Chiang

et al. 2024

Small Science

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Eye fundus diseases, such as retinal degenerative diseases, which lead to blindness in ≈12% of individuals aged >65 years, cause permanent damage to retinal cells. The antioxidant quercetin (QC) is promising for the effective treatment of eye fundus diseases; however, its poor solubility and low retention rate often limit its clinical application. Herein, an in situ ophthalmic tethered gold yarnball (GY) that doubles as an ocular retention agent and QC reservoir to overcome low fundus drug retention is developed. After intravitreal injection, QC@GYs enhance retinal cell leakage and internal limiting membrane permeability, facilitating the partial penetration of QC@GYs into the intraretinal tissue. The combination of retina‐tethered QC@GY and first‐level sustained release reduces macular degeneration in vivo by effectively regulating oxidative stress. Furthermore, the sustained release of QC preserves the viability of retinal pigment epithelium cells, reduces apoptosis, and suppresses drusen formation. This preservation of retinal morphology and function maximizes the therapeutic impact while minimizing the need for frequent intraocular administration. Overall, the ophthalmic tethered GY platform is a versatile tool for retinal drug delivery for the treatment of eye fundus diseases.

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Enhancing paracellular and transcellular permeability using nanotechnological approaches for the treatment of brain and retinal diseases

Abstract: Discussion on how to overcome the current failures of synthetic and cell-derived nanomaterials to bypass or temporally open tight junctions of the brain and the eye using recent advancements in various nanotechnological strategies.

Cited by 6 publications

References 185 publications

Progress of nanoparticle drug delivery system for the treatment of glioma

Progress of nanoparticle drug delivery system for the treatment of glioma

Review of yeast culture concerning the interactions between gut microbiota and young ruminant animals

Ophthalmic Tethered Gold Yarnball‐Mediated Retained Drug Delivery for Eye Fundus Disease Treatment

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