Ocular perfusion pressure in glaucoma

Costa, Vital Paulino; Harris, Alon; Anderson, Douglas R.; Stodtmeister, Richard; Cremasco, Fernanda; Kergoat, Hélène; Lovasik, John V.; Stalmans, Ingeborg; Zeitz, Oliver; Lanzl, Ines; Gugleta, Konstantin; Schmetterer, Leopold

doi:10.1111/aos.12298

Cited by 195 publications

(144 citation statements)

References 181 publications

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“…1,[33][34][35][36] Since the interrelation between OPP, ocular blood flow, and glaucoma is beyond the scope of this review, the reader is referred to some recently published work on this topic and the involvement in glaucoma pathogenesis. 1,33,[37][38][39][40] Therapeutic Strategies…”

Section: Pathophysiology Of Glaucomamentioning

confidence: 99%

Pharmacotherapy of Glaucoma

Schmidl

Schmetterer²,

Garhöfer³

et al. 2015

Journal of Ocular Pharmacology and Therapeutics

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127

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Glaucoma is a group of diseases involving the optic nerve and associated structures, which is characterized by progressive visual field loss and typical changes of the optic nerve head (ONH). The only known treatment of the disease is reduction of intraocular pressure (IOP), which has been shown to reduce glaucoma progression in a variety of large-scale clinical trials. Nowadays, a relatively wide array of topical antiglaucoma drugs is available, including prostaglandin analogues, carbonic anhydrase inhibitors, beta-receptor antagonists, adrenergic agonists, and parasympathomimetics. In clinical routine, this allows for individualized treatment taking risk factors, efficacy, and safety into account. A major challenge is related to adherence to therapy. Sustained release devices may help minimize this problem but are not yet available for clinical routine use. Another hope arises from non-IOP-related treatment concepts. In recent years, much knowledge has been gained regarding the molecular mechanisms that underlie the disease process in glaucoma. This also strengthens the hope that glaucoma therapy beyond IOP lowering will become available. Implementing this concept with clinical trials remains, however, a challenge.

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Section: Pathophysiology Of Glaucomamentioning

confidence: 99%

Pharmacotherapy of Glaucoma

Schmidl

Schmetterer²,

Garhöfer³

et al. 2015

Journal of Ocular Pharmacology and Therapeutics

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127

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“…Alterations in the retinal blood circulation were recently shown to be connected to the development of several serious eye diseases such as glaucoma, diabetic retinopathy and age related macular degeneration [1][2][3]. In the case of glaucomatous optic neuropathy (GON), two principal theories have been described [4].…”

Section: Introductionmentioning

confidence: 99%

Total retinal blood flow measurement by three beam Doppler optical coherence tomography

Haindl

Trasischker

Wartak

et al. 2016

Biomed. Opt. Express

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We present measurements of total retinal blood flow in healthy volunteers using a three beam Doppler optical coherence tomography (D-OCT) technique. This technology has the advantage of a precise determination of the flow vector without the use of any a-priori information on the vessel geometry. Circular D-OCT scans around the optic disc were recorded and venous as well as arterial total blood flow was determined and compared for each subject. The reproducibility of the method was assessed in 6 subjects by repeated measurements. Only small deviations of around 6% between the measurements were found which indicates the high precision of the proposed method. Werkmeister, "Blood flow velocity vector field reconstruction from dual-beam bidirectional Doppler OCT measurements in retinal veins," Biomed. Opt. Express 6(5), 1599-1615 (2015). 38. C. E. Riva, J. E. Grunwald, S. H. Sinclair, and B. L. Petrig, "Blood velocity and volumetric flow rate in human retinal vessels," Invest. Ophthalmol. Vis. Sci. 26(8), 1124-1132 (1985). 39. J. P. Garcia, Jr., P. T. Garcia, and R. B. Rosen, "Retinal blood flow in the normal human eye using the canon laser blood flowmeter," Ophthalmic Res. 34(5), 295-299 (2002

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“…In 2007, a first report of total retinal blood flow (TRBF) in one human subject was published, 2 soon to be followed by other groups reporting larger sample sizes and different approaches for measuring total blood flow. [3][4][5][6][7][8] So far several ocular diseases, such as age-related macular degeneration, 9,10 glaucoma, 11,12 and diabetic retinopathy, 10,13,14 were shown to be linked with early changes in choroidal and retinal perfusion. To assess ocular blood flow changes, it is of special interest to have a validated system available, which is easily applicable in routine future clinical practice.…”

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confidence: 99%

Total Retinal Blood Flow in a Nonhuman Primate Optic Nerve Transection Model Using Dual-Beam Bidirectional Doppler FD-OCT and Microsphere Method

Told

Wang

Cull

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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Citation: Told R, Wang L , Cull G, et al. Total retinal blood flow in a nonhuman primate optic nerve transection model using dual-beam bidirectional Doppler FD-OCT and microsphere method. Invest Ophthalmol Vis Sci. 2016;57:143257: -144057: . DOI:10.1167 PURPOSE. We validated noninvasive Doppler-optical coherence tomography (OCT) blood flow measurements against the terminal microsphere method in a surgical induced optic nerve transection nonhuman primate model. METHODS.In 6 nonhuman primates, total retinal blood flow (TRBF) was measured with a custom-built dual-beam bidirectional Doppler Fourier Domain (FD)-OCT. Peripapillary retinal nerve fiber layer thickness (RNFLT) was measured by Spectralis spectral-domain (SD)-OCT. Measurements were performed every 10 to 15 days before and after unilateral optic nerve transection (ONT) until RNFLT was reduced by more than 40% from baseline. Before the animals were killed, TRBF was measured using the microsphere technique. RESULTS.A significant correlation between all arterial and venous Doppler OCT TRBF measurements was found in ONT and contralateral control eyes (both P < 0.01, n ¼ 6). The Bland-Altman analysis showed a bias of 0.57 in the ONT group and 0.02 in the contralateral control group. Also, excellent agreement was observed between Doppler OCT and microsphere measurements (P < 0.01, r ¼ 0.976, bias ¼ 0.54). After ONT, TRBF and RNFLT decreased by À51% 6 42% and À44% 6 2% (n ¼ 5), respectively. In the contralateral control eyes, TRBF and RNFLT were unchanged.CONCLUSIONS. Very good accordance was found between TRBF measurements, obtained with dual-beam bidirectional Doppler FD-OCT and the microsphere method. It also was possible to monitor changes over time in TRBF after ONT with Doppler OCT. These findings highlight the accuracy and potential of noninvasive Doppler OCT to provide valuable information for detecting early changes in ocular disease in future.

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Ocular perfusion pressure in glaucoma

Cited by 195 publications

References 181 publications

Pharmacotherapy of Glaucoma

Pharmacotherapy of Glaucoma

Total retinal blood flow measurement by three beam Doppler optical coherence tomography

Total Retinal Blood Flow in a Nonhuman Primate Optic Nerve Transection Model Using Dual-Beam Bidirectional Doppler FD-OCT and Microsphere Method

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