Ocular Penetration of Topically Applied Gentamicin

Ellerhorst, Bernd; Golden, Bruce; Jarudi, Nabil

doi:10.1001/archopht.1975.01010020383014

Cited by 34 publications

(10 citation statements)

References 10 publications

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“…In contrast to results of previous studies (8,16), in this investigation, high levels of drug were achieved after one iontophoresis treatment. In all groups, a comparison of iontophoresis and the use of an eye cup without current showed that significantly higher levels (P = 0.0001) of tobramycin were achieved in the cornea when a current was passed through the solution.…”

Section: Discussioncontrasting

confidence: 99%

“…The incidence of ulcerative P. aeruginosa keratitis has steadily increased since the introduction of extended wear soft contact lenses (3,8,12). If not appropriately and promptly treated, P. aeruginosa keratitis can rapidly develop into a sight-threatening infection (1,17).…”

mentioning

confidence: 99%

“…Localized tissue trauma associated with infection and inflammation can alter the pharmacokinetics and increase the penetration of drugs used to treat ocular infections (5,8,11,16). No study to date has quantitated the effect of bacterial keratitis on the corneal penetration of tobramycin administered by iontophoresis.…”

mentioning

confidence: 99%

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Iontophoretic application of tobramycin to uninfected and Pseudomonas aeruginosa-infected rabbit corneas

Hobden

Rootman

O’Callaghan

et al. 1988

Antimicrob Agents Chemother

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Pseudomonas aeruginosa keratitis was induced in rabbits to study the effects of corneal infection on the delivery of tobramycin by iontophoresis. Some rabbits were treated by use of an eye cup with no current as a control for iontophoresis, and others were treated with fortified drops (1.36%) delivered topically for comparison with results of earlier studies. One hour after treatment with tobramycin, the concentration of drug in the infected corneas was compared with that achieved in mock-infected and uninfected eyes, lontophoresis of 25 mg of tobramycin per ml at 0.8 mA for 10 min delivered significantly more drug (P = 0.0001) to corneal tissue than did drops or use of an eye cup without current in P. aeruginosa-infected eyes, mock-infected eyes, or uninfected eyes. Tobramycin concentrations in the infected corneas (605.9 ,ug/g) were not significantly different (P 0.815) from the concentrations in mock-infected eyes (641.4 ,ug/g), but were lower (P = 0.007) than those obtained by iontophoresis in uninfected corneas (853.6 ,ug/g). Use of an eye cup without current delivered tobramycin equally to infected, mock-infected, and normal eyes, i.e., 176.5, 171.0, and 163.1 Lg/g, respectively (P > 0.709). Tobramycin delivered by use of fortified drops delivered topically was detectable in mock-infected corneas (20 Rg/g) and P. aeruginosa-infected corneas (6.0 ,ug/g). These results suggest that iontophoresis has value as an ocular drug delivery system and that an eye cup could also be useful in a therapeutic regimen for ocular infections.

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Section: Discussioncontrasting

confidence: 99%

mentioning

confidence: 99%

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Iontophoretic application of tobramycin to uninfected and Pseudomonas aeruginosa-infected rabbit corneas

Hobden

Rootman

O’Callaghan

et al. 1988

Antimicrob Agents Chemother

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“…Using this model, anti microbial substances such as ciprofloxacin, ofloxacin and gentamicin may be tested under standardized conditions. As amply emphasized in previous studies [8], the in flamed eye shows a higher uptake of gentamicin. Quite high levels of gentamicin could be obtained in seriously in flamed eyes by at least hourly application for prolonged pe riods.…”

Section: Discussionsupporting

confidence: 64%

Absorption of Topically Administered Ciprof loxacin. Of loxacin and Gentamicin in the Inflamed Rabbit Eye

Behrens–Baumann

1996

Ophthalmologica

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“…Among them, lornefloxacin (LFLX) has been demonstrated to be transferred into the aqueous humor of rabbits at a much higher concentration after instillation (Ooishi et al 1988) than any other antibiotic so far available (Barza et al 1973;Bloome et al 1970;Ellerforst et al 1975;Fukuda et al 1986;Iwata et al 1976;Kleinberg et aL 1979;Mercer et al 1978;Ooishi et al 1983Ooishi et al ,1987. Psewtmnonas aeruginosa is a major cause of endophthalmitis in Japan (Hatano et al 1991).…”

mentioning

confidence: 99%

Application of topical lomefloxacin against experimental Pseudomonas endophthalmitis in rabbits

Hatano

Inoue

Shiao

et al. 1993

Acta Ophthalmologica

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Lomefloxacin is a new quinolone compound with a broad antibacterial spectrum and excellent penetration into the aqueous humor by topical application. Therefore, an experimental study was done to evaluate the efficacy of topical lomefloxacin against experimental endophthalmitis with Pseudomrmas ""ginosa. Lomefloxacin eye drops wereinstilled six timesa day onto infected rabbit eyes and gentamicin, sulbenicillin and saline were also tested comparatively in the same manner as lomefloxacin. C h iral observation for 1 week and counting viable pseudomonas cell numbers in the anterior chamber were done. Among all topical eye drops tested, lomefloxacin was shown to he most effective in lowering clinical scores and viable cell numbers in the anterior chamber. In conclusion, lomefloxacin is expected to he a useful ophthalmicsolution i n the treatment of pseudomonal endophthalmitis

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Ocular Penetration of Topically Applied Gentamicin

Cited by 34 publications

References 10 publications

Iontophoretic application of tobramycin to uninfected and Pseudomonas aeruginosa-infected rabbit corneas

Iontophoretic application of tobramycin to uninfected and Pseudomonas aeruginosa-infected rabbit corneas

Absorption of Topically Administered Ciprof loxacin. Of loxacin and Gentamicin in the Inflamed Rabbit Eye

Application of topical lomefloxacin against experimental Pseudomonas endophthalmitis in rabbits

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