Ocular manifestations of emerging arboviruses: Dengue fever, Chikungunya, Zika virus, West Nile virus, and yellow fever

Merle, H.; Donnio, A; Jean-Charles, A; Guyomarch, J.; Hage, Rabih; Najioullah, Fatiha; Césaire, Raymond; Cabie, André

doi:10.1016/j.jfo.2018.05.002

Cited by 66 publications

(83 citation statements)

References 81 publications

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“…As an extension of the CNS, the eye displays similarities to the brain and spinal cord in terms of anatomy, functionality, response to injury, and inflammation [49]. Although eyes are sequestered from the systemic circulation, numerous viruses, among them arboviruses can still reach this organ and cause inflammation and pathologies [50]. Several flaviviruses, including DENV, ZIKV and WNV, have been described as triggering ophthalmic damage, including retinopathy [51].…”

Section: Usuv Induces Inflammatory Responses In the Eye And Efficientmentioning

confidence: 99%

“…It thus represents a powerful tool to study the pathophysiology of the RPE. Anatomically and developmentally, the eyes are known as an extension of the CNS and are proposed to act as a reservoir of viral replication; moreover RPE are known to be targeted by numerous pathogens including arboviruses, such as DENV, ZIKV and WNV, leading to major ophthalmological damage [50,51,56,76]. Numerous studies have shown the critical role of immune cells in retinal disease, and neuroinflammation is an important aspect of many diseases of the eye.…”

Section: Plos Neglected Tropical Diseasesmentioning

confidence: 99%

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Study of Usutu virus neuropathogenicity in mice and human cellular models

et al. 2020

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Usutu virus (USUV), an African mosquito-borne flavivirus closely related to West Nile virus, was first isolated in South Africa in 1959. USUV emerged in Europe two decades ago, causing notably massive mortality in Eurasian blackbirds. USUV is attracting increasing attention due to its potential for emergence and its rapid spread in Europe in recent years. Although mainly asymptomatic or responsible for mild clinical signs, USUV was recently described as being associated with neurological disorders in humans such as encephalitis and meningoencephalitis, highlighting the potential health threat posed by the virus. Despite this, USUV pathogenesis remains largely unexplored. The aim of this study was to evaluate USUV neuropathogenicity using in vivo and in vitro approaches. Our results indicate that USUV efficiently replicates in the murine central nervous system. Replication in the spinal cord and brain is associated with recruitment of inflammatory cells and the release of inflammatory molecules as well as induction of antiviral-responses without major modulation of bloodbrain barrier integrity. Endothelial cells integrity is also maintained in a human model of the blood-brain barrier despite USUV replication and release of pro-inflammatory cytokines. Furthermore, USUV-inoculated mice developed major ocular defects associated with inflammation. Moreover, USUV efficiently replicates in human retinal pigment epithelium. Our results will help to better characterize the physiopathology related to USUV infection in order to anticipate the potential threat of USUV emergence.

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Section: Usuv Induces Inflammatory Responses In the Eye And Efficientmentioning

confidence: 99%

Section: Plos Neglected Tropical Diseasesmentioning

confidence: 99%

Study of Usutu virus neuropathogenicity in mice and human cellular models

et al. 2020

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“…Several atypical or rare presentations of WNV infection such as cerebellitis, myocarditis, hepatitis, pancreatitis, and rhabdomyolysis have been described in case reports or small case series 1 . Although rare, ocular manifestations, including monofocal or multifocal WNV chorioretinitis are the most commonly reported clinical manifestations of WNV infection after fever and neuroinvasive disease [2][3][4][5] .…”

Section: Dear Editormentioning

confidence: 99%

West Nile virus retinitis in a patient with neuroinvasive disease

Konjevoda

Dželalija

Čanović

et al. 2019

Rev. Soc. Bras. Med. Trop.

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“…It usually manifests as a benign and self-limited viral disease characterized by the triad: sudden fever, arthralgia/arthritis, and rash 2 . Atypical manifestations have been described in the literature affecting different organs and systems such as neurological, ophthalmologic and dermatological manifestations which can be severe or debilitating [3][4][5][6] Children and the elderly appear to be more affected by atypical manifestations 7,8 .…”

Section: Introductionmentioning

confidence: 99%

Vesiculobullous exanthema in a 3-month-old child with probable acute chikungunya infection

Farias

Neto

Leite³

2019

J Health Biol Sci.

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Objetivo: relatar o caso raro de uma criança de 3 meses de idade com infecção aguda por chikungunya apresentando-se como erupção vesiculobolhosa. Descrição do caso: aqui relatamos o caso de uma criança de 3 meses que evoluiu com erupção eritematosa difusa envolvendo tronco e membros dois dias após febre aguda repentina, além de apresentar irritabilidade marcante com choro inconsolável, hiporexia, tosse e coriza. Investigações hematológicas e bioquímicas foram realizadas e foram normais. Amostras de soro foram testadas para Chikungunya revelando IgM positiva. Ele foi tratado com terapia de suporte, principalmente com antipiréticos, hidratação venosa e descanso evoluindo com resolução completa dos sintomas após quatro dias. Comentários: a febre Chikungunya é uma doença causada pelo vírus Chikungunya, que pode ser encontrada em áreas endêmicas como o Brasil. Manifestações atípicas podem afetar vários sistemas, incluindo a pele, e podem ser mais frequentes em crianças. O papel das manifestações dermatológicas relacionadas à infecção por Chikungunya não é completamente compreendido. O caso relatado é um caso incomum de infecção por Chikungunya, que destaca a importância de conhecer e ter consciência dessa manifestação em crianças, principalmente em novas áreas endêmicas como o Brasil.

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Ocular manifestations of emerging arboviruses: Dengue fever, Chikungunya, Zika virus, West Nile virus, and yellow fever

Cited by 66 publications

References 81 publications

Study of Usutu virus neuropathogenicity in mice and human cellular models

Study of Usutu virus neuropathogenicity in mice and human cellular models

West Nile virus retinitis in a patient with neuroinvasive disease

Vesiculobullous exanthema in a 3-month-old child with probable acute chikungunya infection

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