Ocular Manifestations of Diffuse Collagen Disease

Stillerman, Manuel L.

doi:10.1001/archopht.1951.01700010245001

Cited by 38 publications

(3 citation statements)

References 20 publications

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“…Inflammation can be due to minor trauma or 'allergic' factors causing a vascular insult, for example, erythema nodosum (Duke-Elder and Leigh, 1965). Episcleritis is also seen in the group of connective tissue diseases (Stillerman, 1951;Manschot, 1961), but among patients presenting with episcleritis the incidence of these diseases is low (Lyne and Pitkeathly, 1968). The uveal tract (composed of the iris, ciliary body, and choroid) is also highly vascular.…”

Section: Discussionmentioning

confidence: 99%

Scleritis and aortic incompetence. Two manifestations of connective tissue disease.

Pitkeathly¹,

Howitt²,

Lyne³

1970

Annals of the Rheumatic Diseases

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From the Departments of Rheumatism Research and Cardiology, Manchester Royal Infirmary, and the Manchester Royal Eye HospitalScleritis is known to occur as a manifestation of connective tissue disease, particularly rheumatoid arthritis and polyarteritis nodosa (Manschot, 1961).In a recent study of 31 patients with scleritis (Lyne and Pitkeathly, 1968), evidence of connective tissue disease was found in fourteen (45 per cent.). Since this study was completed, we have encountered a further three patients presenting with scleritis in whom aortic incompetence was found. Two had severe aortic regurgitation and complete atrioventricular (AV) block. The third had a diffuse arteritis, and the aortic incompetence was only a minor feature of this illness.Case reports Case 1, a 56-year-old housewife, gave a 5-year history of almost continuous inflammation affecting the left eye with severe pain at times. The right eye had never been involved. For 2 years she had complained of breathlessness, weakness, tiredness, and light-headedness on exertion. During the previous few months, she had experienced episodes of dizziness and had lost consciousness on several occasions. Examination The abnormalities were confined to the left eye and the cardiovascular system.The perilimbal sclera of the left eye showed diffuse thinning for about 2 mm. all round. The sclera elsewhere was thickened by a subconjunctival granulomatous-like infiltration. A fairly severe uveitis was present. There was elevation of the retina on the temporal side subjacent to the site of the most intense inflammation.The pulse was regular, collapsing in type, and the rate 38/min. The blood pressure was 220/40 mm. Hg. A hyperdynamic left ventricular impulse was palpable. There was a short aortic ejection systolic murmur and a moderately long aortic diastolic murmur. The aortic second sound was diminished.

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Section: Discussionmentioning

confidence: 99%

Scleritis and aortic incompetence. Two manifestations of connective tissue disease.

Pitkeathly¹,

Howitt²,

Lyne³

1970

Annals of the Rheumatic Diseases

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“…The ocular complications of SLE are most often seen in the posterior part of the eye and usually occur in more seriously ill patients with active systemic disease rather than in patients who have a milder form of the disease, or who are in remission [13][14][15],…”

Section: Discussionmentioning

confidence: 99%

Combined Arterial and Venous Retinal Occlusion as a Presenting Sign of Systemic Lupus erythematosus

et al. 1985

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“…21,22 Uveitic or non-uveitic ophthalmic findings have been reported in 30% to 50% of patients, with as high as 16% of patients manifesting varying forms of uveitis. 23,24 Iida et al reported a case of bilateral retinal arterial occlusion associated with choroidal occlusion, confirmed by ICG, in a patient with known WG. It was speculated that the retinal ischemia was probably due to retinal vasculitis leading to CRVO/BRVO.…”

Section: Retinal Vasculitismentioning

confidence: 97%