Ocular Manifestations of Allergic and Immunologic Diseases

Christensen, Logan; McDonnell, John T.; Singh, Jasleen

doi:10.1007/978-3-319-18389-3_3

Cited by 2 publications

(4 citation statements)

References 234 publications

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“…6 Signs and symptoms of SAC include redness, periocular itching, epiphora, burning, stinging, photophobia, watery discharge, and swollen or dry eyes, with differing degrees of severity and variable duration. 7,8 Since its discovery more than 50 years ago, immunoglobulin E (IgE) has been shown to be involved in a wide variety of immunological diseases, including allergic disease. [9][10][11] Despite being the least abundant immunoglobulin in normal human serum, IgE plays a key role in SAC.…”

Section: Introductionmentioning

confidence: 99%

“…SAC has a considerable impact on patients' quality of life and comfort, and results in a substantial burden on the economy through health care costs and the reduction in productivity 6 . Signs and symptoms of SAC include redness, periocular itching, epiphora, burning, stinging, photophobia, watery discharge, and swollen or dry eyes, with differing degrees of severity and variable duration 7,8 …”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Total IgE in tears accurately reflects the severity and predicts the prognosis of seasonal allergic conjunctivitis

Bao

Tian

Meng

et al. 2022

Clinical & Translational All

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Background Although immunoglobulin E (IgE) increases significantly in tears and serum during seasonal allergic conjunctivitis (SAC), it is unclear whether tear total IgE can reflect the severity and prognosis of SAC more accurately than serum total IgE. We aimed to investigate the usefulness of measuring the total IgE in tears to evaluate the severity and determine the treatment of SAC. Methods This prospective, nonrandomized study involved 55 patients with SAC and 10 age‐ and sex‐matched healthy controls. Serum and tears were collected before and after treatment to analyze the total IgE. SAC patients received the same topical anti‐allergy treatment and were followed‐up every 2 weeks for 1 month. The relationship of tear and serum total IgE concentrations with pollen concentrations and symptom severity before and after treatment was assessed. Results The total IgE concentration in tears was higher in SAC patients than in healthy participants with significant correlations between tear and serum total IgE concentrations. The total IgE concentration in tears, but not in serum, correlated with the pollen concentration and severity of ocular symptoms and reactions in SAC. Treatment‐associated improvements in symptoms and reactions in SAC correlated with decreased concentrations of the tear total IgE. Patients with disease recurrence following treatment demonstrated significantly higher tear total IgE concentrations than patients with no recurrence. Conclusion The total tear IgE level can indicate the severity and predict the prognosis of SAC more accurately than the serum total IgE.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Total IgE in tears accurately reflects the severity and predicts the prognosis of seasonal allergic conjunctivitis

Bao

Tian

Meng

et al. 2022

Clinical & Translational All

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“…Adapted from Bielory et al 125,126 Alternative manifestations described in patients with CVID include keratitis, uveitis with granulomatous inflammation, retinal vasculitis, choroiditis, bilateral optic neuritis and chorioretinitis. 127 Immunoglobulin A (IgA) deficiency is the most common PID, and most patients are asymptomatic. Despite this, there is an increased incidence of autoimmune diseases and recurrent respiratory and gastrointestinal infections.…”

Section: Figurementioning

confidence: 99%

Latin American Guideline on the Diagnosis and Treatment of Ocular Allergy - On behalf of the Latin American Society of Allergy, Asthma and Immunology (SLAAI)

Chong-Neto¹,

Cepeda²,

Moreira³

et al. 2022

AAAI

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A alergia ocular, também conhecida como conjuntivite alérgica (CA), é uma reação de hipersensibilidade mediada por imunoglobulina E (IgE) do olho desencadeada por aeroalérgenos, principalmente ácaros da poeira doméstica e pólen de gramíneas. Os sintomas geralmente consistem em prurido ocular ou periocular, lacrimejamento e olhos vermelhos que podem estar presentes durante todo o ano ou sazonalmente. A alergia ocular tem frequência elevada, é subdiagnosticada e pode ser debilitante para o paciente. É potencialmente danosa para a visão, nos casos em que ocasiona cicatrização corneana grave, e na maioria dos pacientes associa-se a outros quadros alérgicos, principalmente rinite, asma e dermatite atópica. É classificada em conjuntivite alérgica perene, conjuntivite alérgica sazonal, ceratoconjuntivite atópica e ceratoconjuntivite vernal. O diagnóstico procura evidenciar o agente etiológico e a confirmação se dá pela realização do teste de provocação conjuntival. O tratamento baseia-se em evitar o contato com os desencadeantes, lubrificação, anti-histamínicos tópicos, estabilizadores de mastócitos, imunossupressores e imunoterapia específica com o objetivo de obter o controle e prevenir as complicações da doença.Descritores: Alergia ocular, conjuntivite alérgica, rinoconjuntivite.Ocular allergy, also known as allergic conjunctivitis, is an immunoglobulin E-mediated hypersensitivity reaction of the eye triggered by airborne allergens, primarily house dust mites and grass pollen. Symptoms usually consist of ocular or periocular itching, watery eyes, and red eyes that may be present year-round or seasonally. Ocular allergy has a high frequency, is underdiagnosed, and can be debilitating for the patient. It is potentially harmful to vision in cases of severe corneal scarring, and in most patients, it is associated with other allergic conditions, especially rhinitis, asthma, and atopic dermatitis. It is classified as perennial allergic conjunctivitis, seasonal allergic conjunctivitis, atopic keratoconjunctivitis, and vernal keratoconjunctivitis. Diagnosis seeks to identify the etiologic agent, and confirmation is given by conjunctival provocation testing. Treatment is based on avoiding contact with triggers, lubrication, topical antihistamines, mast cell stabilizers, immunosuppressants, and specific immunotherapy with the aim of achieving control and preventing disease complications.

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Ocular Manifestations of Allergic and Immunologic Diseases

Cited by 2 publications

References 234 publications

Total IgE in tears accurately reflects the severity and predicts the prognosis of seasonal allergic conjunctivitis

Total IgE in tears accurately reflects the severity and predicts the prognosis of seasonal allergic conjunctivitis

Latin American Guideline on the Diagnosis and Treatment of Ocular Allergy - On behalf of the Latin American Society of Allergy, Asthma and Immunology (SLAAI)

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