Ocular manifestations in a community-based cohort of patients with inflammatory bowel disease

Cury, Dídia Bismara; Moss, Alan C.

doi:10.1002/ibd.21180

Cited by 43 publications

(43 citation statements)

References 18 publications

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“…This group also showed significantly lower tear production and tear quality (Schirmer-I test and TBUT test) in patients with UC compared with the controls. This is the first study of its kind to show compromises to the tear fluid and conjunctival cells in subjects with inflammatory bowel disease, further confirming the usefulness of IC in diagnosis and monitoring of systemic disease-associated dry eye [69].…”

Section: Colitis and Coeliac Diseasesupporting

confidence: 64%

“…UC is a chronic condition which manifests as colonic mucosal inflammation and ulceration. This disorder also presents with numerous ocular complications, including dry eye, blepharitis, episcleritis and anterior uveitis [69]. In this novel study, samples from patients with UC (n = 15) were compared with healthy controls (n = 15).…”

Section: Colitis and Coeliac Diseasementioning

confidence: 99%

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Biomarkers of Ocular Surface Disease Using Impression Cytology

Hagan

2017

Biomark. Med.

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Impression cytology (IC) is a technique which permits the retrieval of the outermost layer of ocular surface cells via the use of various types of filters. It is a minimally invasive method of evaluating human conjunctival epithelial cell morphology in the diagnosis of dry eye disease, a common and distressing disorder associated with ageing, contact lens wear, autoimmune disorders and refractive (LASIK) surgery. IC may also be utilized in the diagnosis of other ocular diseases, such as keratoconus and thyroid orbitopathy. More recently, IC has been utilized for the subsequent investigation of gene and protein expression of conjunctival cells in order to identify novel diagnostic biomarkers and to further our understanding of the mechanisms underlying ocular surface disease. This review will therefore examine the literature concerning the role of IC in identifying cellular markers of eye disease, systemic diseases with ocular involvement and potential novel therapeutic targets. Impression cytology (IC) is a minimally invasive method of evaluating human ocular surface cells and is considered as the 'gold standard' technique for assessing cell morphology. Introduced by Thatcher et al. [1] and Egbert et al. [2], IC is an easy-to-use technique of directly retrieving (mainly conjunctival) cells, using various filter types which are gently applied to exposed (interpalpebral) conjunctival surfaces. The filters used include cellulose acetate [3], polycarbonate (Biopore, Millipore UK Ltd, Watford, UK) [4], nitrocellulose [5] or polyethersulfone (PES) [6] which are gently applied to exposed (interpalpebral) conjunctival surfaces. Recently, a more standardized tool for IC sampling has been introduced (Figures 1 & 2). The Eyeprim is a new single-use PES filter sampling medical device for retrieval of conjunctival cells (Opia Technologies, France) and a recent study by Lopez-Miguel et al. [7] performed an analysis of this tool versus the traditional IC method (PES). On a cohort of 20 healthy individuals, they extracted and compared RNA from both devices and found no significant differences in the mean yield (p ≥ 0.45), the total RNA amount (μg), or the amount normalized to membrane area [7]. Although an earlier study of the Eyeprim [8], suggested that it recovered more cells than traditional IC, Lopez-Miguel et al. [7] did not observe differences in the RNA collected between this device and PES.Historically, IC has been used to analyze pathological changes to conjunctival cells for indicators of squamous metaplasia in ocular surface disease (OSD) [9]. More recently, however, researchers have used IC to examine specific markers of inflammation, for example, HLA-DR, ICAM-1 and CD8 [10][11][12], and to examine novel biomarkers of dry eye disease (DED). The latter is performed in an attempt to understand the mechanisms underpinning DED pathophysiology and is now feasible, due to vast improvements in the assay sensitivities for gene and protein examination [13]. As a result, IC membranes can be subsequently analyzed using techniq...

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Section: Colitis and Coeliac Diseasesupporting

confidence: 64%

Section: Colitis and Coeliac Diseasementioning

confidence: 99%

Biomarkers of Ocular Surface Disease Using Impression Cytology

Hagan

2017

Biomark. Med.

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“…Recently, dry eye has been evidenced to be frequent during the course of the disease. 4 Most patients already have a diagnosed IBD before occurrence of ocular signs. 3 However, in some cases ocular manifestations may occur before the diagnosis of IBD and reveal the disease.…”

Section: To the Editormentioning

confidence: 99%

Infliximab for severe peripheral ulcerative keratopathy revealing Crohnʼs disease

Angioï¹,

Kaminsky²,

Peyrin–Biroulet³

2011

Inflammatory Bowel Diseases

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“…The prevalence of dry eye has been reported in up to 40% of IBD patients [4,19]. The etiology of the high prevalence of dry eye symptoms in this population is unclear.…”

Section: Treatment-related Pathologiesmentioning

confidence: 99%

“…The use of 5-aminosalicylic acid medications was strongly associated with dry eyes, particularly in doses >3 g per day [19]. …”

Section: Treatment-related Pathologiesmentioning

confidence: 99%

Managing IBD Outside the Gut: Ocular Manifestations

Calvo

Júlvez

2013

Dig Dis

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Extraintestinal manifestations are common in inflammatory bowel disease (IBD), being reported in over 25% of patients. Ocular complications of IBD occur in around 10% of cases, but may precede systemic symptoms and are usually nonspecific. Complications of therapy, such as cataracts or glaucoma from steroid use or keratoconjunctivitis sicca related to 5-aminosalicylic acid medications, may also involve the eyes. The pathogenesis remains unclear, but factors such as the extent of intestinal disease, disease activity, and the presence of associated arthritis have been associated with ocular involvement. Conjunctivitis, episcleritis, scleritis and uveitis are by far the most common ophthalmic complications of IBD. However, posterior uveitis, intraretinal hemorrhages, vasculitis, choroiditis, optic neuropathy, and vaso-occlusive phenomena may also occur. The most frequent severe ocular manifestation is anterior uveitis (more common in women). It usually presents as a mild anterior nongranulomatous uveitis (60% of the cases). The inflammation in the eye and the inflammation in the gut are rarely correlated. Patients with uveitis, scleritis, and other anterior segment inflammation usually respond to steroids (topical, periocular or systemic). If the inflammation is resistant to steroids, or if appreciable steroid adverse effects are encountered, systemic immunosuppressive treatment should be considered; this is more likely in HLA-B27-positive patients with uveitis. Evaluation of the eye should be a routine component in the care of patients with IBD.

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Ocular manifestations in a community-based cohort of patients with inflammatory bowel disease

Abstract: Patients with IBD in the community frequently have dry eyes. This is associated with 5-ASA use, particularly doses >3 g per day. Whether this is a surrogate marker of disease severity is unclear.

Cited by 43 publications

References 18 publications

Biomarkers of Ocular Surface Disease Using Impression Cytology

Biomarkers of Ocular Surface Disease Using Impression Cytology

Infliximab for severe peripheral ulcerative keratopathy revealing Crohnʼs disease

Managing IBD Outside the Gut: Ocular Manifestations

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