Infliximab for severe peripheral ulcerative keratopathy revealing Crohnʼs disease

Angioï, K.; Kaminsky, P.; Peyrin–Biroulet, Laurent

doi:10.1002/ibd.21358

Cited by 7 publications

(8 citation statements)

References 6 publications

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“…There was no evidence of any autoimmune conditions associated with PUK, with the exception of Case 3 with Crohn disease, which has been associated with PUK. [11][12][13] In this patient, we cannot exclude that the keratitis could have been secondary to inflammatory bowel disease rather than to the previous alkali injury. The patient was older than the other cases but shared a similar long interval between the chemical injury and the onset of PUK.…”

Section: In This Case Series We Present 5 Cases Of Puk Withmentioning

confidence: 76%

“…PUK in Crohn disease usually accompanies reactivations of the intestinal inflammation; in our patient the keratitis occurred when the bowel disease was quiescent, which was the situation throughout the course of the ocular disease. [11][12][13] Two cases of PUK have been previously reported after mechanical ocular trauma. A case of peripheral ulcerative keratitis with necrotizing scleritis was described 1 month after surgical repair for a traumatic scleral rupture.…”

Section: In This Case Series We Present 5 Cases Of Puk Withmentioning

confidence: 96%

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Late-onset Peripheral Ulcerative Sclerokeratitis Associated With Alkali Chemical Burn

Iovieno¹,

Anand²,

Dart³

2014

American Journal of Ophthalmology

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Section: In This Case Series We Present 5 Cases Of Puk Withmentioning

confidence: 76%

Section: In This Case Series We Present 5 Cases Of Puk Withmentioning

confidence: 96%

Late-onset Peripheral Ulcerative Sclerokeratitis Associated With Alkali Chemical Burn

Iovieno¹,

Anand²,

Dart³

2014

American Journal of Ophthalmology

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“…30 Ocular involvement includes mainly episcleritis and uveitis, with PUK as a rare association. 29,30,31,32,33 Peripheral ulcerative keratitis in IBD can be the presenting feature of IBD or presents after previously diagnosed disease. 29,30,31,32,33 It affects men and women equally, favouring a younger onset from 33 years to 55 years.…”

Section: Inflammatory Bowel Diseasementioning

confidence: 99%

“…29,30,31,32,33 Peripheral ulcerative keratitis in IBD can be the presenting feature of IBD or presents after previously diagnosed disease. 29,30,31,32,33 It affects men and women equally, favouring a younger onset from 33 years to 55 years. 29,30,31,32,33 This cohort of patients have a more severe form of PUK, with most needing escalation of immunosuppressive therapy to biological agents in order to achieve disease control.…”

Section: Inflammatory Bowel Diseasementioning

confidence: 99%

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Peripheral ulcerative keratitis: A review of aetiology and management

Hӧllhumer

2022

African Vision and Eye Health

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Background: Peripheral ulcerative keratitis (PUK) is a severe inflammatory disease of the peripheral cornea that can be caused by local factors or systemic inflammatory disease.Aim: The purpose of this review is to give an overview of the pathophysiology, aetiology, clinical features, diagnosis, and management of PUK.Method: A PubMed search was conducted using the keywords, ‘peripheral ulcerative keratitis’ and ‘Mooren’s ulcer’.Results: The peripheral cornea has unique characteristics the predispose to the development of PUK. These include fine capillary arcades that allow for deposition of immune complexes and subsequent activation of an inflammatory cascade with corneal melt. Several conditions have been implicated in the aetiology of PUK. The most commonly cited causes are rheumatoid arthritis (RA), granulomatosis with polyangiitis (GPA) and various dermatoses. In patients with RA, PUK usually presents in established disease, whereas in GPA, PUK may be the presenting feature in up to 60% of cases. In RA it heralds the onset of a systemic vasculitis with significant associated morbidity and mortality. The management of PUK follows an individualised stepwise approach. All patients require supportive measures to encourage healing and halt the process of keratolysis. Systemic autoimmune conditions need a systemic corticosteroid as a fast-acting agent to halt the inflammatory process while cytotoxic therapy maintains long term disease control. Failure to achieve disease control with CTT, necessitates the use of a biologic agent.Conclusion: Peripheral ulcerative keratitis is a severe inflammatory disease of the peripheral cornea that needs a thorough diagnostic workup and stepwise management approach.

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Noninfectious Causes

Chow¹,

deLuise²

2017

Essentials in Ophthalmology

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Infliximab for severe peripheral ulcerative keratopathy revealing Crohnʼs disease

Cited by 7 publications

References 6 publications

Late-onset Peripheral Ulcerative Sclerokeratitis Associated With Alkali Chemical Burn

Late-onset Peripheral Ulcerative Sclerokeratitis Associated With Alkali Chemical Burn

Peripheral ulcerative keratitis: A review of aetiology and management

Noninfectious Causes

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