Ocular Human Papillomavirus Infections

Hanbazazh, Mehenaz; Gyure, Kymberly A.

doi:10.5858/arpa.2017-0571-ra

Cited by 20 publications

(28 citation statements)

References 58 publications

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“…Detection of HPV DNA in pterygia in some studies may have been due to contaminated samples. Sonnex et al reported that HPV from genitalia was transmitted via finger-genital contact 9 , and many studies have mentioned this mechanism of autoinoculation between HPV in the genital area and ocular surfaces, including pterygia 3,22,[24][25][26] . However, in this study, HPV in the genital tract was not associated with HPV-infected conjunctiva or pterygia.…”

Section: Discussionmentioning

confidence: 99%

Lack of HPV in pterygium with no evidence of autoinoculation and the role of cytokines in pterygium with dry eye

Uthaithammarat

Kasetsuwan

Chongpison

et al. 2021

Sci Rep

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This study evaluated human papillomavirus’s (HPV) role in pterygium pathogenesis, its autoinoculation from genitalia to ocular surface, potential cytokines involved, and crosstalk cytokines between pterygium and dry eye (DE). This cross-sectional study enrolled 25 healthy controls (HCs) and 116 pterygium patients. Four subgroups of pterygium and DE were used in cytokine evaluations. Conjunctival and pterygium swabs and first-void urine samples (i.e., genitalia samples) were collected for HPV DNA detection using real-time polymerase chain reaction. Tear cytokines interleukin (IL)-6, IL-18, and vascular endothelial growth factor (VEGF) in tears were evaluated. No HPV DNA was detected in conjunctival or pterygium swabs. No association was found between HPV DNA in urine samples and that from conjunctival or pterygium swabs. Tear VEGF levels were significantly higher in pterygium patients than in HCs, with no markedly different levels between primary and recurrent pterygia. Tear IL-6, IL-18, and tear VEGF were significantly higher in participants with DE, regardless of pterygium status. In conclusion, HPV infection was not a pathogenic factor of pterygia. The hypothesis of HPV transmitting from the genitals to ocular surfaces was nullified. Tear VEGF was involved in both pterygia and DE, whereas tear IL-6 and IL-18 played roles only in DE.

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Section: Discussionmentioning

confidence: 99%

Lack of HPV in pterygium with no evidence of autoinoculation and the role of cytokines in pterygium with dry eye

Uthaithammarat

Kasetsuwan

Chongpison

et al. 2021

Sci Rep

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“…HPV has already been implicated as a promotor of the development of both benign and malignant sebaceous tumors [31,32]. Squamous dysplasia of the conjunctiva and the lacrimal sac has also been shown to be associated with HPV [33,34]. DNA MMR nuclear protein expression was intact in the tumor cells for MSH6, MSH2, MLH1, and PMS2, thereby failing to implicate the Muir-Torre syndrome [35][36][37][38][39].…”

Section: Discussionmentioning

confidence: 99%

Villous Sebaceous Adenoma Arising from the Caruncular Surface Squamous Epithelium

Barrantes

Milman

2020

Ocul Oncol Pathol

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• Benign and malignant sebaceous cell tumors are both known to originate in the caruncle. • These tumors typically grow in nests and lobules in the caruncular stroma. • Sebaceous tumors arising from the surface non-keratinizing squamous epithelium of the epibulbar and tarsal regions have been reported. Novel Insights • A caruncular sebaceous adenoma originated from the surface squamous epithelium which displayed focal sebaceous cell differentiation. • The pattern of growth was most unusual and consisted of multiple invaginated crypts with intervening finger-like villi. • Lateral lobular sebaceous lobules originated as outgrowths from the crypts and were mostly responsible for the widening of the stroma between the crypts. • p16 nuclear and cytoplasmic positivity indicated a possible causative role for high-risk human papilloma virus, while immunohistochemical results for intact mismatch nuclear repair proteins ruled out an association with the Muir-Torre syndrome.

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“…Ätiologie Am häufigsten ist die CIN an der bulbären Bindehaut zu sehen, passend zu der Tatsache, dass UV-Strahlung den pathogenetischen Hauptfaktor darstellt. HPV scheint neben UV-Strahlung in manchen Fällen ein pathogenetischer Ko-Faktor zu sein [23,24], der Zusammenhang wird aber im Gegensatz zu dem Pendant der Zervix kontrovers diskutiert.…”

Section: Konjunktivale Intraepitheliale Neoplasie (Cin)unclassified

Bindehautdegenerationen und -neoplasien

Auw-Hädrich¹,

Gasser²,

Reinhard³

2022

Klin Monbl Augenheilkd

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ZusammenfassungErhabenheiten der Bindehaut entstehen durch Gewebevermehrung, die entweder degenerativ oder neoplastisch, aber auch entzündlich sein können. In diesem Artikel werden degenerative (Pterygium und Pinguecula) sowie benigne und maligne neoplastische Bindehautveränderungen (epitheliale, melanozytäre und vaskuläre Tumoren, Choristome sowie Metastasen) bezüglich der Pathogenese, Symptome, Diagnostik und aktuellem Stand der Behandlung dargestellt.

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Ocular Human Papillomavirus Infections

Cited by 20 publications

References 58 publications

Lack of HPV in pterygium with no evidence of autoinoculation and the role of cytokines in pterygium with dry eye

Lack of HPV in pterygium with no evidence of autoinoculation and the role of cytokines in pterygium with dry eye

Villous Sebaceous Adenoma Arising from the Caruncular Surface Squamous Epithelium

Bindehautdegenerationen und -neoplasien

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