Ocular Dipping in Creutzfeldt-Jakob Disease

Jeong, Seong-Hae; Kim, SangYun; Park, Seong-Ho; Kim, Ji Soo

doi:10.1097/wno.0b013e31818e4023

Cited by 6 publications

(7 citation statements)

References 17 publications

(22 reference statements)

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“…This phenomenon has been previously described in patients with OD and CJD, suggesting a complete loss of upward saccades that may be indicative of progression of the disease 11. Other disorders of involuntary eye movements in CJD include periodic alternating, upbeat, centripetal, and rebound nystagmus 11. Patients with CJD may also develop supranuclear vertical gaze palsy, slow vertical saccades, and skew deviation 4.…”

Section: Discussionmentioning

confidence: 60%

“…OD lasted for several days in the present case before changing into downward gaze deviation. This phenomenon has been previously described in patients with OD and CJD, suggesting a complete loss of upward saccades that may be indicative of progression of the disease 11. Other disorders of involuntary eye movements in CJD include periodic alternating, upbeat, centripetal, and rebound nystagmus 11.…”

Section: Discussionmentioning

confidence: 61%

“…OD was initially described following anoxic brain damage, but other etiologies have also been reported (Table 1). Three cases of OD in CJD have been reported that showed similar evolutions of this eye-movement disorder 11,12. OD lasted for several days in the present case before changing into downward gaze deviation.…”

Section: Discussionmentioning

confidence: 91%

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Ocular Dipping in Creutzfeldt-Jakob Disease

et al. 2014

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BackgroundOcular dipping (OD), or inverse ocular bobbing, consists of slow, spontaneous downward eye movements with rapid return to the primary position. It has been mainly reported following hypoxic-ischemic encephalopathy, but has also been described in association with other types of diffuse or multifocal encephalopathies and structural brainstem damage.Case ReportWe report the case of a previously asymptomatic 66-year-old woman who presented with confusion, recent memory disturbances, and abnormal involuntary movements, followed by a coma. Abnormal spontaneous vertical eye movements consistent with OD developed from the fourth day after admission, and the patient died 20 days later. The pathological examination of the brain confirmed the diagnosis of Creutzfeldt-Jakob disease.ConclusionsThe precise location of damage causing OD is unknown. In contrast to ocular bobbing, OD has no localizing value itself, but structural brainstem damage is likely when it appears combined with other spontaneous vertical eye movements.

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Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 61%

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Ocular Dipping in Creutzfeldt-Jakob Disease

et al. 2014

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“…7 Patients presenting with upbeat and GEN eventually show ocular dipping. 8 These abnormal eye findings point to central pathology involving the vestibulocerebellum and brainstem, and would be a useful diagnostic clue especially to an ataxic-cerebellar form of CJD.…”

Section: Discussionmentioning

confidence: 94%

Creutzfeldt–Jakob Disease Presenting With Dizziness and Gaze-Evoked Nystagmus

Choi

Kang

Lee³

et al. 2016

Medicine

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“…128,130 Although not commonly reported, ocular dipping can also be a characteristic ocular abnormality. 131,132 Disordered fixation with saccadic intrusions in the setting of severe insomnia can be a useful early diagnostic clue of FFI. 133 Gerstmann-Sträussler-Scheinker disease also presents with abnormal eye movements in the early stages such as pathologic nystagmus, impaired visual tracking, impaired VOR, and gaze-evoked nystagmus.…”

Section: Prion Diseasementioning

confidence: 99%

Eye Movement Disorders in Movement Disorders

Kassavetis

Kaski

Anderson

et al. 2022

Movement Disord Clin Pract

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Oculomotor assessment is an essential element of the neurological clinical examination and is particularly important when evaluating patients with movements disorders. Most of the brain is involved in oculomotor control, and thus many neurological conditions present with oculomotor abnormalities. Each of the different classes of eye movements and their features can provide important information that can facilitate differential diagnosis. This educational review presents a clinical approach to eye movement abnormalities that are commonly seen in parkinsonism, ataxia, dystonia, myoclonus, tremor, and chorea. In parkinsonism, subtle signs such as prominent square wave jerks, impaired vertical optokinetic nystagmus, and/or the “round the houses” sign suggest early progressive supranuclear gaze palsy before vertical gaze is restricted. In ataxia, nystagmus is common, but other findings such as oculomotor apraxia, supranuclear gaze palsy, impaired fixation, or saccadic pursuit can contribute to diagnoses such as ataxia with oculomotor apraxia, Niemann‐Pick type C, or ataxia telangiectasia. Opsoclonus myoclonus and oculopalatal myoclonus present with characteristic phenomenology and are usually easy to identify. The oculomotor exam is usually unremarkable in isolated dystonia, but oculogyric crisis is a medical emergency and should be recognized and treated in a timely manner. Gaze impersistence in a patient with chorea suggests Huntington's disease, but in a patient with dystonia or tremor, Wilson's disease is more likely. Finally, functional eye movements can reinforce the clinical impression of a functional movement disorder.

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Ocular Dipping in Creutzfeldt-Jakob Disease

Cited by 6 publications

References 17 publications

Ocular Dipping in Creutzfeldt-Jakob Disease

Ocular Dipping in Creutzfeldt-Jakob Disease

Creutzfeldt–Jakob Disease Presenting With Dizziness and Gaze-Evoked Nystagmus

Eye Movement Disorders in Movement Disorders

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