Ocular delivery of felodipine for the management of intraocular pressure and inflammation: Effect of film plasticizer and in vitro in vivo evaluation

Swain, Rakesh; Moharana, Ankita; Habibullah, Sk; Nandi, Souvik; Bose, Anindya; Mohapatra, Sujata; Mallick, Subrata

doi:10.1016/j.ijpharm.2023.123153

Cited by 3 publications

(1 citation statement)

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“…This is required for enhancing the outcomes of several medical procedures; e.g., buccal local anesthesia [11,12] Likewise, hydrophobic plasticizers can be used in the formulation of monolithic films intended to provide a sustained drug release profile for a long time span, such as in vaginal and ocular administration. Acetate esters such as glyceryl triacetate (triacetin), triethyl citrate, and acetyl triethyl citrate; phthalate esters (e.g., diethyl phthalate and dibutylphthalate); and acetylated monoglycerides are widely used for these purposes [29][30][31][32].…”

Section: Plasticizersmentioning

confidence: 99%

The Potential of Films as Transmucosal Drug Delivery Systems

de Carvalho,

Paiva,

Demonari

et al. 2023

Pharmaceutics

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Pharmaceutical films are polymeric formulations used as a delivery platform for administration of small and macromolecular drugs for local or systemic action. They can be produced by using synthetic, semi-synthetic, or natural polymers through solvent casting, electrospinning, hot-melt extrusion, and 3D printing methods, and depending on the components and the manufacturing methods used, the films allow the modulation of drug release. Moreover, they have advantages that have drawn interest in the development and evaluation of film application on the buccal, nasal, vaginal, and ocular mucosa. This review aims to provide an overview of and critically discuss the use of films as transmucosal drug delivery systems. For this, aspects such as the composition of these formulations, the theories of mucoadhesion, and the methods of production were deeply considered, and an analysis of the main transmucosal pathways for which there are examples of developed films was conducted. All of this allowed us to point out the most relevant characteristics and opportunities that deserve to be taken into account in the use of films as transmucosal drug delivery systems.

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