The Potential of Films as Transmucosal Drug Delivery Systems

de Carvalho, Ana Clara Wada; Paiva, Natália Floriano; Demonari, Isabella Kriunas; Duarte, Maíra Peres Ferreira; do Couto, Renê Oliveira; de Freitas, Osvaldo; Vicentini, Fabiana Testa Moura de Carvalho

doi:10.3390/pharmaceutics15112583

Cited by 5 publications

(1 citation statement)

References 141 publications

(253 reference statements)

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“…An application in dentistry of fast-dissolving films is the obtaining of sux formulations containing chlorhexidine by the solvent casting method. After in vitro decay analyses, antimicrobial activity tracking and stability studies, as well as using infrared spectroscopy with Fourier modifications, it was concluded that chlorhexidine films offer promising results in the management of oral diseases [64][65][66][67].…”

Section: Fast-dissolving Oral Films (Fdof)mentioning

confidence: 99%

Challenges in Optimizing Nanoplatforms Used for Local and Systemic Delivery in the Oral Cavity

Cocoș,

Dumitriu Buzia,

Tatu

et al. 2024

Pharmaceutics

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In this study, we focused on innovative approaches to improve drug administration in oral pathology, especially by transmucosal and transdermal pathways. These improvements refer to the type of microneedles used (proposing needles in the saw), to the use of certain enhancers such as essential oils (which, besides the amplifier action, also have intrinsic actions on oral health), to associations of active substances with synergistic action, as well as the use of copolymeric membranes, cemented directly on the tooth. We also propose a review of the principles of release at the level of the oral mucosa and of the main release systems used in oral pathology. Controlled failure systems applicable in oral pathology include the following: fast dissolving films, mucoadhesive tablets, hydrogels, intraoral mucoadhesive films, composite wafers, and smart drugs. The novelty elements brought by this paper refer to the possibilities of optimizing the localized drug delivery system in osteoarthritis of the temporomandibular joint, neuropathic pain, oral cancer, periodontitis, and pericoronitis, as well as in maintaining oral health. We would like to mention the possibility of incorporating natural products into the controlled failure systems used in oral pathology, paying special attention to essential oils.

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Section: Fast-dissolving Oral Films (Fdof)mentioning

confidence: 99%

Challenges in Optimizing Nanoplatforms Used for Local and Systemic Delivery in the Oral Cavity

Cocoș,

Dumitriu Buzia,

Tatu

et al. 2024

Pharmaceutics

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Novel Functional Dressing Materials for Intraoral Wound Care

Ding,

Zhu,

Zhang

et al. 2024

Adv Healthcare Materials

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Intraoral wounds represent a particularly challenging category of mucosal and hard tissue injuries, characterized by the unique structures, complex environment, and distinctive healing processes within the oral cavity. They have a common occurrence yet frequently inflict significant inconvenience and pain on patients, causing a serious decline in the quality of life. A variety of novel functional dressings specifically designed for the moist and dynamic oral environment have been developed and realized accelerated and improved wound healing. Thoroughly analyzing and summarizing these materials is of paramount importance in enhancing our understanding and proficiently managing intraoral wounds. In this review, the particular processes and unique characteristics of intraoral wound healing are firstly described. Up‐to‐date knowledge of various forms, properties and applications of existing products are then intensively discussed, which are categorized into animal products, plant extracts, natural polymers, and synthetic products. To conclude, this review presents a comprehensive framework of currently available functional intraoral wound dressings, with an aim to provoke inspiration of future studies to design more convenient and versatile materials.This article is protected by copyright. All rights reserved

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