Ocular chlamydial infections. Clinicomicrobiological correlation

Sk, Rao; Hn, Madhavan; Padmanabhan, P; Lakshmi, GS; Natarajan, K; Garg, Devanshu

doi:10.1016/s0002-9394(14)70462-3

Cited by 4 publications

(4 citation statements)

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“…[49] From 1990 to 1998, in 1061 conjunctivitis patients attending a Chennai eye hospital, 20.9% had laboratory evidence of C. trachomatis infections. [50] In 2002, same laboratory reported only 16 (4.9%) of 328 conjunctivitis patients were C. trachomatis positive by polymerase chain reaction (PCR) assay.…”

Section: Chlamydial Infections In Hospital Attendeesmentioning

confidence: 99%

Chlamydial eye infections: Current perspectives

Satpathy

Behera

Ahmed

2017

Indian J Ophthalmol

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Chlamydia trachomatis, an obligate intraocular bacteria causing trachoma, adult and neonatal inclusion conjunctivitis, was the leading cause of blindness in the last century worldwide. Improvement in socioeconomic and living conditions, availability of antibiotics, and introduction of National Trachoma Control Programmes reduced the prevalence in developed countries, but it persisted in resource-poor settings of Africa and Asia, including India. In 2016, as per the WHO report, trachoma is restricted to 42 countries, causing blindness/visual impairment in ~1.9 million people. India is one of the five countries with nearly half of total active trachoma patients. Introduction of Global Elimination of Trachoma 2020 program by the WHO, using SAFE strategy (surgery for trachomatous trichiasis; Antibiotics for C. trachomatis; Facial cleanliness; and environmental improvement) greatly reduced the prevalence, but trachoma still persists in India. Global increase in the reproductive tract infection by C. trachomatis urogenital serotypes (D-K) has led to concurrent increase in C. trachomatis eye infections. Therefore, kerato eye infections due to chlamydial infections continue to be seen in hospitals. Over the years, there have been advances in laboratory diagnostics, in understanding the pathogenesis, tissue tropism, C. trachomatis genomics, and treatment modalities. Due attention and research is still needed for the study of C. trachomatis eye infections.

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Section: Chlamydial Infections In Hospital Attendeesmentioning

confidence: 99%

Chlamydial eye infections: Current perspectives

Satpathy

Behera

Ahmed

2017

Indian J Ophthalmol

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“…Objektyvaus tyrimo metu randamos tąsios, gleivingos išskyros, nedidelis vokų bei junginių paburkimas, folikulinė ar papiliarinė reakcija [8]. Ragenoje gali atsirasti paviršinių epitelinių arba pakraštinių subepitelinių infiltratų, įaugti paviršinės kraujagyslės, dažniausiai viršu-tinėje dalyje [9].…”

Section: Aptarimasunclassified

Lėtinis Chlamidinis Konjunktyvitas: Atvejo Pristatymas

Šiaudvytytė

Barzdžiukas

Boguševičienė

et al. 2014

Medicinos Teorija Ir Praktika

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santrauKaReikšminiai žodžiai: lėtinis konjunktyvitas, chlamydia trachomatis, doksiciklinas. Konjunktyvitas -akies junginės uždegimas, kuris, užsitęsęs ilgiau kaip 3 savaites, tampa lėtine liga. Jauni, seksualiai aktyvūs žmonės dažniausiai užsikrečia chlamidiniu konjunktyvitu, iš jų 50 proc. kartu serga ir lytine liga (gimdos kaklelio uždegimu, uretritu). Nustatyta, kad 1 iš 15 seksualiai aktyvių 14-19 metų merginų yra užsikrėtusios chlamidijomis. Paplitimas tarp 14-24 metų asmenų yra 3 kartus didesnis nei tarp 25-39 metų asmenų. Šiame straipsnyje pristatomas lėtinio chlamidinio konjunktyvito atvejis: 31 metų buvusiam sveikam vyrui pasireiškė konjunktyvito požymiai. Laiku nenustačius etiologijos (chlamidinis konjunktyvitas) ir nepaskyrus tinkamo gydymo, konjunktyvitas tapo lėtinis, sutrikdęs regos aštrumą, sukėlęs ragenos infiltraciją (keratitą) bei paviršinę vaskuliarizaciją. aBstraCt Key words: chronic conjunctivitis, chlamydia trachomatis, doxycycline. Conjuntivitis -an inflammation of the conjuntiva, that becomes chronic if persists more than 3 weeks. Chlamydial conjuntivitis occurs most commonly in sexually active young adults, 50 % of them also have genital infection (cervicitis, urethritis). It is estimated that 1 from 15 sexually active young girl aged 14-24 years has chlamydial infection. Prevalence among sexually active persons aged 14-24 years is nearly three times higher than among those aged 25-39 years. In this article we present a clinical case of chronic chlamydial conjuntivitis: 31 years-old healthy male presented with symptoms of conjunctivitis. Conjuntivitis became chronic due to overdue of causative agent establishment and well-chosen treatment, therefore caused decrease in visual acuity, corneal infiltration (keratitis) and superficial corneal vascularisation. Lina Šiaudvytytė Lietuvos sveikatos mokslų universiteto Medicinos akademijos Akių ligų klinika Eivenių g. 2, Kaunas lynciuke@gmail.com ĮVADASKonjunktyvitas -akies junginės uždegimas, dažniausia "raudonos akies" sindromo priežastis. Junginė yra gleivinė, dengianti vokų vidinį paviršių ir priekinę akies obuolio dalį. Junginė gamina ašaras bei muciną, būtinus ašarų plėvelei susidaryti bei ragenos optinėms savybėms palaikyti. Be to, ji atlieka mechaninę bei antimikrobinę-barjerinę apsauginę funkciją [1]. Konjunktyvitu žmogus suserga tada, kai sutrinka pusiausvyra tarp normalios junginės floros ir patogeninių mikroorganizmų. Dėl vokų pažeidimo ar akies paviršiaus traumos sutrinka patogeninių mikroorganizmų nuo akies paviršiaus pašalinimas. Pusiausvyrą gali sutrikdyti ir ląsteli-nio bei humoralinio imuniteto sutrikimas, kurį gali įtakoti vyresnis amžius, alkoholis, žmogaus imunodeficito virusas, imunosupresinė terapija. Pagal sukėlusią priežastį konjunktyvitai yra skirstomi į infekcinius (bakterinius, virusinius, grybelinius) ir neinfekcinius (alerginius). Kiekvienu atveju etiologijai nustatyti reikalinga išsami ligos anamnezė bei paciento apžiūra, kadangi pagrindiniai nusiskundimai būna panašūs, o laboratoriniai tyrimai rutiniškai nėra atlie...

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“…A study in China previously reported conjunctivitis in 0.8% COVID-19 patients (9 of 1099) [ 10 ]. COVID-19 penetrates into the conjunctiva the same way it does the lungs, using angiotensin-converting enzyme subtype 2 receptor on corneal epithelial cells via the assistance of heparan sulfate proteoglycan receptors [ 12 ]. If the condition persists without treatment, major complications such as punctate keratitis with subepithelial infiltrates, bacterial superinfection, conjunctival scarring, and symblepharon, severe dry eye, irregular astigmatism, corneal ulceration with persistent keratoconjunctivitis, corneal scarring, and chronic infection can occur [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Chlamydia trachomatis Mimicking COVID-19 Chronic Follicular Conjunctivitis

Kaur

Teibel

Farhat

et al. 2021

Case Reports in Ophthalmological Medicine

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Purpose. To characterize the clinical presentation and report lab findings of Chlamydia trachomatis follicular conjunctivitis in two patients with a positive history of active COVID-19 infection. Participants. Two patients with follicular conjunctivitis with a recent history of COVID-19 infection. Design. Retrospective, noncomparative, case report. Methods. Demographic data including age, gender, and place of residence were recorded. A full exam with an emphasis on inflammatory characteristics and systematic workup. Sample follicles were surgically excised in selected cases, and molecular and histopathological analyses were performed. Results. Both patients were initially treated for viral conjunctivitis. After symptoms failed to resolve, biopsy results indicated that both patients were positive for chlamydia conjunctivitis and treated accordingly. Conclusions. These cases illustrate the role of biopsy as an investigative tool in chronic conjunctivitis and the importance of having a broad differential when treating patients with acute conjunctivitis.

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Ocular chlamydial infections. Clinicomicrobiological correlation

Cited by 4 publications

References 0 publications

Chlamydial eye infections: Current perspectives

Chlamydial eye infections: Current perspectives

Lėtinis Chlamidinis Konjunktyvitas: Atvejo Pristatymas

Chlamydia trachomatis Mimicking COVID-19 Chronic Follicular Conjunctivitis

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