Ocular artery thrombosis as an initial presentation of a prothrombin G20210A mutation

Parc, C.; Tiberghien, E.; Pierre-Kahn, Vincent

doi:10.1016/j.jfo.2010.03.022

Cited by 5 publications

(2 citation statements)

References 7 publications

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“…Attention has shifted in recent years to the characterization and evaluation of novel risk factors for arterial thrombosis, including lipoprotein metabolism and the coagulation and fibrinolytic systems [22,23,24]. Some anecdotal case reports and rare case series with patient numbers ranging from 9 to 41 have suggested that the presence of thrombophilic defects may be associated with the development of RAO [25,26,27]. Most of these studies did not take into account the presence of cardiovascular risk factors or patient age by the time of the RAO.…”

Section: Discussionmentioning

confidence: 99%

Selective Thrombophilia Screening in Young Patients with Retinal Artery Occlusion

Kuhli-Hattenbach

Hellstern²,

Miesbach

et al. 2016

Ophthalmologica

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Purpose: To investigate the prevalence of various thrombophilic disorders among young patients with retinal artery occlusion (RAO). Procedures: We retrospectively reviewed thrombophilia screening data of young patients ≤60 years of age with RAO and healthy controls matched for gender and age. Results: Thrombophilia screening data of 25 young patients and 62 healthy controls were analyzed. Mean patient age by the time of the RAO was 43.3 ± 10.8 years. Overall, thrombophilic defects were found to be present in 17 patients (68%) compared with 11 of 62 controls (17.7%; p < 0.0001). Multivariate logistic regression analysis confirmed a statistically significant association between the development of RAO and increased levels of lipoprotein(a) (odds ratio: 9.48; p = 0.001) and factor VIII (odds ratio: 6.41; p = 0.024). There was a strong association between the presence of thrombophilic disorders and a personal or family history of thromboembolism (p = 0.01). Conclusions: Our results indicate that screening for thrombophilic disorders among selected young patients with RAO yields positive results in a high percentage of cases.

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Section: Discussionmentioning

confidence: 99%

Selective Thrombophilia Screening in Young Patients with Retinal Artery Occlusion

Kuhli-Hattenbach

Hellstern²,

Miesbach

et al. 2016

Ophthalmologica

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“…(12) found evidence of an increased risk for cerebral ischemia in men under 60. There have been reported cases of ocular and basilar artery thromboses in young patients with the PTHR mutation (13, 14). As ischemic colitis is most frequently caused by an insult to the mesenteric artery, this case of recurrent ischemic colitis in a young patient further supports the link between the PTHR mutation and risk of arterial thrombosis (6, 15).…”

mentioning

confidence: 99%

Recurrent ischemic colitis in a young female with the prothrombin G20210A mutation

Albert

Rudolph

Zitin

et al. 2012

European J of Haematology

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Central Retinal Artery Occlusion

Hayreh¹

2014

Ocular Vascular Occlusive Disorders

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Ocular artery thrombosis as an initial presentation of a prothrombin G20210A mutation

Cited by 5 publications

References 7 publications

Selective Thrombophilia Screening in Young Patients with Retinal Artery Occlusion

Selective Thrombophilia Screening in Young Patients with Retinal Artery Occlusion

Recurrent ischemic colitis in a young female with the prothrombin G20210A mutation

Central Retinal Artery Occlusion

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