Octyl Methoxycinnamate Modulates Gene Expression and Prevents Cyclobutane Pyrimidine Dimer Formation but not Oxidative DNA Damage in UV-Exposed Human Cell Lines

Duale, Nur; Olsen, Ann‐Karin; Christensen, Terje; Butt, Shamas T.; Brunborg, Gunnar

doi:10.1093/toxsci/kfq005

Cited by 44 publications

(39 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Epidemiological studies have identified many etiologic factors, including reactive oxygen species[5], radiation[6],[7], UV light[8] and various carcinogens[9]. These factors can damage DNA including formation of double-strand break (DSB).…”

Section: Introductionmentioning

confidence: 99%

Effect of EME1 exon variant Ile350Thr on risk and early onset of breast cancer in southern Chinese women

Zhao

Liu²,

Zhang

et al. 2013

J Biomed Res

View full text Add to dashboard Cite

Essential meiotic endonuclease 1 homolog 1 (EME1) is a key DNA repair protein that participates in the recognition and repair of DNA double-strand breaks. Deficiency of the EME1 gene can lead to spontaneous genomic instability and thus contribute to tumorgenesis. We hypothesized that the exon variants of EME1 confer genetic susceptibility to breast cancer. In a case-control study of 748 breast cancer patients and 778 normal controls, we analyzed the association between two exon variants of EME1 (i.e.,Ile350Thr: rs12450550T > C and Glu69Asp: rs3760413T > G) and breast cancer risk. We found that compared to the common Ile/Ile genotype, the Thr variant genotypes (Thr/Ile + Thr/Thr) conferred a 1.47-fold increased risk of breast cancer (OR=1.47, 95% CI=1.13-1.92). The variant Ile350Thr was also associated with early onset of breast cancer (r = -0.116, P = 0.002). The mean age of onset was 44.4 years for Thr/Thr genotype carriers and 46.5 years for Thr/Ile genotype carriers, which was significantly lower than that (49.4 years) for Ile/Ile genotype carriers (P = 0.006). Moreover, no significant association was observed between the Glu69Asp variant and breast cancer risk. Our findings suggest that the EME1 variant Ile350Thr contributes to an increased risk and early onset of breast cancer.

show abstract

Section: Introductionmentioning

confidence: 99%

Effect of EME1 exon variant Ile350Thr on risk and early onset of breast cancer in southern Chinese women

Zhao

Liu²,

Zhang

et al. 2013

J Biomed Res

View full text Add to dashboard Cite

show abstract

“…As far as tumor induction and genotoxicity are concerned, evaluation of the prevention against DNA damage appears thus as an interesting parameter in addition to SPF and PPD. Evidence for DNA protection afforded by sunscreens has been gained from studies on several models including mice (10) and cultured cells (11,12) while more relevant data were acquired on human skin either in volunteers or ex vivo (13–19). All data unambiguously show that sunscreens afford protection against DNA damage, usually revealed by the reduced level of pyrimidine dimers measured by immunological approaches.…”

Section: Introductionmentioning

confidence: 99%

Assessment of the Photoprotection Properties of Sunscreens by Chromatographic Measurement of DNA Damage in Skin Explants

Mouret

Bogdanowicz

Haure

et al. 2010

Photochem & Photobiology

View full text Add to dashboard Cite

Evaluation of the photoprotection provided by sunscreens is performed either through the induction of erythema and expressed as the sun protection factor (SPF), or by the UVA-mediated persistent pigment darkening (PPD). None of these two endpoints has a link with skin cancer, the most deleterious consequence of excess exposure to solar UV radiation. We thus set up a complementary approach to evaluate the protection provided by sunscreens to the genome of human skin. This is based on the quantification of the thymine cyclobutane dimer (TT-CPD), the main DNA lesion induced by both UVB and UVA radiations. Irradiations were performed ex vivo on human skin explants and the level of TT-CPD in DNA was determined by HPLC associated with tandem mass spectrometry. The technique was first optimized and validated with three standard sunscreens. The study was then extended to the evaluation of a commercial high SPF sunscreen exhibiting efficient UVA photoprotection. The DNA protecting factor was found to reflect the ratio between UVB and UVA photoprotection, although the absolute values of the genomic protection were, as a general trend, lower than either SPF or PPD. These data show the usefulness of the proposed approach for the evaluation of the genoprotection afforded by sunscreens.

show abstract

“…However, according to Klug et al . , the main cause of skin cancer is the exposure to UV radiation, which occurs when this radiation penetrates the ozone layer with an increased potential to induce skin cancer .…”

Section: Sunlight and Uv Raysmentioning

confidence: 99%

Plant‐based active photoprotectants for sunscreens

Cefali

Ataide

Moriel

et al. 2016

Intern J of Cosmetic Sci

126

View full text Add to dashboard Cite

Excessive exposure to the sun's radiation is the major exogenous mediator of skin damage, which accelerates skin ageing and increases the risk of developing skin cancer. Compounds with photoprotectant activity are extremely useful for decreasing the effect of ultraviolet (UV) radiation on the skin; however, numerous sun filters, especially organic sunscreens, are allergenic. Therefore, the development of formulations containing plant extracts, which may be potentially safer, is extensively being explored. Plant-based cosmetics are commonly used to avoid skin ageing because they contain antioxidant agents that minimize free radical activity, and numerous studies have investigated the skin-protectant effects of related plant species. In addition to their antioxidant properties, plant-based cosmetics protect the skin against solar radiation because they contain polyphenols such as flavonoids and carotenoids. Therefore, this study aims to present a review of plant species commonly used in sunscreens to protect the skin against damage due to sunlight exposure.R esum e L'exposition excessive au rayonnement du soleil est le principal m ediateur exog ene de dommages a la peau, ce qui acc el ere le vieillissement de la peau et augmente le risque de d evelopper un cancer de la peau. Les compos es ayant une activit e photo-protectrice sont extrêmement utiles pour r eduire l'effet du rayonnement ultraviolet (UV) sur la peau; Toutefois, de nombreux filtres solaires, en particulier les filtres solaires organiques, sont allergisantes. Par cons equent, le d eveloppement de formulations contenant des extraits de plantes, qui peuventêtre potentiellement plus sûres, est largement explor ee. Des cosm etiques a base de plantes sont couramment utilis es pour eviter le vieillissement de la peau, car ils contiennent des agents antioxydants qui r eduisent l'activit e des radicaux libres, et de nombreuses etudes ont etudi e les effets protecteurs des esp eces de plantes apparent ees. En plus de leurs propri et es antioxydantes, les cosm etiques a base de plantes prot egent la peau contre le rayonnement solaire, car ils contiennent des polyph enols tels que les flavono€ ıdes et les carot eno€ ıdes. Par cons equent, cette etude vise a pr esenter un examen des esp eces v eg etales couramment utilis ees dans les ecrans solaires pour prot eger la peau contre les dommages dus a l'exposition au soleil.

show abstract

Octyl Methoxycinnamate Modulates Gene Expression and Prevents Cyclobutane Pyrimidine Dimer Formation but not Oxidative DNA Damage in UV-Exposed Human Cell Lines

Cited by 44 publications

References 49 publications

Effect of EME1 exon variant Ile350Thr on risk and early onset of breast cancer in southern Chinese women

Effect of EME1 exon variant Ile350Thr on risk and early onset of breast cancer in southern Chinese women

Assessment of the Photoprotection Properties of Sunscreens by Chromatographic Measurement of DNA Damage in Skin Explants

Plant‐based active photoprotectants for sunscreens

Contact Info

Product

Resources

About