Octyl Gallate Inhibits ATP-induced Intracellular Calcium Increase in PC12 Cells by Inhibiting Multiple Pathways

Guo, Yujie; Hong, Yi Jae; Jang, Hyun‐Jong; Kim, Myung-Jun; Rhie, Duck-Joo; Jo, Yang-Hyeok; Hahn, Sang June; Yoon, Shin Hee

doi:10.4196/kjpp.2010.14.1.21

Cited by 7 publications

(8 citation statements)

References 47 publications

(50 reference statements)

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“…The photons are absorbed by cytochrome c oxidase in respiratory chain that increases electron transport thus increasing MMP and ATP synthesis. However a transient increase in MMP in normal cells could lead to increased electron leakage from the respiratory chain thus producing ROS, and moreover the increased production of ATP could lead to a transient increase in intracellular calcium by the phenomenon known as ATP-induced intracellular calcium increase [48, 49]. The transient increase in NO could also be explained by the recent finding [50] that in hippocampal neurons ATP can induce NO production via activation of ionotropic P2X 7 (a purinoceptor for ATP) and hence up-regulation of neuronal nitric oxide synthase.…”

Section: Discussionmentioning

confidence: 99%

Low‐level laser therapy (810 nm) protects primary cortical neurons against excitotoxicity in vitro

Huang

Nagata

Tedford³

et al. 2013

Journal of Biophotonics

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Excitotoxicity describes a pathogenic process whereby death of neurons releases large amounts of the excitatory neurotransmitter glutamate, which then proceeds to activate a set of glutamatergic receptors on neighboring neurons (glutamate, N-methyl-D-aspartate (NMDA), and kainate), opening ion channels leading to an influx of calcium ions producing mitochondrial dysfunction and cell death. Excitotoxicity contributes to brain damage after stroke, traumatic brain injury, and neurodegenerative diseases, and is also involved in spinal cord injury. We tested whether low level laser (light) therapy (LLLT) at 810-nm could protect primary murine cultured cortical neurons against excitotoxicity in vitro produced by addition of glutamate, NMDA or kainate. Although the prevention of cell death was modest but significant, LLLT (3 J/cm2 delivered at 25 mW/cm2 over 2 min) gave highly significant benefits in increasing ATP, raising mitochondrial membrane potential, reducing intracellular calcium concentrations, reducing oxidative stress and reducing nitric oxide. The action of LLLT in abrogating excitotoxicity may play a role in explaining its beneficial effects in diverse central nervous system pathologies. ((Figure: 5a)) Effect of 810-nm laser on intracellular reactive oxygen species (ROS) in cortical neurons with excitotoxicity

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Section: Discussionmentioning

confidence: 99%

Low‐level laser therapy (810 nm) protects primary cortical neurons against excitotoxicity in vitro

Huang

Nagata

Tedford³

et al. 2013

Journal of Biophotonics

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“…Phenolic compounds inhibited Kv1.3 channels activity in human T lymphocytes (Teisseyre et al. , 2009) and prevented ATP‐induced activation of voltage‐gated Ca 2+ channels in PC12 cells (Guo et al. , 2010).…”

Section: Membrane Transporters and Secondary Metabolite Phytotoxicitymentioning

confidence: 99%

“…The possibility of direct regulation of ion transporter activity by phenolics and other phytotoxins is also supported by the data from animal literature. Phenolic compounds inhibited Kv1.3 channels activity in human T lymphocytes (Teisseyre et al, 2009) and prevented ATPinduced activation of voltage-gated Ca 2+ channels in PC12 cells (Guo et al, 2010). Two pore domain, mechano-sensitive K + TREK channels were stimulated by a range of polyunsaturated fatty acids (Lesage et al, 2000).…”

Section: Ionic Basis Of Tolerance To Phytotoxinsmentioning

confidence: 99%

Physiological and cellular aspects of phytotoxicity tolerance in plants: the role of membrane transporters and implications for crop breeding for waterlogging tolerance

2010

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SummaryWaterlogging affects large areas of agricultural land, resulting in severe economic penalties because of massive losses in crop production. Traditionally, plant breeding for waterlogging tolerance has been based on the field assessment of a range of agronomic and morphological characteristics. This review argues for a need to move towards more physiologically based approaches by targeting specific cellular mechanisms underling key components of waterlogging tolerance in plants. Also, while the main focus of researchers was predominantly on plant anoxia tolerance, less attention was given to plant tolerance to phytotoxins under waterlogged conditions. This paper reviews the production of major elemental and organic phytotoxins in waterlogged soils and describes their adverse effects on plant performance. The critical role of plasma membrane transporters in plant tolerance to secondary metabolite toxicity is highlighted, and ionic mechanisms mediating the this tolerance are discussed. A causal link between the secondary metaboliteinduced disturbances to cell ionic homeostasis and programmed cell death is discussed, and a new ethylene-independent pathway for aerenchyma formation is put forward. It is concluded that plant breeding for waterlogging tolerance may significantly benefit from targeting mechanisms of tolerance to phytotoxins.

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“…In addition, it may also be involved in various pathophysiologic changes [8,23]. Muscarinic and purinergic receptors are well known to raise [Ca 2＋ ]i by releasing Ca 2＋ from intracellular stores [24]. We, previously, demonstrated that the M3 and M5 muscarinic subtypes were expressed and mobilized Ca 2＋ via PLC-IP3-dependent pathway in retinoblastoma cells [25].…”

Section: Discussionmentioning

confidence: 99%

Functional Expression of P2Y Receptors in WERI-Rb1 Retinoblastoma Cells

Kim

Park

Sohn

et al. 2011

Korean J Physiol Pharmacol

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Octyl Gallate Inhibits ATP-induced Intracellular Calcium Increase in PC12 Cells by Inhibiting Multiple Pathways

Cited by 7 publications

References 47 publications

Low‐level laser therapy (810 nm) protects primary cortical neurons against excitotoxicity in vitro

Low‐level laser therapy (810 nm) protects primary cortical neurons against excitotoxicity in vitro

Physiological and cellular aspects of phytotoxicity tolerance in plants: the role of membrane transporters and implications for crop breeding for waterlogging tolerance

Functional Expression of P2Y Receptors in WERI-Rb1 Retinoblastoma Cells

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