Functional Expression of P2Y Receptors in WERI-Rb1 Retinoblastoma Cells

Kim, Na Hyun; Park, Kyu Sang; Sohn, Joon Hyung; Yeh, Byung Il; Ko, Chang Mann; Kong, In Deok

doi:10.4196/kjpp.2011.15.1.61

Cited by 5 publications

(4 citation statements)

References 38 publications

(54 reference statements)

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“…However, γ-irradiation increased the incidence of multiple Ca 2+ peaks in A549 cells which suggests that Ca 2+ -induced Ca 2+ release mechanism was activated by γ-irradiation ( Table 5 ). To clarify the involvement of this Ca 2+ -induced Ca 2+ release mechanism in radiation-induced Ca 2+ deregulation, further study with immunochemical and molecular biological methods will be needed [ 36 ]. However, the resting values of [Ca 2+ ] i were not increased by multiple Ca 2+ transients ( Table 4 ).…”

Section: Discussionmentioning

confidence: 99%

Distinct Cellular Calcium Metabolism in Radiation-sensitive RKO Human Colorectal Cancer Cells

Kim

Park

et al. 2014

Korean J Physiol Pharmacol

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Radiation therapy for variety of human solid tumors utilizes mechanism of cell death after DNA damage caused by radiation. In response to DNA damage, cytochrome c was released from mitochondria by activation of pro-apoptotic Bcl-2 family proteins, and then elicits massive Ca2+ release from the ER that lead to cell death. It was also suggested that irradiation may cause the deregulation of Ca2+ homeostasis and trigger programmed cell death and regulate death specific enzymes. Thus, in this study, we investigated how cellular Ca2+ metabolism in RKO cells, in comparison to radiation-resistant A549 cells, was altered by gamma (γ)-irradiation. In irradiated RKO cells, Ca2+ influx via activation of NCX reverse mode was enhanced and a decline of [Ca2+]i via forward mode was accelerated. The amount of Ca2+ released from the ER in RKO cells by the activation of IP3 receptor was also enhanced by irradiation. An increase in [Ca2+]i via SOCI was enhanced in irradiated RKO cells, while that in A549 cells was depressed. These results suggest that γ-irradiation elicits enhancement of cellular Ca2+ metabolism in radiation-sensitive RKO cells yielding programmed cell death.

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Section: Discussionmentioning

confidence: 99%

Distinct Cellular Calcium Metabolism in Radiation-sensitive RKO Human Colorectal Cancer Cells

Kim

Park

et al. 2014

Korean J Physiol Pharmacol

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“…For instance, P2Y receptors on retinoblastoma cells are metabolic G-protein-coupled receptors involved in cell function. The activation of these receptors can stimulate RPE fluid pump function, leading to a temporary enhancement in fluid uptake [ 55 , 56 ]. This increased uptake may also prove effective for the incorporation of drug nanoparticles.…”

Section: Barriers To Drug Administration For Ocular Diseasesmentioning

confidence: 99%

Advancements in Nanogels for Enhanced Ocular Drug Delivery: Cutting-Edge Strategies to Overcome Eye Barriers

Lee,

Noh

2023

Gels

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Nanomedicine in gel or particle formation holds considerable potential for enhancing passive and active targeting within ocular drug delivery systems. The complex barriers of the eye, exemplified by the intricate network of closely connected tissue structures, pose significant challenges for drug administration. Leveraging the capability of engineered nanomedicine offers a promising approach to enhance drug penetration, particularly through active targeting agents such as protein peptides and aptamers, which facilitate targeted release and heightened bioavailability. Simultaneously, DNA carriers have emerged as a cutting-edge class of active-targeting structures, connecting active targeting agents and illustrating their potential in ocular drug delivery applications. This review aims to consolidate recent findings regarding the optimization of various nanoparticles, i.e., hydrogel-based systems, incorporating both passive and active targeting agents for ocular drug delivery, thereby identifying novel mechanisms and strategies. Furthermore, the review delves into the potential application of DNA nanostructures, exploring their role in the development of targeted drug delivery approaches within the field of ocular therapy.

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“…When the phospholipase C signal transduction pathway is activated, the PLC-β is also activated through the G protein protein-coupled effects. Under the catalysis of PLC, phosphatidylinositol biphosphate (PIP2) decomposes into inositol triphosphate (IP3) and diacylglycerol (DG), which afects two branches of this pathway respectively (Kim NH et al, 2011). The extracellular signals that stimulate the metabolism of PIP2 include neurotransmitter (oxy-choline-type acetylcholine, α1-adrenaline, 5-HT and H1 histamine), some polypeptide hormones (V1 vasopressin, angiotonin II, substance P and thyrotrophin releasing factor), and growth factor (PDGF and T-cell mitogen) (Lu YM et al, 1993).…”

Section: Phospholipase C Signal Transduction Pathway (Plc)mentioning

confidence: 99%

“…When the phospholipase C signal transduction pathway is activated, the PLC‐β is also activated through the G protein protein‐coupled effects. Under the catalysis of PLC, phosphatidylinositol biphosphate (PIP2) decomposes into inositol triphosphate (IP3) and diacylglycerol (DG), which affects two branches of this pathway respectively (Kim NH et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Advance of signal transduction pathways in normal cell

Zhang

Zhu

Liu

et al. 2016

Ibrain

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Signal transduction pathways are very important for the survival of organisms. Any disturbance of these pathways could induce diseases. For better understanding these diseases to get more benefits for patients, it is necessary to fully understand the signal transduction pathway in a normal cell. Therefore, we summarized these related pieces of literature and introduced the main two kinds of signal transduction pathways.

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Functional Expression of P2Y Receptors in WERI-Rb1 Retinoblastoma Cells

Cited by 5 publications

References 38 publications

Distinct Cellular Calcium Metabolism in Radiation-sensitive RKO Human Colorectal Cancer Cells

Distinct Cellular Calcium Metabolism in Radiation-sensitive RKO Human Colorectal Cancer Cells

Advancements in Nanogels for Enhanced Ocular Drug Delivery: Cutting-Edge Strategies to Overcome Eye Barriers

Advance of signal transduction pathways in normal cell

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