Octopamine in the locust brain: Cellular distribution and functional significance in an arousal mechanism

Stern, Michael

doi:10.1002/(sici)1097-0029(19990501)45:3<135::aid-jemt1>3.0.co;2-g

Cited by 33 publications

(28 citation statements)

References 34 publications

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“…Although there are no reports on the role of other amines in the Drosophila startle response per se, OA has been suggested to increase arousal and mediate the fight-or-flight response in other insects (Adamo et al 1995;Bacon et al 1995;Stern 1999;Rind et al 2008). In negative geotaxis assays, the lower percentage of dVMAT mutants that reach the top of a vial in response to mechanical stimulus may be due in part to a diminished startle response (Simon et al 2009).…”

Section: Dopamine and Octopamine Play Complementary Or Redundant Rolementioning

confidence: 91%

“…Expression of UAS-DVMAT using Tdc2-Gal4 rescued some of these deficits, including peak velocity and distance traveled in response to startle, clearly demonstrating an important role for OA and perhaps TA in some aspects of adult startle response and locomotion. These data are consistent with the proposed role for OA in both arousal and the fight-or-flight response in other insects (Adamo et al 1995;Bacon et al 1995;Stern 1999;Rind et al 2008).…”

Section: Complementary Aminergic Circuitsmentioning

confidence: 99%

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Dispensable, Redundant, Complementary, and Cooperative Roles of Dopamine, Octopamine, and Serotonin inDrosophila melanogaster

Chen

Lebestky

et al. 2013

Genetics

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To investigate the regulation of Drosophila melanogaster behavior by biogenic amines, we have exploited the broad requirement of the vesicular monoamine transporter (VMAT) for the vesicular storage and exocytotic release of all monoamine neurotransmitters. We used the Drosophila VMAT (dVMAT) null mutant to globally ablate exocytotic amine release and then restored DVMAT activity in either individual or multiple aminergic systems, using transgenic rescue techniques. We find that larval survival, larval locomotion, and female fertility rely predominantly on octopaminergic circuits with little apparent input from the vesicular release of serotonin or dopamine. In contrast, male courtship and fertility can be rescued by expressing DVMAT in octopaminergic or dopaminergic neurons, suggesting potentially redundant circuits. Rescue of major aspects of adult locomotion and startle behavior required octopamine, but a complementary role was observed for serotonin. Interestingly, adult circadian behavior could not be rescued by expression of DVMAT in a single subtype of aminergic neurons, but required at least two systems, suggesting the possibility of unexpected cooperative interactions. Further experiments using this model will help determine how multiple aminergic systems may contribute to the regulation of other behaviors. Our data also highlight potential differences between behaviors regulated by standard exocytotic release and those regulated by other mechanisms. BOTH invertebrate and mammalian behaviors undergo extensive regulation by monoamine neurotransmitters (reviewed in Joshua et al.

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Section: Dopamine and Octopamine Play Complementary Or Redundant Rolementioning

confidence: 91%

Section: Complementary Aminergic Circuitsmentioning

confidence: 99%

Dispensable, Redundant, Complementary, and Cooperative Roles of Dopamine, Octopamine, and Serotonin inDrosophila melanogaster

Chen

Lebestky

et al. 2013

Genetics

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“…This cluster consists of ipsilaterally and bilaterally projecting neurons (OAAL2i and OA-AL2b, respectively). Importantly, they share striking structural similarity to the neurons PM4 and PM5 in the locust (Stern et al, 1995;Stern, 1999). They are shown to be involved in dishabituating the response of the descending contralateral movement detector.…”

Section: Large-scale Identification Of Individual Octopaminergic Neuronsmentioning

confidence: 99%

“…Another example is the locust PM4 neurons, which innervate the optic lobe. They contribute to the dishabituation of the visual interneuron DCMD presumably by releasing OA (Stern, 1999). To systematically understand the function of each octopaminergic neuron, a comprehensive anatomical description is essential.…”

mentioning

confidence: 99%

A map of octopaminergic neurons in the Drosophila brain

Busch

Selcho²,

Ito³

et al. 2009

J of Comparative Neurology

233

329

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“…Indeed, changes in the processing of visual information are indicated for the neuronal pathway mediating head movements of flies, where the motor activity state has been shown to affect optomotor head responses (Rosner et al, 2009). In locusts, changes in the responses of visual neurones associated with different behavioural states (Rowell, 1971;Rind et al, 2008) are thought to be elicited by octopamine, a biogenic amine (Bacon et al, 1995;Stern, 1999). Octopamine was also concluded to modulate the response properties of motion-sensitive neurones in bees (Kloppenburg and Erber, 1995) and LPTCs in flies (Longden and Krapp, 2009) † .…”

Section: Introductionmentioning

confidence: 99%

Behavioural state affects motion-sensitive neurones in the fly visual system

Rosner

Egelhaaf

Warzecha

2010

Journal of Experimental Biology

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SUMMARYThe strength of stimulus-induced responses at the neuronal and the behavioural level often depends on the internal state of an animal. Within pathways processing sensory information and eventually controlling behavioural responses, such gain changes can originate at several sites. Using motion-sensitive lobula plate tangential cells (LPTCs) of blowflies, we address whether and in which way information processing changes for two different states of motor activity. We distinguish between the two states on the basis of haltere movements. Halteres are the evolutionarily transformed hindwings of flies. They oscillate when the animals walk or fly. LPTCs mediate, amongst other behaviours, head optomotor responses. These are either of large or small amplitude depending on the state of motor activity. Here we find that LPTC responses also depend on the motor activity of flies. In particular, LPTC responses are enhanced when halteres oscillate. Nevertheless, the response changes of LPTCs do not account for the corresponding large gain changes of head movements. Moreover, haltere activity itself does not change the activity of LPTCs. Instead, we propose that a central signal associated with motor activity changes the gain of head optomotor responses and the response properties of LPTCs.

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Octopamine in the locust brain: Cellular distribution and functional significance in an arousal mechanism

Cited by 33 publications

References 34 publications

Dispensable, Redundant, Complementary, and Cooperative Roles of Dopamine, Octopamine, and Serotonin inDrosophila melanogaster

Dispensable, Redundant, Complementary, and Cooperative Roles of Dopamine, Octopamine, and Serotonin inDrosophila melanogaster

A map of octopaminergic neurons in the Drosophila brain

Behavioural state affects motion-sensitive neurones in the fly visual system

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