Octahedral Pt-MOF with Au deposition for plasmonic effect and Schottky junction enhanced hydrogenothermal therapy of rheumatoid arthritis

A Smart Nanoreactor Based on an O2-Economized Dual Energy Inhibition Strategy Armed with Dual Multi-stimuli-Responsive “Doorkeepers” for Enhanced CDT/PTT of Rheumatoid Arthritis

“…In contrast, the fluorescence intensity of free Cy5 and Cy5-labeled HAGC NPs showed a downward trend over the course of time, and the fluorescence intensity of free Cy5 was significantly lower than that of the group Cy5-labeled V-HAGC NPs at each time point, while the fluorescence intensity of the free Cy5 group was the smallest except for the normal saline group (Figure S19, Supporting Information). Such enhancement of the fluorescence signal intensity of Cy5-labeled V-HAGC NPs may be explained by two dominant mechanisms: (1) extravasation through leaky vasculature and the subsequent inflammatory cell mediated sequestration (ELVIS) effect; 63 (2) high cellular uptake of V-HAGC NPs into FLS cells mediated by VIP receptors abundant on the FLS cells via active preferential targeting. In addition, although a certain intensity of the fluorescence signal was observed in the liver, lung, and kidney of mice, the strongest fluorescence was still observed in the paw area, further confirming the bioconcentration of the targeted region and the biosafety of the nontargeted region (Figure S20, Supporting Information).…”

Growth of Cu2O Nanoparticles on Two-Dimensional Zr–Ferrocene–Metal–Organic Framework Nanosheets for Photothermally Enhanced Chemodynamic Antibacterial Therapy

“…Two-dimensional (2D) MOF nanomaterials constructed from metal-containing units and organic linkers have recently emerged and attracted extensive research attention especially in the biomedical field because they possess precise crystal structure, abundant metal active sites, designable organic ligands, and tunable nanosize. − In order to further enhance their performance or achieve multifunctionalities, 2D MOF nanosheets have been used as promising templates for the growth of other nanomaterials on their surfaces to construct 2D composites. − For example, some noble metals (Au and Ag) or metal oxide (Fe 2 O 3 ) nanoparticles have been deposited on the surface of 2D porphyrin-based MOF nanosheets as effective photosensitizers for combined cancer/antibacterial therapy. − Promisingly, 2D ferrocene-based MOFs (Fc-MOFs) not only possess porous frameworks but also exhibit high stability and extraordinary NIR optical activities, and thus have been successively developed for photothermal cancer therapy. − Although some 2D Fc-MOF-based composites (such as Au, Pt, and polyoxometalates) have been prepared, they mainly focused on the application in catalysis. − Therefore, the growth of other nanomaterials on 2D Fc-MOF nanosheets to construct 2D composites for antibacterial therapy still remains unexplored.…”

A Mini-Review of Diagnostic and Therapeutic Nano-Tools for Pancreatitis

“…26 A growing number of studies exploit the ELVIS effect to enable passive targeting of nanoparticles to sites of inflammation and reduced systemic toxicity. [27][28][29][30] In pancreatitis, the nanoparticles with ELVIS effect has shown promise. For example, Yang et al developed a PLGA nanoparticles (CQ/pDNA/PLGA NPs), which co-loaded chloroquine diphosphate (CQ) and pDNA, to achieve targeted delivery to tumors and pancreatitis.…”