OCT En Face Analysis of the Posterior Vitreous Reveals Topographic Relationships among Premacular Bursa, Prevascular Fissures, and Cisterns

Leong, Belinda C.S.; Fragiotta, Serena; Kaden, Talia R; Freund, K. Bailey; Zweifel, Sandrine; Engelbert, Michael

doi:10.1016/j.oret.2019.09.002

Cited by 15 publications

(16 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The BP dimensions that we measured in our 45 healthy individuals (Fig. 1A) are similar to those from other studies (Itakura et al 2015;Park et al 2018;Leong et al 2020). New data reported in our study showed that the diameters and consequently the area of the PB are significantly larger in eyes affected by AU compared to age-and gendermatched controls (p < 0.01).…”

Section: Discussionsupporting

confidence: 90%

“…1B). Leong et al (Leong et al 2020) observed a connection between the PB and Cloquet's canal in 65.4% of the eyes in their study, while Itakura et al (Itakura et al 2015) found a higher incidence of 93.1% of adults.…”

Section: Discussionmentioning

confidence: 74%

“…The in vivo assessment of these structures has recently become feasible with the advent of OCT (Hwang et al 2020), but even then, this analysis has been limited by resolution and scan volume. With the advent of SS-OCT technology characterized by a faster acquisition procedure and unprecedented resolution, volume and sampling density, the vitreous analysis is nowadays easily achieved (Park et al 2018;She et al 2019;Leong et al 2020).…”

Section: Discussionmentioning

confidence: 99%

“…There have been speculations in the past that inflammation of the anterior chamber after cataract surgery (Schaal et al 2014;Matas et al 2019) which diffuse throughout the vitreous and provoke macular oedema. In anterior uveitis, the presence of connected, empty spaces in the vitreous could facilitate the penetration of inflammatory cytokines from the anterior to the posterior chamber (Leong et al 2020) and allow them to reach the premacular area more easily, causing CME. In our study, no connecting channel was seen in 27/50 eyes of healthy subjects (54%) and in 12/90 eyes with AU (13.3%), while all the eyes with AU complicated by CME showed the presence of such a communication.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

An en face swept source optical coherence tomography study of the vitreous in eyes with anterior uveitis

Pichi

Neri

Hay

et al. 2021

Acta Ophthalmologica

View full text Add to dashboard Cite

Purpose To analyse vitreous anatomy patients with anterior uveitis (AU) using swept source optical coherence tomography (SS‐OCT). Methods Patients with newly diagnosed AU and healthy participants were scanned using 16‐mm SS‐OCT B‐scans and 12 × 12 mm cube centred at the fovea. Linear SS‐OCT scans were evaluated to identify the premacular bursa (PB) above the macula and the Cloquet’s canal above the optic disc. A dynamic evaluation of the 12 × 12 mm cube enabled en face measurement of the vertical and horizontal diameters of the PB and the presence/absence of communication between the PB and Cloquet’s canal. Results One hundred and thirty‐five subjects were included in the study. Forty‐five patients were healthy (mean age 33.47 years). En face measurements of the horizontal and vertical PB mean diameters were 5.2 mm and 4.7 mm. In 90 subjects with AU (mean age 30.10 years), the mean horizontal and vertical diameter of the PB were significantly larger (p < 0.01). Thirty‐seven eyes with AU presented with cystoid macular oedema (CME). The mean diameters of the PB in this subgroup were significantly larger (p < 0.01). In 75% of the entire cohort (51% of eyes in the control group, 87% of eyes with AU and 100% of eyes with AU and CME), a channel connecting the PB and Cloquet’s canal could be identified. Conclusions SS‐OCT identification of a connecting channel between the PB and the Cloquet’s canal suggests that inflammatory cytokines may drain from the anterior chamber through this system of channels, thus increasing the risk of CME.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

An en face swept source optical coherence tomography study of the vitreous in eyes with anterior uveitis

Pichi

Neri

Hay

et al. 2021

Acta Ophthalmologica

View full text Add to dashboard Cite

show abstract

“…This is suggested by their smaller size compared to age-related lacunae and their location just above where the worm was identified. 13 Fig. 5 B shows the corresponding b-scan, where these lacunae can be seen as dark voids in the vitreous.…”

Section: Discussionmentioning

confidence: 99%

Enface vitreous OCT ‘worm holes’: A novel finding in a patient with diffuse unilateral subacute neuroretinitis (DUSN)

Sodhi

Golding²,

Mandelcorn

et al. 2021

American Journal of Ophthalmology Case Reports

View full text Add to dashboard Cite

Purpose To describe a case of diffuse unilateral subacute neuroretinitis (DUSN), a rare condition that causes progressive vision loss following infection by a nematode using enface vitreous imaging. Observations We present the clinical findings of a 37-year-old female, clinically diagnosed with DUSN after a non-invasive multimodal imaging approach that included MultiColor scanning laser imaging and enface vitreous OCT, which revealed the nematode body and lacunae created by worm migration, respectively. Conclusion and importance To our knowledge, this is the first reported case of lacunae visualized using enface vitreous optical coherence tomography (OCT), potentially marking the migration path of the nematode.

show abstract

Advances in swept-source optical coherence tomography and optical coherence tomography angiography

Zheng

Deng

Zhang

et al. 2023

Advances in Ophthalmology Practice and Research

View full text Add to dashboard Cite

OCT En Face Analysis of the Posterior Vitreous Reveals Topographic Relationships among Premacular Bursa, Prevascular Fissures, and Cisterns

Cited by 15 publications

References 19 publications

An en face swept source optical coherence tomography study of the vitreous in eyes with anterior uveitis

An en face swept source optical coherence tomography study of the vitreous in eyes with anterior uveitis

Enface vitreous OCT ‘worm holes’: A novel finding in a patient with diffuse unilateral subacute neuroretinitis (DUSN)

Advances in swept-source optical coherence tomography and optical coherence tomography angiography

Contact Info

Product

Resources

About