Advances in swept-source optical coherence tomography and optical coherence tomography angiography

Zheng, Fang; Deng, Xiaofeng; Zhang, Qi; He, Jingliang; Ye, Panpan; Liu, Shan; Li, Peng; Zhou, Jing; Fang, Xiaoyun

doi:10.1016/j.aopr.2022.10.005

Cited by 18 publications

(13 citation statements)

References 170 publications

(177 reference statements)

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“…SS-OCT has shown tremendous progress in signal quality, imaging depth, imaging speed, sensitivity, and field of view (FOV). 10 Although intraoperative SS-OCT would benefit from the same advantages, it has not yet been implemented in commercial devices. Nevertheless, intraoperative SS-OCT prototypes have previously been used in both porcine eyes and human surgeries but lack flexibility due to fixed sampling rates, low imaging speed, and small imaging depth.…”

Section: Introductionmentioning

confidence: 99%

Visualization of Cataract Surgery Steps With 4D Microscope-Integrated Swept-Source Optical Coherence Tomography in Ex Vivo Porcine Eyes

Britten,

Matten,

Nienhaus

et al. 2024

Trans. Vis. Sci. Tech.

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Purpose To investigate the visualization capabilities of high-speed swept-source optical coherence tomography (SS-OCT) in cataract surgery. Methods Cataract surgery was simulated in wet labs with ex vivo porcine eyes. Each phase of the surgery was visualized with a novel surgical microscope-integrated SS-OCT with a variable imaging speed of over 1 million A-scans per second. It was designed to provide four-dimensional (4D) live-volumetric videos, live B-scans, and volume capture scans. Results Four-dimensional videos, B-scans, and volume capture scans of corneal incision, ophthalmic viscosurgical device injection, capsulorrhexis, phacoemulsification, intraocular lens (IOL) injection, and position of unfolded IOL in the capsular bag were recorded. The flexibility of the SS-OCT system allowed us to tailor the scanning parameters to meet the specific demands of dynamic surgical steps and static pauses. The entire length of the eye was recorded in a single scan, and unfolding of the IOL was visualized dynamically. Conclusions The presented novel visualization method for fast ophthalmic surgical microscope-integrated intraoperative OCT imaging in cataract surgery allowed the visualization of all major steps of the procedure by achieving large imaging depths covering the entire eye and high acquisition speeds enabling live volumetric 4D-OCT imaging. This promising technology may become an integral part of routine and advanced robotic-assisted cataract surgery in the future. Translational Relevance We demonstrate the visualization capabilities of a cutting edge swept-source OCT system integrated into an ophthalmic surgical microscope during cataract surgery.

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Section: Introductionmentioning

confidence: 99%

Visualization of Cataract Surgery Steps With 4D Microscope-Integrated Swept-Source Optical Coherence Tomography in Ex Vivo Porcine Eyes

Britten,

Matten,

Nienhaus

et al. 2024

Trans. Vis. Sci. Tech.

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“…It is also the second most common major optic neuropathy after glaucoma, resulting from acute ischemia in the optic nerve (2). Optical coherence tomographyangiography (OCTA) is a new and non-invasive method of vascular mapping that can provide detailed information about the retinal and choroidal vasculature (3,4).…”

Section: Introductionmentioning

confidence: 99%

Detecting changes in the blood flow of the optic disk in patients with nonarteritic anterior ischemic optic neuropathy via optical coherence tomography–angiography

Xiao

Sun

2023

Front. Neurol.

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PurposeThis study aimed to evaluate the changes in the blood flow of the optic disk in patients with nonarteritic anterior ischemic optic neuropathy (NAION) using optical coherence tomography–angiography (OCTA) and to investigate the relationship among the changes in the blood flow of the optic disk, visual field defect, peripapillary retinal nerve fiber layer (RNFL), and macular ganglion cell complex (mGCC).MethodsThis was a prospective observational case series study. A total of 89 patients (89 eyes) with NAION were included in this study. All patients underwent best corrected visual acuity (BCVA), slit-lamp and direct ophthalmoscopic examinations, color fundus photography, visual field test, and blood flow indicators of the radial peripapillary capillaries (RPC) including whole en face image vessel density (VD), peripapillary VD by OCTA, the peripapillary RNFL, and mGCC by spectral-domain optic coherence tomography (OCT). The changes of blood flow in the optic disk at ≤3, 4–8, 9–12, 13–24, and >24 weeks of the natural course of NAION were measured, and the relationship among the changes in the blood flow of the optic disk, visual field defect, peripapillary RNFL, and mGCC was also analyzed.ResultsThe mean age of 89 patients with NAION was 56.42 ± 6.81 years (ranging from 39 to 79). The initial RPC whole en face image VD was significantly reduced after acute NAION (≤3 weeks) (F = 45.598, P < 0.001) and stabilized from the eighth week onward. Over the course of NAION, the superonasal RPC, superior mGCC, and superotemporal RNFL decreased mostly with time (F = 95.658, 109.787, 263.872, respectively; P < 0.001). Maximal correlations were found between superior mGCC and temporosuperior RPC in the NAION phase (R = 0.683, P < 0.01) and between superonasal RPC and superonasal RNFL (R = 0.740, P < 0.01). The mean defect was correlated with temporosuperior RPC (R = −0.281, P < 0.01) and superior mGCC (R = −0.160, P = 0.012).ConclusionOver the course of NAION, OCTA shows a tendency toward change in the retinal capillary plexus of the optic disk. OCTA is proved to be a practical and useful tool for observing papillary perfusion in NAION.

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“…Retinal astrocytic hamartoma (RAH) is a benign glial tumor that may be present in patients with tuberous sclerosis (TS), 1 a genetic phakomatosis caused by the mutation of the tumor suppressor genes TSC1 or TSC2, affecting ~1 in 6000 people. [2][3][4] Although TS is typically identified by the Vogt triad (facial angiofibroma, mental retardation, and intractable epilepsy), less than 40% of affected patients exhibit all three features, necessitating a careful ophthalmic examination. 5 Ocular involvement in TS can manifest in several forms, such as hypopigmented iris spots, RAHs, and retinal pigment epithelial depigmentation spots.…”

Section: Introductionmentioning

confidence: 99%

“…These attributes provide both detailed qualitative and quantitative information about the retinal structure and vasculature, proving to be fundamental for the diagnosis and monitoring of several diseases. 4 In previous studies, the imaging features of RAH were described using time-domain OCT; however, the low resolution of this technique limited definitive descriptions of certain features. 5 To overcome this limitation, our study used higher resolution OCT-SS, which enabled more detailed visualization of each tumor.…”

Section: Introductionmentioning

confidence: 99%

“…The high speed and the long wavelength (∼1050 nm) of OCT with swept‐source technology (OCT‐SS) offer significantly improved spatial resolution, a larger field of view, enhanced tissue penetration, and superior sensitivity roll‐off performance. These attributes provide both detailed qualitative and quantitative information about the retinal structure and vasculature, proving to be fundamental for the diagnosis and monitoring of several diseases 4 …”

Section: Introductionmentioning

confidence: 99%

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Retinal hamartomas at different stages in a patient with tuberous sclerosis: A OCT‐SS description

Dias,

Linhares,

Hokazono

2023

Clinical Case Reports

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Key Clinical MessageRetinal astrocytic hamartoma (RAH) is a benign glial tumor that may be present in patients with tuberous sclerosis (TS), contributing to the diagnosis of this syndrome. While hamartomas identified through indirect ophthalmoscopy are often large enough to affect vessels and optic disc anatomy, RAH not detected in previous fundoscopies may become apparent in optical coherence tomography (OCT). The purpose of this report was to describe and characterize RAH with OCT with swept‐source technology (OCT‐SS), aiming to establish a more comprehensive classification for these hamartomas due to their diverse presentations. Fundus examination of a 11‐year‐old girl revealed retinal tumors in both eyes. OCT‐SS confirmed the diagnosis of TS, revealing dome‐shaped hyperreflective masses at different stages of evolution. Lesion 1: maximum thickness (MT) of 336 μm and ganglion cell layer disorganization. Lesion 2: MT of 438 μm and preserved outer plexiform layer. Lesion 3: posterior shadow, MT of 1478 μm and complete rupture of retinal anatomy. Lesion 4: MT of 342 μm and preserved retinal anatomy. OCT is a noninvasive method which assists the diagnosis of subclinical lesions and clinical characterization of TS patients.

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Advances in swept-source optical coherence tomography and optical coherence tomography angiography

Cited by 18 publications

References 170 publications

Visualization of Cataract Surgery Steps With 4D Microscope-Integrated Swept-Source Optical Coherence Tomography in Ex Vivo Porcine Eyes

Visualization of Cataract Surgery Steps With 4D Microscope-Integrated Swept-Source Optical Coherence Tomography in Ex Vivo Porcine Eyes

Detecting changes in the blood flow of the optic disk in patients with nonarteritic anterior ischemic optic neuropathy via optical coherence tomography–angiography

Retinal hamartomas at different stages in a patient with tuberous sclerosis: A OCT‐SS description

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